Drug-loaded PLCL/PEO-SA bilayer nanofibrous membrane for controlled release.

The bilayer nanofibrous membrane fabricated electrospinning technique can be considered as an ideal structure for the treatment of chronic skin diseases and exudative wound dressings. Wound exudate would affect healing and increases the likelihood of infection at the same time. Therefore, it is essential to produce a kind of wound dressing with relatively high hygroscopicity which could absorb wound exudate and provide a relatively dry healing environment.

BSA loaded bead-on-string nanofiber scaffold with core-shell structure applied in tissue engineering.

Beaded nanofiber is a promising fibrous structure could act as drug delivery system with sustained drug release for regulating cell behaviors used in tissue engineering. Poly (L-lactic acid-co-ε-caprolactone) (PLCL) beaded nanofiber with core-shell structure (130 ± 30 nm) was fabricated and bovine serum albumin (BSA) was encapsulated into the inner layer. The surface morphology and characteristic were evaluated by scanning electron microscopy (SEM), inverted fluorescence microscopy and water contact angle test.

Preparation and characterization of wormwood-oil-contained microcapsules.

In recent years, wormwood has been successfully applied in various fields, such as flavouring agent, plant dye, insect repellent and medical product. Wormwood oil encapsulated microcapsules with continuous release behaviours would be further applied in the health care textiles. Here, wormwood oil encapsulated microcapsules with different core-wall materials ratios (gelatine: gum arabic: wormwood oil = 1:1:1, 1:1:2, 1:1:3, 1:1:4) were fabricated.

Solid drug particles encapsulated bead-on-string nanofibers: the control of bead number and its corresponding release profile.

Bead-on-string nanofibers are explored as potential carriers of micro-level solid drug particles in recent years in drug release and tissue engineering. The special alternating distribution of nanoscale fiber and micro beads satisfied the fully encapsulation of particle drugs and the corresponding sustained release. Antibiotic drug tetracycline hydrochloride (TCH) was used as solid model drug particles.

Fabrication, mechanical property and in vitro evaluation of poly (L-lactic acid-co-ε-caprolactone) core-shell nanofiber scaffold for tissue engineering.

Coaxial electrospinning, in which Poly (L-lactic acid-co-ε-caprolactone) (PLC) with different Lactic acid (LA) to caprolactone (CL) ratio (75:25 and 50:50) were employed to electrospin core-shell nanofibers which could mimic the native extracellular matrix for tissue engineering applications. Core-shell nanofibrous scaffolds of PLC (50:50)/BSA (426 ± 157 nm) and PLC (75:25)/BSA (427 ± 197 nm) were fabricated and model drug bovine serum albumin (BSA) was entrapped in the core layer. The morphology, core-shell structure and sustained release behaviors were evaluated by Scanning electron microscopy (SEM), transmission electron microscopy (TEM), inverted fluorescence microscopy, water contact angle test and in vitro release test, respectively.

[Correlation of IgG Subclass with Blood Cell Parameters in Patients with Autoimmune Hemolytic anemia].

Objective: To investigate the correlation of IgG subclasses with blood cell parameters in the patients with autoimmune hemolytic anemia (AIHA).

Methods: Thirty-four patients with AIHA (except C3d types) of immune complex type (IgG+C3d) and single IgG type, including 26 cases of primary AIHA and 8 cases of secondary AIHA from December 2010 to August 2016 in our hospital were selected and enrolled in AIHA group; 30 healthy persons were selected and enrolled in healthy control group. The levels of IgG subclasses in blood plasma were detected by double antibody sandwich ELISA in healthy persons and AIHA patients, at the same time.

The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs.

Bead-on-string nanofibers, with appropriate control of the beads diameter, are potential fibrous structures for efficient encapsulation of particle drugs in micron scales and could achieve controlled drug release for tissue engineering applications. In this study, the beads diameter of electrospun bead-on-string nanofibers was controlled by adjusting the concentration of spinning polymer, poly (lactic-co-glycolic acid) (PLGA), and the solvent ratio of chloroform to acetone. The images of the scanning electron microscopy (SEM) suggested that bead-on-string nanofibers could be successfully obtained only with a certain range of PLGA solution concentration.