polysaccharides alleviate hyperglycemia by regulating gut microbiota and its mmetabolites in high-fat diet/streptozocin-induced diabetic mice.

Introduction: The polysaccharides found in () have received increasing academic attention owing to their wide variety of therapeutic activities.

Methods: This study evaluated the hypoglycemic, antioxidant, and anti-inflammatory effects of polysaccharides from (CH-P). In addition, 16s rDNA sequencing and untargeted metabolomics analysis by liquid chromatography-mass spectrometry (LC-MS) were used to estimate the changes and regulatory relationships between gut microbiota and its metabolites.