Characteristics concerning the evolution of dissolved organic matter and dynamics of bacterial community during continuous thermophilic composting of oxytetracycline fermentation residue.

Continuous thermophilic composting (CTC) is a potential technique to recycle oxytetracycline fermentation residue (OFR) with the extremely high level of antibiotics but is still not explored. To investigate the efficiency of CTC on treating OFR, the differences between this technique and conventional composting in the evolution of dissolved organic matter and dynamics of bacterial community were compared. The higher degradation efficiency of oxytetracycline (OTC) was obtained in CTC than conventional composting.

Exploring the Role of Chemokine-Related Gene Deregulation and Immune Infiltration in Ischemic Stroke: Insights into CXCL16 and SEMA3E as Potential Biomarkers.

Ischemic stroke is a leading cause of mortality and disability globally. Understanding the role of chemokine-related differently expressed genes (CDGs) in ischemic stroke pathophysiology is essential for advancing diagnostic and therapeutic strategies. We conducted comprehensive analyses using the GSE16561 dataset: chemokine pathway enrichment via GSVA, differential expression of 12 CDGs, Pearson correlation, and functional enrichment analyses (GO and KEGG).

Review of Chinese species of genus Paramritodus Xue & Zhang (Hemiptera: Cicadellidae) with description of a new species.

The Chinese leafhopper species of the genus Paramritodus Xue & Zhang are reviewed. One new species, Paramritodus concavicaudus Zhang sp. nov.

The Characteristics and Clinical Analysis of Lorenz Plot of Neonatal Atrial Tachycardia.

Background: Lorenz plot (LP) analysis enhances the accuracy of arrhythmia diagnosis and serves as an attractive diagnostic tool for patients with arrhythmias. We explored the utility of the LP in the classification of various types of neonatal atrial tachycardia and evaluated the treatment effects and prognosis.

Methods: Ninety-six newborns with atrial tachycardia had their dynamic electrocardiograms and clinical data collected between January 2018 and June 2023.

Elucidating loss-of-function mechanisms of monoallelic EPAS1 mutations underlying congenital hypoplastic anaemia in a paediatric anaemia cohort.

HIF-2α, encoded by EPAS1, plays a dominant role in regulating erythropoietin (EPO) production, maintaining the dynamic balance of erythropoiesis. Gain-of-function mutations in EPAS1 cause erythrocytosis. However, anaemia caused by EPAS1 loss-of-function mutations has been confined to only one case report, and the underlying mechanism remains unclear.

Colorimetric aptasensors for sensitive low-density lipoprotein detection based on reduced oxide graphene@molybdenum disulfide-ferrocene nanosheets with peroxidase-like activity.

Low-density lipoprotein (LDL) is a key biomarker for cardiovascular disease (CVD) risk assessment. Monitoring LDL for the early diagnosis of CVD and its complications is an important clinical analysis tool. In this work, a novel colorimetric aptasensor for LDL detection was constructed reduced graphene oxide@molybdenum disulfide-ferrocene-carboxylic nanosheets (rGO@MoS-Fc) with excellent peroxidase-like activity.

Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding.

Objective: We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding.

Methods: Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed.

Fast standard error estimation for joint models of longitudinal and time-to-event data based on stochastic EM algorithms.

Maximum likelihood inference can often become computationally intensive when performing joint modeling of longitudinal and time-to-event data, due to the intractable integrals in the joint likelihood function. The computational challenges escalate further when modeling HIV-1 viral load data, owing to the nonlinear trajectories and the presence of left-censored data resulting from the assay's lower limit of quantification. In this paper, for a joint model comprising a nonlinear mixed-effect model and a Cox Proportional Hazards model, we develop a computationally efficient Stochastic EM (StEM) algorithm for parameter estimation.

Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition.

Background: Hyperuricemia is independently associated with a poor prognosis in patients with myocardial infarction (MI). Furthermore, MI induces activation of the repair response in local fibroblasts, resulting in extracellular matrix accumulation that generates a stable fibrotic scar in the infarcted area. However, researchers have not determined whether hyperuricemia affects fibroblast activation and its involvement in postinfarction cardiac remodeling.

Effects of remimazolam and surgery on cognition in a tibia fracture mouse model.

Background: To investigate the effects of remimazolam and surgery on cognitive function and neuropathology.

Methods: We performed intramedullary pin fixation of tibial fractures in wild-type male (12-13-week-old) C57BL/6J mice under intraperitoneal anesthesia with remimazolam. Age-matched wild-type control mice received either saline or remimazolam without surgery.

Delivery and kinetics of immersion optical clearing agents in tissues: Optical imaging from ex vivo to in vivo.

Advanced optical imaging provides a powerful tool for the structural and functional analysis of tissues with high resolution and contrast, but the imaging performance decreases as light propagates deeper into the tissue. Tissue optical clearing technique demonstrates an innovative way to realize deep-tissue imaging and have emerged substantially in the last two decades. Here, we briefly reviewed the basic principles of tissue optical clearing techniques in the view of delivery strategies via either free diffusion or external forces-driven advection, and the commonly-used optical techniques for monitoring kinetics of clearing agents in tissue, as well as their ex vivo to in vivo applications in multiple biomedical research fields.

Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways.

The objective of this study was to investigate the protective effect and potential mechanism of action of hemin on bleomycin-induced pulmonary fibrosis in mice. Male C57BL/6 mice were randomly divided into control, bleomycin and bleomycin + hemin groups. Mice in the bleomycin and bleomycin + hemin groups were injected intratracheally with bleomycin to establish the pulmonary fibrosis model.

Cepharanthine-mediated endoplasmic reticulum stress inhibits Notch1 via binding GRP78 for suppressing hepatocellular carcinoma metastasis.

Background: The metastasis of hepatocellular carcinoma (HCC) leads to a poor prognosis, wherein the activation of Notch1 is an essential contributor. Cepharanthine (Cep) has been identified for its effective antiviral function and versatile intracellular targets. Our previous study has only reported the anti-cancer efficacy of Cep in lung cancer, without an in-depth exploration.

Bibliometric Analysis of Research on Exercise Intervention for Cancer-Related Cognitive Impairments.

Cancer treatments frequently lead to cognitive impairments, affecting a substantial global population. Among various approaches, exercise has emerged as a promising strategy for rehabilitation. However, a comprehensive bibliometric analysis of research in this field is lacking.

Silicate Derived from for Removal of Polystyrene: Interfacial Effects of Living Organism and Its Derivatives with Nanoplastics.

The deposition of nanoplastics in the environment poses a direct threat to human health through the food chain. There is an urgent need to investigate how they can be effectively removed from water. In this work, the toxic effects of nanopolystyrene (PS) at different concentrations on (PT) were investigated.

Clinical and Genetic Profile of Chinese Children With Danon Disease: A Single-Center Retrospective Cohort Study.

Background: Danon disease (DD) is a rare X-linked dominant lysosomal storage disorder. Studies on DD pediatric patients are limited owing to the small number of cases and challenges in early detection.

Methods: We retrospectively analysed clinical and genetic data of 29 pediatric patients who visited our hospital for treatment or genetic counselling for DD from July 2014 to December 2023.