Publications by authors named "Tingting Shi"

Background: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in childhood. There is growing evidence that both preterm birth and maternal education levels substantially affect the likelihood of ADHD in children. However, there are limited systematic reviews and meta-analyses examining these associations.

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Background: Dupilumab inhibiting the signaling of interleukin(IL)-4 and IL-13 was recommended for the treatment of severe asthma in children ≥ 6 years old according to the Global Initiative for Asthma (GINA,2024).This study aimed to analyse the efficacy and safety of dupilumab in paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory disease in a real-world population.

Methods: We evaluated the medical records of paediatric patients with moderate-to-severe asthma and comorbid type 2 inflammatory diseases, such as atopic dermatitis (AD) and allergic rhinitis (AR), receiving dupilumab treatment.

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Esophageal carcinoma (EC) is one of the most common tumors in China and seriously affects patient survival and quality of life. In recent years, increasing studies have shown that the tumor microenvironment is crucial in promoting tumor progression and metastasis. Tumor-associated macrophages (TAM) are key components of the tumor immune microenvironment and promote both tumor growth and antitumor immunity.

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In this paper, a type of fractional-order two-layer network model is constructed, wherein each layer in the network exhibits distinct topology. Subsequently, the cluster synchronization problem of fractional-order two-layer networks is investigated through a two-step approach. The initial step involves the implementation of finite-time cluster synchronization in the first layer by utilizing a fractional-order finite-time convergence lemma.

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In spite of the considerable advancements achieved in enhancing the power conversion efficiency (PCE) of lead-based all-inorganic perovskite solar cells, there persists a need for materials that are both more stable and environmentally friendly. This investigation systematically explores the structural and thermodynamic stability, and electronic properties of Ge-based all-inorganic perovskite CsGeX (X = Cl, Br, I) in two space groups, 3̄ and 3, utilizing first-principles calculations. Introducing the novel concept of the "imaginary frequency coefficient" alongside the tolerance factor and stabilizing the chemical potential window, we collectively characterize the stability of CsGeX based on the phonon spectrum and phonon density of states calculations.

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Wide-bandgap perovskite sub-cells (WPSCs), one of the most crucial components of perovskite-based tandem solar cells (PTSCs), play a critical role in determining the performance of tandem devices. However, confined by the compromised crystallization properties of wide-bandgap perovskites, WPSCs exhibit significantly lower efficiency than their theoretical limit. In particular, for n-i-p structured all-inorganic WPSCs (AIWPSCs), severe nonradiative recombination due to the buried interface defects severely decreases the photovoltaic performance.

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Objective: To explore the genetic etiology of a pedigree with intellectual disability and explore its pathogenesis.

Methods: A Chinese pedigree which had presented at the Henan Provincial People's Hospital in March 2023 was selected as the study subject. Clinical data of the pedigree were collected, along with peripheral venous blood samples from its members.

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Saccharomyces cerevisiae L7 was found to be an excellent starter and biological deacidification strain for Suanyu, however, the underlying mechanisms remain poorly understood. This study aimed to investigate the acid inhibition mechanism of S. cerevisiae L7.

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Article Synopsis
  • * A large cohort of 9438 MetS patients was analyzed over an average follow-up period of about 107 months, where 1929 deaths were recorded, indicating a significant correlation between elevated SHR and higher mortality rates.
  • * The findings suggest a U-shaped relationship where both low and high SHR values may increase mortality risk, emphasizing the importance of monitoring SHR in managing MetS patients' health outcomes.
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Licorice flavonoids (LFs) exhibit potent antibacterial activities against Gram-positive bacteria. However, the related mechanism remains unclear. This study aims to illustrate the mechanisms of licochalcone A (LA), a main flavonoid in LFs, against methicillin-resistant (MRSA).

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Osmanthus fragrans has important ornamental and economic value. As the callus re-differentiation process is difficult, a genetic transformation system has not been successfully established in O. fragrans.

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Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%-15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades.

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  • Glycyrrhiza uralensis offers numerous health benefits, including detoxification, lung moisture, cough relief, spleen support, and medication balancing.
  • The study utilizes the Maximum Entropy (MaxEnt) model and random forest technique to analyze and simulate the potential distribution and classification of G. uralensis in Naiman Banner, revealing that its current planting area is less than its potential.
  • Findings from geographic information and remote sensing support better cultivation strategies, aiming to enhance the G. uralensis industry and contribute to rural revitalization while optimizing local ecological conditions.
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  • Two-dimensional MXene superconductors, especially 2D TiN materials, are gaining attention for their unique electronic properties and potential applications.
  • Researchers designed and analyzed two forms of hydrogenated TiN MXene (TiNH), focusing on their stability, electronic properties, and superconductivity.
  • The study found that TiNH has a superconducting critical temperature of 15.8 K, which can be increased to 18.7 K through strain engineering, highlighting the importance of electron-phonon interactions in this process.
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This article is concerned about fixed-time (FT) synchronization of spatiotemporal networks (STNs) with the Robin boundary condition. Above all, a switching-type FT stability theorem and an integral inequality are established, which provide a novel theoretical tool for the rigorous analysis of FT control in STNs. Subsequently, three kinds of nontrivial power-law controllers are developed which are separately acted on the interior, the boundary, and the whole of the spatial domain.

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The aim of this study was to investigate the potential mechanism by which cryptotanshinone(CTS) may exert its anti-myo-cardial ischemic effect through the regulation of macrophage polarization via the dendritic cell-associated C-type lectin 1(Dectin-1) signaling pathway. Male C57BL/6 mice, aged six weeks, were utilized to establish myocardial ischemia models and were subsequently divided into five groups: sham, model, CTS low-dose(21 mg·kg~(-1)·d~(-1)), CTS high-dose(84 mg·kg~(-1)·d~(-1)), and dapagliflozin(0.14 mg·kg~(-1)·d~(-1)).

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The capsule-associated protein 10 gene () is indispensable due to its involvement in pod formation and virulence maintenance in . The function of the gene in nematode-predatory fungi remains unreported. As a typical nematode-trapping fungus, efficiently captures nematodes using adhesive knobs, which has potential applications in the biological control of plant-parasitic nematodes.

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The clinical application of doxorubicin (DOX) was limited by the serious cardiotoxicity. The traditional Chinese medicine Andrographis paniculata and its principal active component (Dehydroandrographolide, DA) have been well known for their diverse cardiovascular protective effects. However, the effects of DA on DOX-induced cardiotoxicity (DIC) were still unknown.

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Article Synopsis
  • Pregnancy leads to significant changes in metabolism to support fetal growth, especially affecting adipose tissues.
  • During late pregnancy, mice showed increased insulin resistance and glucose intolerance, which improved after giving birth.
  • Different types of fat tissues adapted uniquely, with some showing decreased energy use and others increased lipid mobilization, suggesting a complex role in energy supply and potential risks for metabolic diseases in mothers.
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Background: The increasing demand for sustainable alternatives to traditional protein sources, driven by population growth, underscores the importance of protein in a healthy diet. Pecan (Carya illinoinensis (Wangenh.) K.

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Article Synopsis
  • - The oral microbiome plays a crucial role in maintaining oral health, and disruptions can lead to diseases; traditional toothpaste contains ingredients like sodium lauryl sulfate (SLS) and postbiotics to help with oral hygiene but their effects on the microbiome are not fully understood.
  • - The study revealed that SLS can harm oral bacteria by disrupting biofilms and increasing pathogenic bacteria, leading to tissue damage and inflammation, while postbiotic toothpaste promotes a healthier microbial environment and reduces conditions like periodontitis.
  • - Using postbiotic toothpaste alongside SLS can counteract its harmful effects, emphasizing the need for more research into how different toothpaste ingredients impact oral microbial health.
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Mannose-binding lectin (MBL) is a vital member of the lectin family, crucial for mediating functions within the complement lectin pathway. In this study, following the cloning of the mannose-binding lectin (MBL) gene in the ridgetail white prawn, Exopalaemon carinicauda, we examined its expression patterns across various tissues and its role in combating challenges posed by Vibrio parahaemolyticus. The results revealed that the MBL gene spans 1342 bp, featuring an open reading frame of 972 bp.

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  • - Researchers identified 13 OfYABBY genes in Osmanthus fragrans, classifying them into five subfamilies based on their genetic structure and protein motifs, indicating their role in plant development.
  • - OfYABBY12 was specifically studied through overexpression in tobacco, resulting in less release of key volatile compounds like β-ionone and affecting leaf structure and flower development.
  • - The findings suggest that the OfYABBY gene family plays a crucial role in the development of floral scents and influences leaf growth and morphology in O. fragrans.
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  • - The study explores the relationship between the triglyceride-glucose (TyG) index, a measure of insulin resistance, and myocardial ischemia in patients with ischemia and no obstructive coronary artery disease (INOCA), finding that a higher TyG index correlates with an increased occurrence of abnormal myocardial perfusion imaging (MPI).
  • - Out of 332 INOCA patients, 34% demonstrated abnormal MPI, and those in the highest TyG index group exhibited the highest rates of ischemia and major adverse cardiac events (MACE) during a follow-up period of approximately 35 months.
  • - The findings suggest that the TyG index could serve as a predictor for poor outcomes in INOCA patients, with higher
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Following the publication of the above paper, it was drawn to the Editors' attention by a concerned reader that the data obtained from sphere‑forming assay experiments shown in Figs. 4C‑F and 8B and C, and western blotting data in Figs. 4A and 8A, were strikingly similar to data appearing in different form in other articles by different authors from different research institutes that had already been published, one of which has been retracted.

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