An Outbreak of Foodborne Botulism Caused by BoNT/A3 in Pickled Eggs - Weihai City, Shandong Province, China, July 2024.

What Is Already Known About This Topic?: Foodborne botulism is caused by botulinum neurotoxin (BoNT). () is a strictly anaerobic, Gram-positive bacterium, which is a key pathogen capable of producing BoNT. BoNTs can be classified into seven serotypes (A to G) based on their antigenic properties.

Bioinspired peptide sensors with tailorable structure for specific and in-situ tracking of Hg biodistribution in living cells upon acute exposure.

Metal-biomolecule interactions that are ubiquitous in nature provide fundamental knowledge and rich structural motifs for the development of functional molecules and smart sensors. In this work, inspired by the active sites in metalloproteins, a biomimetic peptide sensor was designed for the selective recognition and activatable sensing of Hg in living biosystems. Tetraphenylethylene (TPE) with typical aggregation-induced emission (AIE) behavior, was introduced as the activatable signal transducer to enable high signal-to-background signaling.

Type 3 resistant starch from Canna edulis reduce lipid levels in patients with mild hyperlipidemia through altering gut microbiome: A double- blind randomized controlled trial.

Type 3 resistant starch from Canna edulis (Ce-RS3) is an insoluble dietary fiber which could improve blood lipids in animals, but clinically robust evidence is still lacking. We performed a double-blind randomized controlled trial to assess the effects of Ce-RS3 on lipids in mild hyperlipidemia. One hundred and fifteen patients were included followed the recruitment criteria, and were randomly allocated to receive Ce-RS3 or placebo (native starch from Canna edulis) for 12 weeks (20 g/day).

Arabidopsis ERD15 regulated by BBX24 plays a positive role in UV-B signaling.

Ultraviolet-B (UV-B, 280-315 nm) is a minor component of solar radiation, but it has a major regulatory impact on plant growth and development. Solar UV-B regulates numerous aspects of plant metabolism, morphology and physiology through altering the expression of hundreds of genes. EARLY RESPONSIVE TO DEHYDRATION 15 (ERD15) is a drought-induced rapid response gene, formerly known as a negative regulator of the abscisic acid (ABA) signaling pathway.

Genomic surveillance of SARS-CoV-2 in Weihai, China, march 2022 to march 2023.

COVID-19 is an acute respiratory infectious disease caused by SARS-CoV-2. It was first reported in Wuhan, China in December 2019 and rapidly spread globally in early 2020, triggering a global pandemic. In December 2022, China adjusted the dynamic COVID-zero strategy that lasted for three years.

Manipulation of Spin-Orbit Torque in Tungsten Oxide/Manganite Heterostructure by Ionic Liquid Gating and Orbit Engineering.

Spin-orbit coupling (SOC) is the interaction between electron's spin and orbital motion, which could realize a charge-to-spin current conversion and enable an innovative method to switch the magnetization by spin-orbit torque (SOT). Varied techniques have been developed to manipulate and improve the SOT, but the role of the orbit degree of freedom, which should have a crucial bearing on the SOC and SOT, is still confusing. Here, we find that the charge-to-spin current conversion and SOT in WO/(La, Sr)MnO could be produced or eliminated by ionic liquid gating.

Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence.

Specific identification and monitoring of senescent cells are essential for the in-depth understanding and regulation of senescence-related life processes and diseases. Fluorescent sensors providing real-time and in situ information with spatiotemporal resolution are unparalleled tools and have contributed greatly to this field. This review focuses on the recent progress in fluorescent sensors for molecularly targeted imaging and real-time tracking of cellular senescence.

Control of Compensation Temperature in CoGd Films through Hydrogen and Oxygen Migration under Gate Voltage.

Electrical control of magnetic properties is crucial for low-energy memory and logic spintronic devices. We find that the magnetic properties of ferrimagnetic CoGd can be altered through ionic liquid gating. Gate voltages manipulate the opposite magnetic moments in Co and Gd sublattices and induce a giant magnetic compensation temperature change of more than 200 K in Pt/CoGd/Pt heterostructures.

Electrical Control of Spin Hall Efficiency and Field-Free Magnetization Switching in W/Pt/Co/Pt Heterostructures with Competing Spin Currents.

Reversal of magnetization via current-induced spin-orbit torque (SOT) is one of the core issues in spintronics. However, an in-plane assistant field is usually required for the deterministic switching of a perpendicularly magnetized system. Additionally, the efficiency of SOT is low, which is detrimental to device applications.

Wnt4 prevents apoptosis and inflammation of dental pulp cells induced by LPS by inhibiting the IKK/NF‑κB pathway.

Wnt4 has been shown to promote the recovery of odontogenic differentiation of dental pulp stem cells under inflammatory conditions, but its role in inflammation and apoptosis of pulpitis remains to be elucidated. Lipopolysaccharide (LPS) (10 µg/ml) was applied to treat the human dental pulp cells (HDPCs) for 24 h. Western blotting measured the expressions of inflammatory cytokines and apoptosis-related proteins.

HPV 16 E6 promotes growth and metastasis of esophageal squamous cell carcinoma cells in vitro.

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies worldwide. Increasing evidence suggests that human papillomavirus (HPV) infection may be associated with the etiology of ESCC. However, the precise role of HPV in ESCC remains unclear.

Construction of a MOF-Supported Palladium Catalyst via Metal Metathesis.

A new MOF-supported heterogeneous palladium catalyst Pd/NBB-1 has been synthesized successfully through the effective metal metathesis between Pd(CF COO) and NBB-1. NBB-1 is a two-dimensional zinc metal-organic framework constructed from 2-aminoterephthalate (NH -H BDC) and 2,2'-bipyridine-5-carboxylate (HBPC) by solvothermal method. The replacement efficiency of Pd(II) to Zn(II) is up to 72% after only 24 hours, which is beneficial to the catalytic application.

MOF-Derived Pt/ZrO Carbon Electrocatalyst for Efficient Hydrogen Evolution.

One type of porous carbon nanomaterial decorated by abundant Pt/ZrO nanoparticles can be conveniently prepared, which is pyrolyzed from flower-shaped Zr-based UiO-67 precursor with a small amount of HPtCl molecules in its large pores. In addition, the obtained Pt/ZrO carbon electrocatalyst can bring efficient electrocatalytic hydrogen evolution performance and long-term stability.

Regulation of gene in WU14 mediated by GlnR.

Nitrogen (N) is an essential element in the biosynthesis of key cellular components, such as proteins and nucleic acids, in all living organisms. Nitrite, as a form of nitrogen utilization, is the main nutrient for microbial growth. However, nitrite is a potential carcinogen that combines with secondary amines, which are breakdown products of proteins, to produce N-nitroso compounds that are strongly carcinogenic.

Electrical Control of Spin Hall Effect in Pt by Hydrogen Ion Adsorption and Desorption.

The manipulation of charge-to-spin current conversion and spin-orbit torque (SOT) is of great interest due to its profound physics and potential applications. Controlling the spin current through the electric field provides a perspective for highly efficient SOT devices. Here, we use HO-doped ionic liquid gating to realize the reversible and nonvolatile manipulation of the spin Hall effect of Pt, and the spin Hall angle can be modulated by 48% within an accessible gate voltage range.

BBX24 Interacts with DELLA to Regulate UV-B-Induced Photomorphogenesis in .

UV-B radiation, sensed by the photoreceptor UVR8, induces signal transduction for plant photomorphogenesis. UV-B radiation affects the concentration of the endogenous plant hormone gibberellin (GA), which in turn triggers DELLA protein degradation through the 26S proteasome pathway. DELLA is a negative regulator in GA signaling, partially relieving the inhibition of hypocotyl growth induced by UV-B in Arabidopsis thaliana.

Electrical and thermal transport properties of high crystalline PdTe nanoribbons under a strong magnetic field.

The low-temperature superconductivity and topological properties of two-dimensional PdTe have shown great potential in the fields of optics and electronics, and its electrical and thermal transport properties under a strong magnetic field are very important for basic research and practical applications. In this study, the electrical resistivity and thermal conductivity of high crystalline PdTe nanoribbons were comprehensively measured by applying the direct current heating method, eliminating the thermal and electrical contact resistances at different magnetic field intensities and temperatures. It is found that the PdTe nanoribbons exhibited a low electrical resistivity of ∼27 μΩ cm and a high thermal conductivity of ∼130 W m K at room temperature.

The involvement of branched-chain amino acids (BCAAs) in aromatic trihalogenated DBP exposure-induced kidney damage in mice.

Disinfection by-products (DBPs) are inevitably generated in the process of disinfection. Among them, aromatic halogenated DBPs, such as 2,4,6-trichlorophenol (TCP), 2,4,6-tribromophenol (TBP) and 2,4,6-triiodophenol (TIP), have attracted considerable interest for their high toxicity. A systematic nephrotoxicity evaluation of 2,4,6-trihalophenols is still lacking.

Dietary Nutrition and Gut Microbiota Composition in Patients With Hypertensive Disorders of Pregnancy.

Objective: The aim is to explore the intakes of dietary nutrients and the changes of gut microbiota composition among patients with hypertensive disorders of pregnancy (HDP) and provide a theoretical basis for the prevention and treatment of HDP.

Methods: This study was conducted at the Maternal and Child Health Care Hospital of Changzhou. A total of 170 pregnant women (72 patients with HDP in the case group and 98 healthy pregnant women in the control group) in the third trimester were enrolled.

Depletion of gut secretory immunoglobulin A coated is associated with gestational diabetes mellitus-related intestinal mucosal barrier damage.

Changes in secretory immunoglobulin A (SIgA) coated bacteria from early to late pregnancy were associated with the development of gestational diabetes mellitus (GDM). SIgA coated beneficial gut bacteria, which are depleted in GDM, are potential probiotics for the prevention of GDM. We investigated blood biochemistry, chronic inflammation, mucosal barrier biomarkers and faecal SIgA coated microbiota in healthy early pregnancy (T1H, = 50), late pregnancy (T3H, = 30) and women with GDM (T3D, = 27).

Gibberellin regulates UV-B-induced hypocotyl growth inhibition in .

Plant response to light is a complex and diverse phenomenon. Several studies have elucidated the mechanisms via which light and hormones regulate hypocotyl growth. However, the hormone-dependent ultraviolet-B (UV-B) response in plants remains obscure.

Decrease in abundance of bacteria of the genus in gut microbiota may be related to pre-eclampsia progression in women from East China.

Background: Pre-eclampsia (PE) can result in severe damage to maternal and fetal health. It has been reported that gut microbiota (GM) had important roles in regulating the metabolic and inflammatory responses of the mother. However, investigations on GM in PE are rare.

Chemical Synthesis and Integration of Highly Conductive PdTe with Low-Dimensional Semiconductors for p-Type Transistors with Low Contact Barriers.

Low-dimensional semiconductors provide promising ultrathin channels for constructing more-than-Moore devices. However, the prominent contact barriers at the semiconductor-metal electrodes interfaces greatly limit the performance of the obtained devices. Here, a chemical approach is developed for the construction of p-type field-effect transistors (FETs) with low contact barriers by achieving the simultaneous synthesis and integration of 2D PdTe with various low-dimensional semiconductors.

CXCL1 Recruits NK Cells Into the Central Nervous System and Aggravates Brain Injury of Mice Caused by Infection.

Background: (), is a food-borne zoonotic parasite that can cause central nervous system (CNS) injury characterized by eosinophilic meningitis. However, the pathogenesis of angiostrongylosis remains elusive. Natural killer cells (NK cells) are unique innate lymphocytes important in early defense against pathogens.