High prevalence and plasmidome diversity of -positive enterococci in a Shenzhen community, China.

Background: The emergence of , which can confer resistance to phenicols and oxazolidinones in spp., poses a growing public health threat.

Methods: 102 -positive enterococci (OPEs) including various species were isolated from feces of 719 healthy volunteers in a Shenzhen community, China.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

A series of isostructural polyoxometalate-based metal-organic frameworks of 3,5-bis(1',2',4'-triazol-1'-yl)pyridine: synthesis, structures and electrocatalytic properties.

Three isostructural polyoxometalate-based metal-organic frameworks (POMOFs) [MII2(btap)(β-MoO)(HO)]·4HO (M = Co 1, Ni 2, Zn 3) based on octamolybdate and 3,5-bis(1',2',4'-triazol-1'-yl)pyridine (btap) were synthesized the hydrothermal method. POMOFs 1 and 2 and their thermal derivatives could be utilized as efficient electrocatalysts for the oxygen evolution reaction.

The Hippo Pathway in Breast Cancer: The Extracellular Matrix and Hypoxia.

As one of the most prevalent malignant neoplasms among women globally, the optimization of therapeutic strategies for breast cancer has perpetually been a research hotspot. The tumor microenvironment (TME) is of paramount importance in the progression of breast cancer, among which the extracellular matrix (ECM) and hypoxia are two crucial factors. The alterations of these two factors are predominantly regulated by the Hippo signaling pathway, which promotes tumor invasiveness, metastasis, therapeutic resistance, and susceptibility.

Outer-surface covering of nanochannels with hydrogel for anti-protein-interference on the ion current.

Nanopore/nanochannel sensing is a promising analytical method in the fields of chemistry and biology. However, due to the interference of non-analytes in complex samples, directly analyzing un-pretreated samples through nanopores/nanochannels remains a great challenge. Here, we report a type of heterogeneous membrane by covering anodic aluminum oxide (AAO) cylindrical nanochannel porous membrane with graphene oxide/calcium alginate (GCA) hybrid hydrogel to reduce the interference of protein on the current detection signal.

Extremely efficient catalytic ozonation of ammonia N to N using Co/Mg(OH) as catalysts.

The development of highly efficient and selective ozonation catalysts is crucial for enhancing the treatment of nitrogen-containing wastewater. In this study, a Co/Mg(OH) nano-hexagonal sheets ozonation catalyst was prepared by one-pot hydrothermal method, and the structural characteristics of this catalyst were comprehensively analyzed. The O/O ratio of this catalyst was 41.

The Russia-Ukraine conflict, soaring international energy prices, and implications for global economic policies.

This study examines the economic impact of soaring international energy prices during the Russia-Ukraine conflict from February 23, 2022, to May 31, 2022. Notably, by applying a CGE model, this study offers insights into energy policies at both macroeconomic and industrial levels, emphasizing the model's utility in analyzing complex economic interactions under geopolitical stress. Findings indicate that: , faced severe economic setbacks due to sanctions, with its GDP contracting by 5.

Serum arsenic augments gallstone risk in Henan rural cohort with multiple metal exposure.

Background: People are exposed to metals in various ways during their daily lives. However, the association between metal exposure and gallstones remains unclear.

Objectives: To investigate the relationship between serum elemental concentrations and the risk of gallstones.

Biochar amendment alleviates soil microbial nitrogen and phosphorus limitation and increases soil heterotrophic respiration under long-term nitrogen input in a subtropical forest.

Nitrogen (N) and carbon (C) inputs substantially affect soil microbial functions. However, the influences of long-term N and C additions on soil microbial resource limitation and heterotrophic respiration-fundamental microbial functional traits-remain unclear, impeding the understanding of how soil C dynamics respond to global change. In this study, the responses of soil microbial resource limitation and heterotrophic respiration (Rh) to 7-year N and biochar (BC) additions in a subtropical Moso bamboo (Phyllostachys edulis) plantation were investigated.

In-situ rapid cultivation of aerobic granular sludge in A/O bioreactor by using Ca(ClO) pretreating sludge.

The efficient utilization of residual sludge and the rapid cultivation of aerobic granular sludge in continuous-flow engineering applications present significant challenges. In this study, aerobic granular cultivation was fostered in a continuous-flow system using Ca(ClO)2-sludge carbon (Ca-SC). Ca-SC retained the original sludge properties, contributing to granular growth in an A/O bioreactor.

Do social economic status modify the association between air pollution and depressive or anxiety symptoms? A big sample cross-sectional study from the rural areas of Central China.

Background: Fewer studies have examined the relationship between air pollution and depressive or anxiety symptoms in rural residents. Social economic status (SES), as an important indicator of the current state of socioeconomic development, we know little about how it modifies the relationship between air pollution and symptoms of depression or anxiety.

Methods: The patient health questionnaire (PHQ-2) and generalized anxiety scale (GAD-2) were used to learn about the prevalence of depressive and anxiety symptoms, the social economic status of the participants was categorized into two levels: lower and higher, and a binary logistic regression model was used to analyze the relationship between air pollution and residents' symptoms of depression or anxiety.

Relationship between Sjogren's syndrome and gastroesophageal reflux: A bidirectional Mendelian randomization study.

The clinical incidence of sjogren's syndrome combined with gastroesophageal reflux disease is high. Existing observational studies have shown inconsistent results in the association between gastroesophageal reflux disease (GERD) and Sjogren's syndrome (SS).We observed that the symptoms of SS patients also improved after receiving GERD-related treatment.

Artemisinin and its derivatives modulate glucose homeostasis and gut microbiota remodeling in a nutritional context.

Glucose metabolic disorders, prevalent in numerous metabolic diseases, have become a pressing global public health concern. Artemisinin (ART) and its derivatives, including artesunate (ARTs) and artemether (ARTe), have shown potential as metabolic regulators. However, the specific effects of ART and its derivatives on glucose metabolism under varying nutritional conditions and the associated molecular mechanisms remain largely unexplored.

Total Synthesis of Brevitaxin.

Brevitaxin was prepared in nine steps from commercially available carnosic acid. The construction of the 1,4-benzodioxin moiety involved an unique stepwise -quinone-engaged [4+2] cycloaddition. Two strategic stages were employed to prepare the highly unsaturated cycloaddition precursor : (1) synthesizing the diene moiety (C1-C2 and C10-C20 double bonds) by regioselective -quinone tautomerization, and (2) installing four 2-hybridized carbon atoms (C3, C5, C6 and C7) in one step using a SeO-promoted chemo- and regioselective oxidation reaction.

Modified peroral endoscopic myotomy technique with retrograde on-demand myotomy for achalasia: a retrospective cohort study (with video).

Background: Although myotomy is crucial in peroral endoscopic myotomy (POEM) surgeries, its optimum length remains controversial. Herein, we propose a modified POEM with new method of tailoring myotomy length aim to evaluate the safety, efficacy, and clinical outcomes of this modified POEM compared with standard POEM in type I or II achalasia.

Methods: Seventy-five patients with type I or II achalasia who underwent POEM at the First Hospital of Jilin University between January 2018 and December 2022 were retrospectively analyzed.

Regulatory networks of senescence-associated gene-transcription factors promote degradation in Moso bamboo shoots.

Bamboo cultivation, particularly Moso bamboo (Phyllostachys edulis), holds significant economic importance in various regions worldwide. Bamboo shoot degradation (BSD) severely affects productivity and economic viability. However, despite its agricultural consequences, the molecular mechanisms underlying BSD remain unclear.

Spermidine-Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ.

The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN-SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non-dynamic photo-crosslinked bonds respectively. The single network hydrogel before photo-crosslinking exhibits excellent injectability and thus can be printed and photo-crosslinked in situ to form double network hydrogels.

Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis.

Sjogren's syndrome (SS) is an autoimmune disease characterized by dysfunction of exocrine glands, such as salivary glands. However, the molecular mechanism of salivary secretion dysfunction in SS is still unclear. Given the significance of glutathione peroxidase 4 (GPX4) in cellular redox homeostasis, we hypothesized that dysregulation of GPX4 may play a pivotal role in the pathogenesis of salivary secretion dysfunction observed in SS.

The impact of COVID-19 pandemic on the world's major economies: based on a multi-country and multi-sector CGE model.

Objective: To quantitatively assess the impact of COVID-19 pandemic on public health, as well as its economic and social consequences in major economies, which is an international public health concern. The objective is to provide a scientific basis for policy interventions.

Subject And Methods: This study utilizes a multi-country, multi-sector CGE-COVID-19 model to analyze the repercussions of the pandemic in 2022.

CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis.

Background: Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly affects exocrine glands. Previous studies have demonstrated that upregulated interferon-gamma (IFN-γ) in SS triggers ferroptosis in salivary gland epithelial cells (SGECs), resulting in impaired salivary gland secretion. However, the immune cells responsible for secreting IFN-γ remain unclear.

Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi-targets against osteoarthritis via network pharmacological analysis and experimental validation.

Objective: Our purpose is to unveil Andrographolide's potential multi-target and multi-mechanism therapeutic effects in treating OA via systematic network pharmacological analysis and cell experimental validation.

Materials And Methods: Initially, we gathered data from Andrographolide and OA-related databases to obtain information on Andrographolide's biological properties and the targets linked with OA. We developed a bioinformatic network about Andrographolide and OA, whereby we analyzed the network to identify potential therapeutic targets and mechanisms of action of Andrographolide.

Nitrogen fertilization practices alter microbial communities driven by clonal integration in Moso bamboo.

Nitrogen (N) fertilization is crucial for maintaining plant productivity. Clonal plants can share resources between connected ramets through clonal integration influencing microbial communities and regulating soil biogeochemical cycling, especially in the rhizosphere. However, the effect of various N fertilization practices on microbial communities in the rhizosphere of clonal ramets remain unknown.