Publications by authors named "Tingsang Chen"
Article Synopsis
- The study aimed to evaluate the effectiveness of metagenomic next generation sequencing (mNGS) compared to traditional methods like fungal culture, (1,3)-β-D glucan (G) test, and galactomannan (GM) test in diagnosing invasive pulmonary aspergillosis (IPA).
- A total of 136 patients were analyzed, with 66 diagnosed with IPA, and mNGS showed a sensitivity of 53.03%, outperforming the other traditional tests which had lower sensitivities. Combining these tests increased the overall diagnostic sensitivity to 69.70%.
- The findings indicate that mNGS is a more effective diagnostic tool for IPA, especially in analyzing specific samples, and its
To determine the role of inflammation-related proteins in predicting asthma severity and outcome, 92 inflammation-related proteins were measured in the asthmatic serum using Olink analysis. Different bioinformatics algorithms were developed to cross analyze with the single-cell or transcriptome data sets from the Gene Expression Omnibus database to explore the role of IL18R1 and related genes in asthma and idiopathic pulmonary fibrosis (IPF). Olink identified 52 differentially expressed proteins in asthma.
View Article and Find Full Text PDFRegulatory T cell activity in immunosuppresive mice model of pseudomonas aeruginosa pneumonia.
J Huazhong Univ Sci Technolog Med Sci
August 2017
Pseudomonas aeruginosa (PA) pneumonia is a refractory, even lethal complication in immunosuppressive individuals and immune disturbances may promote the pathological process. We aimed to investigate the regulatory T (Treg) cell activity in an immunosuppressive mice model of PA pneumonia by estimating levels of main transcription factor and the main effector of Treg cells, i.e.
View Article and Find Full Text PDFAim: The present study aimed to investigate the effect of intravenous immunoglobulin (IVIG) on regulatory T (Treg) cells derived from immunosuppressed mice with Pseudomonas aeruginosa (PA) pneumonia.
Methods: A total of 108 BALB/c mice were randomly divided into the following groups: control group (Control), immunosuppressed group (IS), PA pneumonia group (PA), PA pneumonia in immunosuppressed group (IS + PA), PA pneumonia with IVIG treatment in immunocompetent group (PA + IVIG) and PA pneumonia with IVIG treatment in immunosuppressed group (IS + PA + IVIG). Each group comprised 18 mice.
Article Synopsis
- * Key clinical features include high eosinophil levels, deep vein thrombosis, pulmonary embolism, low platelet count, and recurrent bone cysts with bone destruction.
- * Histological examination shows eosinophilic infiltration and tissue necrosis in the bone cysts, suggesting hypereosinophilia may contribute to both thrombosis and bone damage.