Publications by authors named "Tingruo Zhang"
Article Synopsis
- RNA N4-acetylcytidine (ac4C) modification is significant for gene regulation, but its role in pain regulation is unexplored; this study identifies NAT10 as a key player in neuropathic pain.
- After peripheral nerve injury, NAT10 expression increases due to USF1 activation, leading to elevated ac4C levels in dorsal root ganglia (DRGs).
- Silencing or deleting NAT10 reduces pain sensitivity in nerve-injured mice, while its upregulation without injury induces pain behaviors, indicating that NAT10-targeted ac4C could be a therapeutic target for neuropathic pain treatment.
