Publications by authors named "Tingquan Zheng"
Asparaginyl ligases have been extensively utilized as valuable tools for site-specific bioconjugation or surface-modification. However, the application is hindered by the laborious and poorly reproducible preparation processes, unstable activity and ambiguous substrate requirements. To address these limitations, this study employed a structure-based rational approach to obtain a high-yield and high-activity protein ligase called OaAEP1-C247A-aa55-351.
View Article and Find Full Text PDFTo assess the pattern of multiple human papillomavirus infection to predict the type replacement postvaccination. A total of 7372 women aged 18-45y from a phase III trial of an -produced HPV-16/18 vaccine were analyzed at enrollment visit before vaccination. Hierarchical multilevel logistic regression was used to evaluate HPV vaccine type and nonvaccine-type interactions with age as a covariate.
View Article and Find Full Text PDFArticle Synopsis
- A study compared the immunogenicity of a new HPV vaccine, Cecolin 9, produced by E. coli, with the established Gardasil 9, focusing on various HPV types including 6, 11, 16, 18, and others.
- Conducted in China, the randomized trial included 487 healthy women aged 18-26, who received three doses of either vaccine, and measured antibody responses to determine effectiveness.
- Results showed both vaccines achieved a 100% seroconversion rate, with Cecolin 9 demonstrating comparable or superior antibody levels for several HPV types, suggesting it may be an effective alternative to Gardasil 9.