Exploring the homing effect and enhanced drug delivery potential of small extracellular vesicles.

We propose a strategy of assembling small extracellular vesicles (sEVs) and liposomes into dimers to explore the homing effect and the drug delivery potential of sEVs. The uptake rate of dimers by parental cells is 2.6-4.

Engineering small extracellular vesicles with multivalent DNA probes for precise tumor targeting and enhanced synergistic therapy.

Small extracellular vesicles (sEVs) have gained wide attention as efficient carriers for disease treatment. However, the proclivity of sEVs to be ingested by source cells is insufficient to accurately target specific sites, posing a challenge in realizing controlled targeting treatment. Here, we developed an engineered sEV nanocarrier capable of precise tumor targeting and enhanced synergistic therapy.

Advances of machine learning-assisted small extracellular vesicles detection strategy.

Detection of extracellular vesicles (EVs), particularly small EVs (sEVs), is of great significance in exploring their physiological characteristics and clinical applications. The heterogeneity of sEVs plays a crucial role in distinguishing different types of cells and diseases. Machine learning, with its exceptional data processing capabilities, offers a solution to overcome the limitations of conventional detection methods for accurately classifying sEV subtypes and sources.

Timing of systemic resistance induced by local exogenous ABA application within clonal network of stoloniferous herb subjected to low water availability.

Resistance traits of plants can be activated both at the damaged site and undamaged parts. Systemic resistance induced by local exogenous abscisic acid (ABA) application alleviated negative effect of low water availability on growth performance of clonal plant. However, timing of systemic resistance was poorly understood.

Osmotic Adjustment and Antioxidant System Regulated by Nitrogen Deposition Improve Photosynthetic and Growth Performance and Alleviate Oxidative Damage in Dwarf Bamboo Under Drought Stress.

Dwarf bamboo () is a staple food for the endangered giant pandas and plays a critical role in the sub-alpine ecosystem. Characterized by shallow roots and expeditious growth, it is exceedingly susceptible to drought stress and nitrogen (N) deposition in the context of a changing global environment. However, a comprehensive picture about the interactive response mechanism of dwarf bamboo to the two factors, water regime and N deposition, is far from being given.