Associations of genetic polymorphisms with clinical response to tocilizumab in Chinese rheumatoid arthritis patients.

Objective: To examine the associations of single-nucleotide polymorphisms (SNPs) within interleukin-6 (IL6) and IL-6 receptor (IL6R) as well as several potential SNPs revealed in a genome-wide association study (GWAS) with clinical response to tocilizumab (TCZ) in Chinese rheumatoid arthritis (RA) patients.

Methods: A total of 23 SNPs were genotyped in 68 RA patients receiving intravenous TCZ, who were prospectively followed for 6 months to determine the clinical response based on several criteria, including clinical disease activity index (CDAI) low disease activity (LDA) and remission, disease activity score in 28 joint counts - erythrocyte sedimentation rate (DAS28-ESR) LDA and remission, European League Against Rheumatism (EULAR) good response and change in DAS28-ESR (ΔDAS28-ESR).

Results: The patients were on average 51.

Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties.

Background: Chickens are one of the most widely farmed animals worldwide and play a crucial role in meat and egg production. Gut microbiota is essential for chickens' health, disease, growth, and egg production. However, native chickens such as Jianghan chickens have better meat and egg production quality than centralized chickens, their intestinal microbial diversity is richer, and the potential gut microbial resources may bring health benefits to the host.

Evaluation of cholesterol transformation abilities and probiotic properties of YGMCC0564.

Hypercholesterolemia, a risk factor for cardiovascular disease (CVD), often requires therapeutic agents with varying degrees of side effects. This has created a need for safe and natural alternatives such as medications or functional foods that can improve lipid metabolism and reduce cholesterol levels. In recent years, Next-generation probiotics (NGPs) have recently emerged as a potential solution, offering distinct mechanisms compared to traditional probiotics.

Thermally-Induced Isomerization of Prenucleation Clusters During the Prenucleation Stage of CdTe Quantum Dots.

The evolution of prenucleation clusters in the prenucleation stage of colloidal semiconductor quantum dots (QDs) has remained unexplored. With CdTe as a model system, we show that substances form and isomerize prior to the nucleation and growth of QDs. Called precursor compounds (PCs), the prenucleation clusters are relatively optically transparent and can transform to absorbing magic-size clusters (MSCs).

The Indoor Predictability of Human Mobility: Estimating Mobility with Smart Home Sensors.

Analyzing human mobility patterns is valuable for understanding human behavior and providing location-anticipating services. In this work, we theoretically estimate the predictability of human movement for indoor settings, a problem that has not yet been tackled by the community. To validate the model, we utilize location data collected by ambient sensors in residential settings.

Clinical analysis of 175 cases of vaginal intraepithelial neoplasia.

Objective: To evaluate the risk factors related to vaginal intraepithelial neoplasia (VaIN) severity.

Study Design: This retrospective study included patients with histologically confirmed VaIN diagnosed at Hubei Provincial Maternal and Child Health Hospital, China, between January 2017 and October 2021. The primary outcomes were persistence, remission, progression, and recurrence.

Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation.

Objective: Cervical cancer is linked with the constitutive activation of growth factors and gene mutations-induced pro-survival signaling pathways. Herein, we purposed to explore the possible molecular mechanism of Foxo3a-mediated DNMT3B in the proliferation and migration of cervical cancer cells via mediating the PTEN promoter methylation.

Methods: Foxo3a expression in cervical cancer was tested by qRT-PCR and western blot experiments.

The Interaction Mechanism of Fiscal Pressure, Local Government Behavioral Preferences and Environmental Governance Efficiency: Evidence from the Yangtze River Delta Region of China.

In environmental governance, local governments are the main actors, and their behavioral preferences between economic growth competition (EGC) and environmental regulation (ER) affect the inputs and outputs of environmental governance. Most studies discuss the relationship between government behaviors and the environment from the fiscal decentralization perspective, with few studies from the fiscal pressure (FP) perspective. Importantly, the bidirectional interaction mechanism is easily ignored.

Effects of dietary berberine on growth performance, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus) fed high-fat diets.

This study aimed to investigate the effects of high-fat diet (HFD) supplemented with berberine on growth, lipid metabolism, antioxidant capacity and lipometabolism-related genes expression of AMPK signaling pathway in juvenile black carp (Mylopharyngodon piceus). Five hundred and forty healthy fish (4.04 ± 0.

Protease or Clostridium butyricum addition to a low-protein diet improves broiler growth performance.

Low-protein (LP) feeds are used in the poultry industry to combat the increasing consumption of protein resources and reduce environmental pollution caused by excessive nitrogen excretion. Dietary supplementation of protease or Clostridium butyricum increases the growth performance of broilers; however, it is unclear whether they counteract the negative effects of LP diets. The effects of protease and C.

Intelligent Simulation of Water Temperature Stratification in the Reservoir.

In order to fully make use of limited water resources, humans have built many water conservancy projects. The projects produce many economic benefits, but they also change the natural environment. For example, the phenomenon of water temperature stratification often occurs in deep reservoirs.

Associations Between microRNA-related Genetic Polymorphisms and Clinical Response to Methotrexate in Chinese Rheumatoid Arthritis Patients.

Background: Emerging evidence indicates that microRNA (miRNA)-related genetic polymorphisms are strongly involved in the post-transcriptional regulation of the expression of pharmacokinetics and pharmacodynamics- related genes, therefore contributing to the genetic variability of drug response.

Objective: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients.

Methods: One hundred patients treated with MTX for approximately 3 months were prospectively followed up to evaluate the clinical response according to European League Against Rheumatism (EULAR) good and moderate response, disease activity score in 28 joint counts - erythrocyte sedimentation rate (DAS28-ESR) low disease activity (LDA) and remission (REM), change in DAS28-ESR (ΔDAS28-ESR) and ΔDAS28-ESR > 0.

Multiscale Characteristics and Drivers of the Bundles of Ecosystem Service Budgets in the Su-Xi-Chang Region, China.

Managing ecosystem services (ESs) to meet human needs is critical to achieving sustainable development in rapidly urbanizing regions. Identifying ES budget bundles and analyzing their drivers at a multiscale level can facilitate management decision-making; however, further research is required in areas undergoing rapid urbanization. This study quantified the supply, demand, and budgets of six typical ESs at the county, township, and village scales in the Su-Xi-Chang region in 2020.

OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway.

Cervical cancer is a common malignant tumor in females. Orthodenticle homolog 1 (OTX1) serves a key role in the occurrence and progression of tumors. The present study aimed to investigate the role and potential mechanism of OTX1 in cervical cancer.

Multi-Person Activity Recognition in Continuously Monitored Smart Homes.

Activity recognizers are challenging to design for continuous, in-home settings. However, they are notoriously difficult to create when there is more than one resident in the home. Despite recent efforts, there remains a need for an algorithm that can estimate the number of residents in the house, split a time series stream into separate substreams, and accurately identify each resident's activities.

Associations Between Genetic Polymorphisms Within Transporter Genes and Clinical Response to Methotrexate in Chinese Rheumatoid Arthritis Patients: A Pilot Study.

Purpose: To investigate the associations between genetic polymorphisms within transporter genes and clinical response to methotrexate (MTX) in Chinese rheumatoid arthritis (RA) patients.

Patients And Methods: A total of 100 RA patients receiving MTX were prospectively followed up for approximately 3 months to determine the clinical response based on several criteria, including European League Against Rheumatism (EULAR) good and moderate response, disease activity score in 28 joint counts - erythrocyte sedimentation rate (DAS28-ESR) low disease activity (LDA), change in DAS28-ESR (ΔDAS28-ESR) and ΔDAS28-ESR >0.6.

Assessment of genetic polymorphisms within nuclear factor-κB signaling pathway genes in rheumatoid arthritis: Evidence for replication and genetic interaction.

Objective: This study was performed to replicate the associations of genetic polymorphisms within nuclear factor-κB (NF-κB) signaling pathway genes with rheumatoid arthritis (RA), and to further examine genetic interactions in a Chinese population.

Methods: A total of eleven single-nucleotide polymorphisms (SNPs) were genotyped in 594 RA patients and 604 healthy controls.

Results: Genetic association analysis revealed that NFKBIE rs2233434, TNIP1 rs10036748 and BLK rs13277113 were significantly associated with RA, cyclic citrullinated peptide (CCP)-positive RA and rheumatoid factor (RF)-positive RA, and TNFAIP3 rs2230926 was significantly associated with CCP-positive RA.

Evolution of Two Types of ZnTe Magic-Size Clusters Displaying Sharp Doublets in Optical Absorption.

The two-pathway model proposed for colloidal semiconductor metal chalcogenide (ME) quantum dots (QDs) and magic-size clusters (MSCs) is demonstrated for ZnTe. Two new types of ZnTe MSCs have been found, which exhibit sharp optical absorption doublets peaking at 356/389 and 389/420 nm. Labeled dMSC-389 and dMSC-420, respectively, they were produced from reaction mixtures in 1-octadecene (ODE) of zinc oleate (Zn(OA)), tri--octylphosphine telluride (TeTOP), diphenylphosphine (HPPh), and acetic acid (HOAc, CHCOOH).

Genetic association analysis of ATG16L1 rs2241880, rs6758317 and ATG16L2 rs11235604 polymorphisms with rheumatoid arthritis in a Chinese population.

Objective: This study was performed to test whether ATG16L1 rs2241880, rs6758317 and ATG16L2 rs11235604 polymorphisms were associated with RA and further examine the genetic interaction between ATG16L1 and ATG16L2 in RA among a Chinese population.

Methods: A total of 594 RA patients and 604 healthy controls were included, and the genetic polymorphisms were genotyped based on HI-SNP technology.

Results: Significant associations of ATG16L1 rs2241880 polymorphism with RA (T/T versus C/T + C/C, OR = 1.

Associations of genetic polymorphisms within , , and with genetic susceptibility to rheumatoid arthritis.

Recently, several long non-coding RNAs (lncRNAs) including MALAT1, UCA1, ENST00000483588, and ENST00000456270 have been implicated in the pathogenesis of rheumatoid arthritis (RA), and we hypothesized that polymorphisms within these lncRNA genes might be genetic modifiers for the development of RA. A total of 10 potentially functional single-nucleotide polymorphisms (SNPs) were selected and genotyped in 1198 participants, including 594 RA patients and 604 healthy controls. Significant associations of rs2882581 (G vs.

sMRT: Multi-Resident Tracking in Smart Homes With Sensor Vectorization.

Smart homes equipped with anonymous binary sensors offer a low-cost, unobtrusive solution that powers activity-aware applications, such as building automation, health monitoring, behavioral intervention, and home security. However, when multiple residents are living in a smart home, associating sensor events with the corresponding residents can pose a major challenge. Previous approaches to multi-resident tracking in smart homes rely on extra information, such as sensor layouts, floor plans, and annotated data, which may not be available or inconvenient to obtain in practice.

Body Mass Index and Clinical Response to Tocilizumab in Patients With Rheumatoid Arthritis.

Objectives: This study aims to determine whether baseline body mass index (BMI) affects clinical response to tocilizumab (TCZ) after six months of treatment in rheumatoid arthritis (RA) patients.

Patients And Methods: In this prospective study, a total of 52 RA patients (10 males, 42 females; mean age 50.6±12.

Plasma Long Non-Coding RNA Expression Profiles in Patients with Rheumatoid Arthritis.

Background: Recently, long non-coding RNAs (lncRNAs) have attracted substantial attention owing to their unforeseen critical roles in a wide range of biological processes. The aim of our study was to provide an overview of lncRNA expression profiles in plasma of RA patients.

Methods: The Agilent LncRNA + mRNA Human Gene Expression Microarray V4.

Real-Time Change Point Detection with application to Smart Home Time Series Data.

Change Point Detection (CPD) is the problem of discovering time points at which the behavior of a time series changes abruptly. In this paper, we present a novel real-time nonparametric change point detection algorithm called SEP, which uses Separation distance as a divergence measure to detect change points in high-dimensional time series. Through experiments on artificial and real-world datasets, we demonstrate the usefulness of the proposed method in comparison with existing methods.