Inhibitory effects of everolimus in combination with paclitaxel on adriamycin-resistant breast cancer cell line MDA-MB-231.

Objective: We aimed to evaluate the therapeutic effects of paclitaxel in combination with mTOR inhibitor everolimus on adriamycin-resistant breast cancer cell line MDA-MB-231 (MDA-MB-231/ADR).

Materials And Methods: MDA-MB-231/ADR cells were treated with different concentrations of paclitaxel and everolimus. The IC values after 48 h of treatment were measured by the MTT assay.

Stabilizing a high-voltage LiNiMnO cathode towards all solid state batteries: a Li-Al-Ti-P-O solid electrolyte nano-shell with a host material.

LiNi0.5Mn1.5O4 (LNMO) spinel has drawn increasing attention due to its high voltage, stabilized electrochemical performance and safety features as a cathode for lithium-ion batteries.

One-Step Integrated Surface Modification To Build a Stable Interface on High-Voltage Cathode for Lithium-Ion Batteries.

As one of the most promising cathode materials for next-generation energy storage applications, spinel LiNiMnO (LNMO) has been highlighted due to many advantages. However, it is still hindered by poor electrochemical stability derived from the bulk/interface structure degradation and side reactions under high working voltage. In this work, fast ion conductor LiV(PO) (LVPO) is adopted to modify the surface of spinel LNMO by a one-step facile method to harvest the maximum benefit of interface properties.

Integrated Surface Functionalization of Li-Rich Cathode Materials for Li-Ion Batteries.

As candidates for high-energy density cathodes, lithium-rich (Li-rich) layered materials have attracted wide interest for next-generation Li-ion batteries. In this work, surface functionalization of a typical Li-rich material LiMnNiCoO is optimized by fluorine (F)-doped LiSnO coating layer and electrochemical performances are also enhanced accordingly. The results demonstrate that F-doped LiSnO-modified material exhibits the highest capacity retention (73% after 200 cycles), with approximately 1.

Mutation of the light-induced yellow leaf 1 gene, which encodes a geranylgeranyl reductase, affects chlorophyll biosynthesis and light sensitivity in rice.

Chlorophylls (Chls) are crucial for capturing light energy for photosynthesis. Although several genes responsible for Chl biosynthesis were characterized in rice (Oryza sativa), the genetic properties of the hydrogenating enzyme involved in the final step of Chl synthesis remain unknown. In this study, we characterized a rice light-induced yellow leaf 1-1 (lyl1-1) mutant that is hypersensitive to high-light and defective in the Chl synthesis.

Nickel-catalyzed carboxylation of aryl and vinyl chlorides employing carbon dioxide.

Nickel-catalyzed carboxylation of aryl and vinyl chlorides employing carbon dioxide has been developed. The reactions proceeded under a CO(2) pressure of 1 atm at room temperature in the presence of nickel catalysts and Mn powder as a reducing agent. Various aryl chlorides could be converted to the corresponding carboxylic acid in good to high yields.

Emission enhancement and chromism in a salen-based gel system.

A new salicylideneaniline-based organogelator has been synthesized, and it can gelatinize organic solvents, including cyclohexane, toluene, benzene, and some mixed solvents. SEM images show that it has self-assembled into 1-D nanofibers, which further cross-link to form 3-D network. On the basis of the results of small-angle XRD and the optimized molecular length by semiempirical quantum calculations, the gelators are supposed to pack into a unimolecular lamellar structure with a period of 3.

Carbazole-based organogel as a scaffold to construct energy transfer arrays with controllable fluorescence emission.

A diaryldiketopyrrolopyrrole derivative functionalized with phenothiazine moieties (DPPP) was synthesized and introduced into the ordered 4-(3,6-di-tert-butyl-9H-carbazol-9-yl)benzamide (TBCB) organogel system. It was found that TBCB-based gel became a scaffold to make DPPP molecules line up along the gel fibers, resulting in new self-assembled arrays, whose XRD patterns were quite different from those of the neat TBCB gel and DPPP crystal. In the composite gel, the occurrence of a partial energy transfer from the excited light-harvesting antenna of TBCB to the DPPP acceptor was confirmed on the basis of time-dependent and time-resolved fluorescence investigations.

Porphyrins with four monodisperse oligocarbazole arms: facile synthesis and photophysical properties.

A series of novel monodisperse, well-defined, star-shaped molecules T(OCAn)Ps (n = 2-6) with a central porphyrin core and four oligocarbazole arms are synthesized from the corresponding formyl-substituted oligocarbazoles via Adler reaction. The obtained star-shaped porphyrins are intrinsically two-dimensional nanosized molecules, and the diameter of compound T(OCA6)P is 7.4 nm, representing one of the largest known star-shaped conjugated systems.

Novel carbazole-based organogels modulated by tert-butyl moieties.

tert-Butyl groups can modulate the self-assembling properties of carbazole derivatives; organogel fibers with a bright blue emission are generated, directed by the cooperation of hydrogen bonding as well as pi-pi interactions.

Phosphorus(V) porphyrins with axial carbazole-based dendritic substituents.

[structure: see text] Three phosphorus(V) porphyrins with axial carbazole-based dendritic substituents (D-A-D) have been designed and synthesized, which are nonfluorescent due to their effective electron transfer from the carbazole dendron to the excited porphyrin within the dendritic matrix. The incident photon to current conversion efficiencies (IPCE) spectra demonstrate that the molecular structure of the dendrimers can significantly affect the photovoltaic response to the visible light.

Triphenyl benzene-bridged fluorescent silsesquioxane: shape-controlled hybrid silicas by hydrolytic conditions.

A new silsesquioxane molecule was synthesized, in which triphenyl benzene was connected with three Si(OC2H5)3 groups using three urea groups as the bridge. The molecule could self-assemble through the intermolecular H-bonding among urea groups and pi-pi interaction of triphenyl benzene core in the solution and it could also be transferred into hybrid silicas by hydrolysis. When the non-preorganized silsesquioxane was hydrolyzed, isolated spherical hybrid silica was gained.

Synthesis and self-assembly of dichalcone substituted carbazole-based low-molecular mass organogel.

We report the synthesis and self-assembly of a new pi-conjugated dichalcone substituted carbazole-based low molecular mass organogelator. It could form stable gels in most halogen-aromatic solvents. The transmission electron microscopy (TEM) images revealed that the gel formed fibrous structures with diameter of 50-100 nm, which consisted of several thinner fibers.

Helical stacking tuned by alkoxy side chains in pi-conjugated triphenylbenzene discotic derivatives.

We report on the synthesis and self-assembly of a new series of discotic molecules containing triphenylbenzene as the core and alkoxy side chain with varying length. It was found that compounds 3 a-c, 4 b and 5 b could form stable gels in several apolar solvents. Transmission electron microscopy (TEM) images revealed that their morphologies were very different for the different alkoxy-substituted organogels.