Publications by authors named "Tingdong Yu"
Application of integrin subunit genes in pancreatic cancer and the construction of a prognosis model.
J Gastrointest Oncol
October 2024
Article Synopsis
- Pancreatic adenocarcinoma (PAAD) is a challenging cancer with a low survival rate, and this study focuses on integrin subunit genes (ITGs) as potential prognostic markers for PAAD.
- The researchers utilized RNA-sequencing data and clinicopathological information to analyze ITG expression in PAAD, identifying 22 key ITGs linked to various cancer pathways.
- A prognostic model was developed based on these ITGs, revealing differences in immune cell proportions and gene expressions between high and low-risk PAAD groups, which could help in improving patient outcomes.
Background: Pancreatic cancer is a highly aggressive malignancy with poor prognosis, and there is an urgent need to understand its molecular mechanisms for early diagnosis and treatment. Despite surgical resection being the only effective treatment, most patients are diagnosed at an advanced stage, missing the optimal window for therapy. Identifying novel biomarkers is crucial for prognostic assessment, treatment planning, and early intervention.
View Article and Find Full Text PDFHepatocellular cancer is one of the most serious types of cancer in the world, with high incidence and mortality rates. Most HCC patients with long-term chemotherapy develop chemoresistance, leading to a poor prognosis. However, the underlying mechanism of circRNAs in HCC chemoresistance remains unclear.
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- The study investigates the role of PD-1 expression in tumor-associated macrophages (TAMs) and its impact on osteosarcoma (OS) progression, particularly in lung metastases.
- Using single-cell RNA sequencing, researchers identified various cell clusters within human OS metastatic lesions, revealing an increase in exhausted T cells and regulatory T cells while noting that T cells in metastases proliferate less than those in primary tumors.
- The findings indicate that the immunosuppressive M2 phenotype of TAMs in OS metastasis hinders their ability to eliminate cancer cells, highlighting the potential of PD-1 inhibitors as a therapeutic approach for OS.
Article Synopsis
- Lung cancer, specifically lung adenocarcinoma (LUAD), has poor prognosis, prompting a study to create an immune-related gene prognostic index (IRGPI) to assess patient outcomes and responses to immune checkpoint inhibitors (ICI).
- By utilizing data from the TCGA database, researchers identified differentially expressed immune-related genes (DEIRGs) and constructed the IRGPI model using Cox regression analyses, grouping patients into high- and low-risk categories for further survival analysis.
- Results indicated that patients with a high-risk IRGPI had a significantly lower overall survival rate and were associated with unfavorable immune characteristics, but interestingly, they may still respond better to ICI treatment.
Objective: Lung adenocarcinoma (LA) is one of the most common malignancies and is responsible for the greatest number of tumor-related deaths. Our research aimed to explore the molecular subtype signatures of LA to clarify the correlation among the immune microenvironment, clinical outcomes, and therapeutic response.
Methods: The LA immune cell marker genes (LICMGs) identified by single-cell RNA sequencing (scRNA-seq) analysis were used to discriminate the molecular subtypes and homologous immune and metabolic traits of GSE72094 LA cases.
Hepatocellular carcinoma (HCC) is a major global public health concern, with approximately 79 million new cases and 75 million HCC-related deaths occurring annually worldwide. Among the drugs, cisplatin (DDP) is considered a cornerstone and has been shown to significantly inhibit cancer progression. However, the mechanism underlying DDP-resistance in HCC remains unclear.
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- Acetaminophen overdose is a leading cause of drug-induced liver injuries, primarily causing oxidative damage and triggering autophagy in liver cells.
- This study found that Echinacea purpurea polysaccharide (EPPS) can protect against liver damage caused by acetaminophen overdose in mice by reducing inflammation, oxidative stress, and cell death.
- EPPS works mainly through a process called Parkin-dependent autophagy, which suggests it could be a potential new treatment for acetaminophen-induced liver injury.
Background: Hepatocellular carcinoma (HCC) is the leading cause of cancer death. Kinesin family member 2C () has been shown as oncogene in a variety of tumors. However, its role in HCC remains unclear.
View Article and Find Full Text PDFThe aim of this study was to select qualified patients with hepatocellular carcinoma (HCC) who underwent right hepatectomy (RH) intraoperative indocyanine green retention test at 15 min (ICG-R15) of the left hemiliver, which prevents severe posthepatectomy liver failure (PHLF). Twenty HCC patients who were preoperatively planned to undergo RH were enrolled. Intraoperative ICG-R15 of left hemiliver was measured after the right Glissonean pedicle was completely blocked.
View Article and Find Full Text PDFHepatitis B virus infection is associated with liver disease, including cancers. In this study, we assessed the power of sex-determining region Y (SRY)-related high-mobility group (HMG)-box 4() gene to predict the clinical course of hepatocellular carcinoma (HCC). To evaluate the differential expression of and its diagnostic and prognostic potential in HCC, we analyzed the GSE14520 dataset.
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- Dietary exposure to aflatoxin B1 (AFB1) induces mutations in the TP53 gene that are linked to liver cancer (HCC), especially in those also infected with hepatitis B virus (HBV).
- A genome-wide association study identified SNPs associated with the TP53 R249S mutation, revealing that this mutation correlates with higher TP53 expression in HCC patients.
- The study found significant links between specific SNPs (ADAMTS18, WDR49, and SLC8A3) and the R249S mutation, with variations in the ADAMTS18 gene expression observed between tumor and non-tumor tissues in HCC patients. *
Background: Hepatitis B virus (HBV) infection and dietary aflatoxin exposure are two major and synergistic carcinogenic factors of hepatocellular carcinoma (HCC) in southern China. Mutation of the gene at codon 249 (TP53 249Ser) is recognized as a fingerprint of aflatoxin B1 (AFB1) exposure.
Methods: A total of 485 HCC patients positive for serum hepatitis B surface antigen were enrolled.
Hepatocellular carcinoma (HCC) is a lethal malignancy worldwide. HCC has traits of late diagnosis and high recurrence. This study explored potential diagnosis and prognosis significance of phospholipase C epsilon 1 (PLCE1) in HCC.
View Article and Find Full Text PDFThe goal of our current study is to assess the immunohistochemical of p53, p21, nm23, and VEGF expression in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) prognosis after hepatectomy, as well as the prospective molecular mechanisms of prognostic indicator. There were 419 HBV-related HCC patients who were from southern China of Guangxi province and were used to evaluate the immunohistochemical expression for these biomarkers in prognosis. A genome-wide expression microarray dataset of HBV-related HCC were obtained from GSE14520.
View Article and Find Full Text PDFThe purpose of this investigation was to explore the prognostic value of phospholipase C delta (PLCD) genes in early stage pancreatic ductal adenocarcinoma (PDAC) and its potential molecular mechanisms. The prognostic value of PLCD genes in early stage PDAC was assessed using the Kaplan-Meier method and multivariate Cox proportional hazards regression model. Genome-wide correlation analysis was performed on PLCD3 to identify the highly correlated genes in the transcriptome.
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- The study investigates biomarkers and pathways linked to hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV), using datasets from GSE14520 and The Cancer Genome Atlas.
- Differentially expressed genes (DEGs) were identified, leading to the discovery of pathways associated with HCC, including the cell cycle and p53 pathways, with 11 hub DEGs highlighted through weighted gene co-expression network analysis (WGCNA).
- Certain DEGs were linked to poor clinical outcomes and could serve as diagnostic and prognostic biomarkers for HBV-related HCC, potentially improving understanding of hepatocarcinogenesis.
Article Synopsis
- Hepatitis B virus infection is linked to liver diseases and liver tumors, and this study examines the relationship between Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC).
- The research utilized the GSE14520 dataset for diagnostic and prognostic analysis, created a nomogram to estimate survival rates for HCC, and conducted gene set enrichment analysis.
- Findings indicate that HLA complex could serve as a diagnostic biomarker, with specific elements showing significant prognostic value for overall and recurrence-free survival in HCC patients.
Article Synopsis
- The study aimed to explore how Kinesin-4 family genes mRNA expression, particularly KIF21A, affects the survival prognosis of early-stage pancreatic ductal adenocarcinoma (PDAC) patients after surgery.
- The researchers used various statistical analyses, including Kaplan-Meier and Cox regression, to establish a connection between KIF21A expression levels and patient survival outcomes, ultimately creating a nomogram for personalized prognosis.
- Findings showed that high expression of KIF21A is associated with shorter overall survival, suggesting it as a potential biomarker for predicting outcomes in early-stage PDAC patients post-surgery.
Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training cohort containing 212 hepatitis B virus‑infected HCC patients from the Gene Expression Omnibus database, and data from The Cancer Genome Atlas as a validation cohort containing 370 HCC patients, were used to analyze the diagnostic and prognostic significance for HCC.
View Article and Find Full Text PDFThe present study aimed to determine the clinical significance and potential molecular mechanisms of C‑C motif chemokine receptor (CCR) genes in patients with early‑stage pancreatic ductal adenocarcinoma (PDAC). The transcriptomic, survival and clinical data of 112 patients with early‑stage PDAC who underwent pancreaticoduodenectomy were obtained from The Cancer Genome Atlas. The prognostic values of the CCR genes involved in early‑stage PDAC were evaluated using Kaplan‑Meier analysis and the multivariate Cox proportional risk regression model, and the potential molecular mechanisms were determined using bioinformatics tools.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is one of the leading causes of tumor‑related mortalities worldwide. Long noncoding RNAs have been reported to be associated with tumor initiation, progression and prognosis. The present study aimed to explore the association between long noncoding RNA LINC00668 and its co‑expression correlated protein‑coding genes (PCGs) in HCC.
View Article and Find Full Text PDFATPase family AAA domain-containing protein 3 () is a mitochondrial membrane-bound ATPase that is involved in a number of cellular processes and is linked with the progression of various types of malignancies. In primates, the gene cluster contains and . The association between gene cluster expression and hepatocellular carcinoma (HCC) remains unknown.
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- The study focused on the WNT gene family's role in diagnosing and predicting outcomes for patients with hepatocellular carcinoma (HCC) linked to hepatitis B virus (HBV) infection.
- Researchers analyzed patient clinical data and gene expression from various databases, using methods like ROC curve analysis for diagnostics and survival analysis to assess overall and recurrence-free survival rates related to WNT gene expression.
- Findings highlighted that WNT2 could be a valuable diagnostic biomarker, while WNT1 showed significant links to overall and recurrence-free survival, indicating its potential as a prognostic biomarker for HCC.
Article Synopsis
- The study aims to identify a competing endogenous RNA (ceRNA) network by analyzing dysregulated RNAs in hepatocellular carcinoma (HCC) using data from The Cancer Genome Atlas (TCGA).
- The research involved examining RNA sequencing data to discover differentially expressed genes (DEGs), microRNAs, and long non-coding RNAs, ultimately identifying key dysregulated RNAs that contribute to a prognostic signature for overall survival (OS) in HCC patients.
- The findings suggest that the constructed ceRNA network and identified prognostic signature serve as independent indicators for HCC patient survival, with significant enrichment in biological processes related to the cell cycle and cell proliferation.