Physicochemical characteristics and metabolite composition of fish sauce made from large yellow croaker roe enzymatic hydrolysates based on three fermentation temperatures.

Large yellow croaker roes were used to make fish sauce using enzymolysis method, and the impact of different fermentation temperatures (25, 32 and 40 °C) on the physicochemical characteristics and metabolite composition was revealed. Results indicated that compared with 25 and 32 °C, the higher contents of total acidity, amino nitrogen, total soluble nitrogen, and the deepening of the nonenzymatic browning degree of fish sauce fermented at 40 °C were obtained. The total volatile basic nitrogen content at 40 °C was lower than 32 °C.

Targeting mitochondrial function as a potential therapeutic approach for allergic asthma.

Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, excessive mucus secretion, and airway remodeling, with increasing mortality and incidence globally. The pathogenesis of allergic asthma is influenced by various factors including genetics, environment, and immune responses, making it complex and diverse. Recent studies have found that various cellular functions of mitochondria such as calcium regulation, adenosine triphosphate production, changes in redox potential, and free radical scavenging, are involved in regulating the pathogenesis of asthma.

Sex-dependent modulation of T and NK cells and gut microbiome by low sodium diet in patients with primary aldosteronism.

Background: High dietary sodium intake is a major cardiovascular risk factor and adversely affects blood pressure control. Patients with primary aldosteronism (PA) are at increased cardiovascular risk, even after medical treatment, and high dietary sodium intake is common in these patients. Here, we analyze the impact of a moderate dietary sodium restriction on microbiome composition and immunophenotype in patients with PA.

Enhanced Fermentation of Pu-Erh Tea with : Quality and Microbial Community Analysis.

Post-fermented Pu-erh tea (PFPT) is a microbial fermented tea characterized by unique sensory attributes and multiple health benefits. is the dominant fungus involved in the fermentation process and plays a significant role in imparting the distinct characteristics of PFPT. To investigate the role of in the fermentation of Pu-erh tea, this study inoculated unsterilized sun-dried green tea with isolated from Pu-erh tea to enhance the fermentation process.

Correction: Zheng et al. Fabrication of Co-Assembly from Berberine and Tannic Acid for Multidrug-Resistant Bacteria Infection Treatment. 2023, , 1782.

In the original publication [...

Genome-Wide Characterization of CCoAOMT Gene Family and Identification of StCCoAOMT Genes Involved in Anthocyanin Biosynthesis.

Background: The caffeoyl-CoA-O methyltransferase (CCoAOMT) family plays essential roles in the methylation of various secondary metabolites, including anthocyanins. Despite the wide identification of the CCoAOMT family in plants, the characterization and function of CCoAOMT protein members in remain poorly understood.

Methods And Results: In this study, a total of 12 StCCoAOMT members were identified in the genome of using the Blastp and HMM search and were unevenly located on eight chromosomes.

Preliminary exploration of the musk biosynthetic mechanism by transcriptomic sequencing in muskrats.

Musk, secreted by adult male forest musk deer, is a kind of precious Chinese traditional medicine for treating cardiovascular, cerebrovascular and neurogenic diseases. However, a lack of knowledge on musk biosynthetic mechanism and limited musk deer population have seriously hindered the development of the musk industry. Fortunately, given that muskrat musk has similar constituents and pharmacological action with deer musk, muskrat is an ideal model animal for exploring musk biosynthetic mechanism.

CoFe Hydroxide Nanospheres for Enhanced Alkaline Water Splitting and Seawater Oxidation:Anion Doping Effects of Fluorine and Carbonate.

Green hydrogen production can be achieved through electrolysis of fresh water or the use of renewable energy to electrolyze seawater. However, due to the low activity and poor stability of oxygen evolution reaction catalysts, direct electrolysis of alkaline seawater faces significant challenges. Herein, The catalyst F-CoFe(OH)-CO/NF with three-dimensional nanosphere structure was prepared, The introduction of CO into the intermediate layer of CoFe hydroxide improves the corrosion resistance of alkaline electrolyte and the doping of F is to design three-dimensional layered nanostructures, increase the active site, and accelerate the diffusion of the electrolyte.

Andrographolide prevents renal fibrosis via decelerating lipotoxicity-mediated premature senescence of tubular epithelial cells.

Excessive lipid accumulation often occurs in the early stage of chronic kidney disease (CKD) which is prone to induce oxidative stress and mitochondrial damage, promoting the progression of kidney fibrosis. Andrographolide (AP), a multifunctional natural terpenoids derived from Andrographis paniculate, has been suggested to play beneficial roles in metabolic disorders-associated disease. Here, we reported that AP effectively counteracts tubule injury and interstitial fibrosis in mice fed with a long-term high-fat diet (HFD).

Superhydrophobic, Multifunctional, and Mechanically Durable Carbon Aerogel Composites for High-Performance Underwater Piezoresistive Sensing.

Carbon aerogel piezoresistive sensors (CAPSs), owing to their good thermal stability, self-constructed conductive network, and fast response to pressure, have attracted extensive attention in the field of flexible and wearable electronics in recent years. However, it is still a great challenge for CAPSs to monitor subtle deformations and achieve high-performance underwater piezoresistive sensing. Herein, a superhydrophobic and electrically conductive carbon aerogel composite (CAC) was fabricated by the combination of fluorination of carbon aerogels and decoration of fluorinated halloysite nanotubes (HNTs).

Use of UMFNPs/Ce6@MBs in multimodal imaging-guided sono-photodynamic combination therapy for hepatocellular carcinoma.

Early diagnosis of liver cancer and appropriate treatment options are critical for obtaining a good prognosis. However, due to technical limitations, it is difficult to make an early and accurate diagnosis of liver cancer, and the traditional imaging model is relatively simple. Therefore, we synthesized multifunctional diagnostic/therapeutic nanoparticles, UMFNPs/Ce6@MBs, loaded with ultra-small manganese ferrite nanoparticles (UMFNPs) and chlorin e6 (Ce6).

Nebulization of Hypoxic hUCMSC-EVs Attenuates Airway Epithelial Barrier Defects in Chronic Asthma Mice by Transferring CAV-1.

Background: Nebulization of hypoxic human umbilical cord mesenchymal stem cell-derived extracellular vesicles (Hypo-EVs) can suppress airway inflammation and remodeling in a chronic asthmatic mouse; however, the exact mechanism remains unclear. Recently, airway epithelial barrier defects have been regarded as crucial therapeutic targets in asthma. The aim of this study was to investigate whether and how Hypo-EVs protect against the disruption of the airway epithelial barrier under asthmatic conditions.

Predicting Functional Outcomes of Endovascular Thrombectomy in Acute Ischemic Stroke Using a Clinical-Radiomics Nomogram.

Background: Endovascular thrombectomy (EVT) is recommended for acute ischemic stroke due to large-vessel occlusion. However, approximately 50% of patients still experience poor outcomes after the procedure. This study aimed to assess whether a nomogram model that integrates computed tomography angiography radiomics features and clinical variables can predict EVT outcomes in patients with acute ischemic stroke.

Caffeic acid-mediated photodynamic multifunctional hyaluronic acid-gallic acid hydrogels with instant and enduring bactericidal potency accelerate bacterial infected wound healing.

The emergence of drug-resistant bacteria poses significant challenges in wound treatment. Antimicrobial photodynamic therapy has emerged as an effective approach to eliminating bacteria by inducing oxidative stress without causing drug resistance. Here, we developed a natural hyaluronic acid (HA)-gallic acid (GA) conjugation-based hydrogel combined with herbal photosensitizer-caffeic acid (CA), which exhibits self-healing ability, shape adaptability, biodegradability, and robust tissue adhesion.

Clinical significance of serum FGF21 levels in diagnosing nonalcoholic fatty liver disease early.

The endogenous FGF21 level is a potential target for diagnosing NAFLD. This study aimed to assess the clinical utility of FGF21 in diagnosing NAFLD and provide new ideas for predicting and preventing NAFLD. A total of 193 patients diagnosed with NAFLD based on diagnostic criteria and 64 healthy individuals were included in the NAFLD and non-NAFLD groups, respectively.

Scalable Electro-Biosynthesis of Ectoine from Greenhouse Gases.

Converting greenhouse gases into valuable products has become a promising approach for achieving a carbon-neutral economy and sustainable development. However, the conversion efficiency depends on the energy yield of the substrate. In this study, we developed an electro-biocatalytic system by integrating electrochemical and microbial processes to upcycle CO into a valuable product (ectoine) using renewable energy.

Synergistically Augmenting Cancer Immunotherapy by Physical Manipulation of Pyroptosis Induction.

Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of inflammasomes and the following inflammatory responses. Recent studies have elucidated the value of pyroptosis induction in cancer treatment.

Influence of fermentation with lactic bacteria on the structure, functional properties and antioxidant activity of flaxseed gum.

Flaxseed meal is a by-product of flaxseed oil extraction. In this research, lactic acid bacteria suitable for modification of flaxseed gum were screened based on cellulase activity and the extraction rate of flaxseed gum. The enzyme-weight method was employed to extract flaxseed gum (SDF).

subsp. 1.0207 Exopolysaccharides Attenuate Hydrogen Peroxide-Induced Oxidative Stress Damage in IPEC-J2 Cells through the Keap1/Nrf2 Pathway.

subsp. () is one of the most commonly employed in the food industry. Exopolysaccharides (EPS) of , which are known to exhibit probiotic properties, are secondary metabolites produced during the growth of .

Liquid crystal phase behavior of oxalated cellulose nanocrystal and optical films with controllable structural color induced by centripetal force.

Cellulose nanocrystal (CNC) is a sustainable bio-nanomaterial. The distinctive left-handed polarization properties render cellulose nanocrystal a promising candidate for optical film. Due to eco-friendliness, reliability, mildness and simplicity, the oxalate hydrolysis method stands out among various preparation methods for CNC.