Tunable Memory Performances of Hyperbranched Polyimides Functionalized with Metal-Porphyrins.

With the rapid advancement of information technology, the need to achieve ultra-high-density data storage has become a pressing necessity. This study synthesized three hyperbranched polyimides (HBPI-TAPP, HBPI-(Zn)TAPP, and HBPI-(Cu)TAPP) by polymerizing 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP), which features a cavity for metal ion coordination, with 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), to systematically investigate the effect of metal ion species on storage performance. According to the results, memory devices based on HBPI-(Zn)TAPP exhibit volatile SRAM (static random-access memory) characteristics, whereas devices employing HBPI-TAPP and HBPI-(Cu)TAPP demonstrate non-volatile WORM (write-once, read-many) characteristics.

Graphene Supported NiFe-LDH and PbO Catalysts Prepared by Plasma Process for Oxygen Evolution Reaction.

The development of efficient catalysts for water electrolysis is crucial for advancing the low-carbon transition and addressing the energy crisis. This work involves the fabrication of graphene-based catalysts for the oxygen evolution reaction (OER) by integrating NiFe-LDH and PbO onto graphene using plasma treatment. The plasma process takes only 30 min.

Prediction Models for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis.

Background: Stroke is one of the most serious illnesses worldwide and is the primary cause of acquired disability among adults. Post-stroke cognitive impairment (PSCI) is a complication of stroke that significantly impacts patients' daily activities and social functions. Therefore, developing a risk prediction model for PSCI is essential for identifying and preventing disease progression.

Leptin Receptor Deficiency-Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome.

Purpose: This study investigated the impact of hyperglycemia in type 2 diabetes mellitus (T2DM) on the circadian rhythms and function of lacrimal glands (LGs) in contributing to dry eye syndrome. We assessed the effects of hyperglycemia on circadian gene expression, immune cell recruitment, neural activity, and metabolic pathways, and evaluated the effectiveness of insulin in restoring normal LG function.

Methods: Using a T2DM mouse model (db/db mice), circadian transcriptomic changes in LGs were analyzed through RNA sequencing over a 24-hour period.

Insight into the Origin of Second Harmonic Generation and Rational Design in the Metal Halide Borates.

Metal halide borates are promising candidates for high-performance nonlinear optical (NLO) applications, yet the origins of their second harmonic generation (SHG) properties remain unclear. Using atom response theory combined with density functional theory calculations, this study investigates why halogen substitution leads to distinctly different SHG responses in halide monoborates (PbBOX) versus halide pentaborates (PbBOX). We find that the SHG origins vary between these two families due to differences in the strength of the Pb-X interactions.

Preparation, characterization, and anticancer effect of Capsaicin-functionalized selenium nanoparticles.

Introduction: Selenium nanoparticles (SeNPs) are recently emerging as promising anticancer agents because of their high bioavailability, low toxicity and remarkable anticancer activities. However, the application of SeNPs in anticancer has been limited due to instability. Herein, Capsaicin (Cap), a natural active compound found in chili peppers with favorable anticancer activity, was modified with SeNPs to prepare Cap-decorated SeNPs (Cap@SeNPs), and the antiproliferative effect and mechanism of Cap@SeNPs in HepG2 were investigated.

Microalgae-Derived Peptides: Exploring Bioactivities and Functional Food Innovations.

A variety of bioactive peptides with unique and diverse structures could be found in microalgae with various bioactivities including antioxidant, antihypertensive, and antibacterial bioactivities. Food products containing microalgae peptides hold significant health and nutrition potential. Peptide liberation through enzymatic and other processes enhanced protein extraction, and some animal studies were conducted to verify their health-promoting effects.

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl Channel.

Mechanisms of anion permeation within ion channels and nanopores remain poorly understood. Recent cryo-electron microscopy structures of the human bestrophin 1 Cl channel (hBest1) provide an opportunity to evaluate ion interactions predicted by molecular dynamics (MD) simulations against experimental observations. Here, we implement the fully polarizable force field AMOEBA in MD simulations on different conformations of hBest1.

Prominent efficacy and good safety of sequential CD19 and CD22 CAR-T therapy in relapsed/refractory adult B-cell acute lymphoblastic leukemia.

Background: Sequential CD19 and CD22 chimeric antigen receptor (CAR)-T cell therapy offers a promising approach to antigen-loss relapse in relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL); however, research in adults remains limited.

Methods: This study aimed to evaluate the efficacy and safety of sequential CD19 and CD22 CAR-T cell therapy in adult patients with R/R B-ALL between November 2020 and November 2023 (ChiCTR2100053871). Key endpoints included the adverse event incidence, overall survival (OS), and leukemia-free survival (LFS).

Moisture-based green energy harvesting over 600 hours via photocatalysis-enhanced hydrovoltaic effect.

Harvesting the energy from the interaction between hygroscopic materials and atmospheric water can generate green and clean energy. However, the ion diffusion process of moisture-induced dissociation leads to the disappearance of the ion concentration gradient gradually, and there is still a lack of moisture-based power generation devices with truly continuous operation, especially the duration of the current output still needs to be extended. Here, we propose a design for reconstructing the ion concentration gradient by coupling photocatalytic hydrogen evolution reaction with hydrovoltaic effect, to report a moisture-enabled electric generator (MEG) with continuous current output.

Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.

Best1 and Best2 are two members of the bestrophin family of anion channels critically involved in the prevention of retinal degeneration and maintenance of intraocular pressure, respectively. Here, we solved glutamate- and γ-aminobutyric acid (GABA)-bound Best2 structures, which delineate an intracellular glutamate binding site and an extracellular GABA binding site on Best2, respectively, identified extracellular GABA as a permeable activator of Best2, and elucidated the co-regulation of Best2 by glutamate, GABA and glutamine synthetase in vivo. We further identified multiple small molecules as activators of the bestrophin channels.

Prevalence and risk factors of sarcopenia in patients with stroke: a systematic review and meta-analysis.

Stroke is the second leading cause of death and the third-leading cause of disability in the world. The skeletal muscles play a key role in disability following stroke. Although many studies have reported the prevalence and risk factors of sarcopenia in patients with stroke, the results have not been synthesized.

Effects of Trace Elements and Vitamins on the Synthesis of Steroid Hormones in Follicular Granulosa Cells of Yak.

Yak (), a special breed of cattle on the Qinghai-Tibet Plateau, has low fertility due to nutritional deficiency, especially the trace elements. The steroid hormones estradiol (E2) and progesterone (P4) synthesized by yak follicular granulosa cells (BGCs) are involved in the entire reproductive process. In the present study, we investigated the effects of trace elements and vitamins on yak follicular GCs, including the cellular activity, the synthesis of E2 and P4, and the expression of genes related to steroid hormone synthesis.

[Remediation Effect of Iron-manganese Composite-modified Biochar from Different Biomasses on Cd-contaminated Alkaline Soil].

To investigate the remediation effect of iron-manganese-modified biochar from different biomasses （FM-BC） on Cd-contaminated alkaline soil, FM-BC was prepared using branches of , durian shells, and corn stalks. The characteristics of FM-BC, the adsorption of Cd（Ⅱ） in water, and the available, fraction of Cd in alkaline soil were studied using bath adsorption and soil culture experiments. The results showed that the specific surface area, total pore volume, and oxygen content of FM-BC were significantly improved.

Deformable multi-level feature network applied to nucleus segmentation.

Introduction: The nucleus plays a crucial role in medical diagnosis, and accurate nucleus segmentation is essential for disease assessment. However, existing methods have limitations in handling the diversity of nuclei and differences in staining conditions, restricting their practical application.

Methods: A novel deformable multi-level feature network (DMFNet) is proposed for nucleus segmentation.

Unveiling relationships of human instinctive behaviors and blood pressure in Chinese adults: A network analysis.

Objectives: Human behaviors and blood pressure (BP) are closely intertwined, affecting health. However, few studies have demonstrated their complex relationships. Using network analysis, we aimed to untangle the intricate and potential causal relationships between BP and human instinctive behaviors, identifying potential action points for hypertension prevention and control.

Distinct clinical features of urothelial carcinoma with low-expressing human epidermal growth factor receptor 2 status.

Background: Some urothelial carcinoma patients are ineligible for platinum-based chemotherapy, necessitating exploration of other effective therapeutic strategies. Human epidermal growth factor receptor 2 (HER2) protein overexpression, gene amplification or mutations exist in urothelial carcinoma. Our study is to investigate the correlation of three-tier assessment of HER2 expression with clinical pathological characteristics and prognosis of urothelial carcinoma.

Characterization and Implications of the Regionally Prevalent ST8333 Strains of Serotype 4,[5],12:i: - China, 2017-2023.

What Is Already Known About This Topic?: is a significant foodborne pathogen responsible for millions of infections and thousands of deaths worldwide each year. The increasing prevalence of the ST34 serotype 4,5,12:i:-(. 4,[5],12:i:-) poses a substantial public health threat in China.

The novel β-hairpin antimicrobial peptide D-G(RF)3 demonstrates exceptional antibacterial efficacy.

The clinical application of most natural antimicrobial peptides (AMPs) is hindered by their lack of a synergistic combination of high antibacterial efficacy, low toxicity, and stability, necessitating frequent complex modifications that incur significant labor and economic costs. Therefore, it is imperative to optimize the antibacterial properties of AMPs using some simplified approach. In this study, we designed a library of β-hairpin AMPs with identical β-turn sequences (-D-Pro-Gly-) and varying repetition units (IR, FR, and WK).

AURKA inhibits the decidualization of the eutopic endometrium in endometriosis through NF-κB p65†.

Endometriosis is an estrogen dependent disease, which is related to infertility. Decidualization is a prerequisite for successful implantation of human embryos, and endometriosis affects the occurrence of decidualization. However, the mechanism that affects decidualization in endometriosis is not fully understood.

Femtosecond vortices generated from a self-started Kerr-lens mode-locked Hermite-Gaussian thin-disk oscillator with a defective mirror.

We demonstrate the generation of stable femtosecond vortices from a self-started Kerr-lens mode-locked Yb:YAG thin-disk oscillator. By using a defective mirror inscribed with a fine line, 218-fs Hermite-Gaussian (HG) pulses are delivered directly from the thin-disk oscillator with an average power of 12 W at the repetition rate of 105 MHz and subsequently converted to Laguerre-Gaussian (LG) vortices by a cylindrical-lens mode-converter. The average output power of the Hermite-Gaussian pulses is further improved to 19 W by applying a rectangular aperture.

Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia.

Background: Schizophrenia (SZ) is a severe mental disorder that is marked by hallucinations and cognitive impairments. Ferroptosis is a type of cell death that is associated with iron and lipid peroxidation; it may play a role in SZ etiology. The present study aimed to explore the correlations between ferroptosis-related genes and SZ in three brain regions.

Reprint of: Does two-step infusion improve the pharmacokinetics/pharmacodynamics target attainment of meropenem in critically Ill patients?

The optimal method for administering meropenem remains controversial. This study was conducted to explore the optimal two-step infusion strategy (TIT), and to investigate whether TIT is superior to intermittent infusion therapy (IIT) and prolonged infusion therapy (PIT). A physiologically based pharmacokinetics model for critically ill patients was established and evaluated.