Wearable Devices as Tools for Better Hypertension Management in Elderly Patients.

BACKGROUND Hypertension is a growing global health concern, particularly among the elderly, and is a significant contributor to cardiovascular and cerebrovascular diseases. Managing hypertension in elderly patients is particularly challenging, requiring continuous monitoring and strict adherence to treatment protocols. This study aimed to evaluate the effectiveness of integrated management strategies that utilize wearable devices in enhancing hypertension management for elderly patients.

Knockdown of Impairs Fecundity by Inhibiting Lipid Accumulation and Increasing Glycogen Storage in .

() is a pivotal gene in the lipid synthesis pathway and plays a crucial role in insect energy metabolism. , as one of the major agricultural pests, requires identification of new targets to control or reduce its reproductive capacity for effective locust pest management strategies. In this study, we focused on and identified as a potential target gene with functional significance in lipid metabolism and reproduction based on sequence characteristics analysis and tissue-expression patterns of five genes.

Comprehensive evaluation of twelve kiwifruit (Actinidia) varieties on the winemaking adaptability based on multi-criteria decision-making method.

As one of the deep processing products of kiwifruit, kiwifruit wine (KW) has shown good commercial development prospects. In this paper, the wine-making adaptability and quality characteristics of 12 kiwifruit varieties with three pulp colors were systematically evaluated from the aspects of basic physicochemical, functional and sensory qualities. The results of the study showed that the ratio of sugar to acid of Hongyang wine was 0.

Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation.

Purpose: This study aims to investigate whether zinc ion (Zn) alleviates myocardial ischemia-reperfusion injury (MIRI) through the MAM-associated signaling pathway and to explore its impact on ERS and calcium overload.

Methods: H9C2 cells were cultured in a DMEM supplemented with 10 % fetal bovine serum and 1 % antibiotic solution. A MIRI model was established through simulated ischemia and reoxygenation with Zn treatment in a complete medium.

Analysis of the Flavor Code of Newly Cultivated Excellent Apple Varieties in China Using the Sensomics.

"Rui Yang", "Rui Xue", and "Rui Xiang Hong" are newly cultivated apple varieties with excellent flavor. However, the key aroma-active compounds responsible for its excellent flavor quality were unclear. This study determined the characteristics of aroma compounds among three new apple varieties and their parental species by Sensomics.

Spinal muscular atrophy with progressive myoclonic epilepsy: A case report from China with new variants.

We report a case of a Chinese girl who presented with multiple seizure types of epilepsy, followed by motor and intellectual regression, vision impairment, and cerebral and cerebellar atrophy. She carries an unreported compound heterozygous variant of the ASAH1 gene and is diagnosed with spinal muscular atrophy associated with progressive myoclonic epilepsy (SMA-PME), a disorder in which ceramide accumulation in lysosomes due to a decrease in acid ceramidase activity. This case suggests attention to this rare class of deceases involving both the central and peripheral nervous systems.

Felt stigma as a determinant of health-related quality of life among community-dwelling stroke survivors in China: A cross-sectional study.

Objectives: To assess the role of felt stigma versus enacted stigma in the health-related quality of life of community--dwelling stroke survivors in China.

Materials And Methods: A sample of 189 community--dwelling stroke survivors were investigated with the Stigma Scale for Chronic Illness (SSCI), 12-item Short Form-12 Health Survey (SF-12), modified Barthel index (MBI), Zung Self-Rating Depression Scale (ZSDS), and demographic and disease-related characteristics. Hierarchical multiple regression analysis was used to estimate the influence of felt stigma and enacted stigma on quality of life after controlling for depression, activities of daily living, and patient characteristics.

Advances on the Role of Lung Macrophages in the Pathogenesis of Chronic Obstructive Pulmonary Disease in the Era of Single-Cell Genomics.

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous respiratory disorder characterized by persistent airflow limitation. The diverse pathogenic mechanisms underlying COPD progression remain incompletely understood. Macrophages, serving as the most representative immune cells in the respiratory tract, constitute the first line of innate immune defense and maintain pulmonary immunological homeostasis.

A Randomized Comparison of Bencycloquidium Bromide, Mometasone Furoate, and a Combination for Persistent Allergic Rhinitis.

Background: Moderate to severe persistent allergic rhinitis (AR) poses a substantial socioeconomic burden.

Objectives: We aimed to establish the superiority of bencycloquidium bromide (BCQB) nasal spray and BCQB combined with mometasone furoate nasal spray (MFNS) over MFNS alone in adults with moderate to severe persistent AR.

Methods: In this multicenter, randomized, controlled clinical trial (NCT05038202), adults with moderate to severe persistent AR were randomly assigned to receive BCQB, MFNS, or a combination treatment for 4-week periods.

Cerebral oximetry index indicates delirium or stroke after carotid endarterectomy: An observational study.

Backgrounds: The cerebral oximetry index (CO) uses near-infrared spectroscopy to estimate cerebral autoregulation during cardiac surgery. However, the relationship between intraoperative loss of cerebral autoregulation and postoperative delirium or stroke remains unclear in patients recovering from carotid endarterectomy (CEA).

Methods: Our prospective observational cohort study enrolled patients scheduled for CEA.

Bioinspired adaptive lipid-integrated bilayer coating for enhancing dynamic water retention in hydrogel-based flexible sensors.

While hydrogel-based flexible sensors find extensive applications in fields such as medicine and robotics, their performance can be hindered by the rapid evaporation of water, leading to diminished sensitivity and mechanical durability. Despite the exploration of some effective solutions, such as introducing organic solvents, electrolytes, and elastomer composites, these approaches still suffer from problems including diminished conductivity, interface misalignment, and insufficient protection under dynamic conditions. Inspired by cell membrane structures, we developed an adaptive lipid-integrated bilayer coating (ALIBC) to enhance water retention in hydrogel-based sensors.

RNAi-Mediated Silencing Inhibits Reproduction in .

is a downstream target gene of cellular nutrient and growth factors, oxidative stress responses, and insulin signaling pathways. It play a crucial role in insect growth, development, and reproduction. is a significant agricultural pest; therefore, the identification of novel control targets for its management is of significant importance.

Analysis of cis-regulatory changes underlying phenotype divergence shaped by domestication in pigs.

Background: Cis-regulatory elements (CREs) are regions of DNA that regulate the expression of nearby genes. Changes in these elements can lead to phenotypic variations and adaptations in different populations. However, the regulatory dynamics underlying the local adaptation of traits remain poorly understood in Chinese and Western pigs.

Repairing effect of magnesium oxychloride cement modified by γ-polyglutamic acid and chitosan in osteoporotic bone defect.

Magnesium oxychloride cement (MOC) has the advantage of high early strength. However, it has the defect of poor water resistance. Considering this performance, we use γ-polyglutamic acid (γ-PGA) and chitosan (CS) to modify MOC.

Characteristic roadmap of linker governs the rational design of PROTACs.

Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically degrade proteins responsible for the disease. PROTAC is characterized by its unique heterobifunctional structure, which comprises two functional domains connected by a linker. The linker plays a pivotal role in determining PROTAC's biodegradative efficacy.

A machine learning based radiomics approach for predicting No. 14v station lymph node metastasis in gastric cancer.

Purpose: To evaluate the potential of radiomics approach for predicting No. 14v station lymph node metastasis (14vM) in gastric cancer (GC).

Methods: The contrast enhanced CT (CECT) images with corresponding clinical information of 288 GC patients were retrospectively collected.

Fatty acid synthase 2 knockdown alters the energy allocation strategy between immunity and reproduction during infection by Micrococcus luteus in Locusta migratoria.

Immunity and reproduction are vital functions for the survival and population maintenance of female insects. However, owing to limited resources, these two functions cannot be fulfilled simultaneously, resulting in an energy tradeoff between them. Notably, the mechanisms underlying this immune-reproductive trade-off, in which energy competition likely plays a central role, remain poorly understood.

Recognition of a salivary effector by the TNL protein RCSP promotes effector-triggered immunity and systemic resistance in Nicotiana benthamiana.

Insects secret chemosensory proteins (CSPs) into plant cells as potential effector proteins during feeding. The molecular mechanisms underlying how CSPs activate plant immunity remain largely unknown. We show that CSPs from six distinct insect orders induce dwarfism when overexpressed in Nicotiana benthamiana.

SoftBoMI: a non-invasive wearable body-machine interface for mapping movement of shoulder to commands.

Customized human-machine interfaces for controlling assistive devices are vital in improving the self-help ability of upper limb amputees and tetraplegic patients. Given that most of them possess residual shoulder mobility, using it to generate commands to operate assistive devices can serve as a complementary approach to brain-computer interfaces.We propose a hybrid body-machine interface prototype that integrates soft sensors and an inertial measurement unit.

An Eleven-Year Retrospective Survey of Anaerobic Bloodstream Infection in Adults in a General Hospital.

Objective: During conditions accompanied by the disruption of normal mucosal barriers, anaerobic bacteria, which a part of normal human mucosal microflora, may cause various infections. In this study, clinical features of anaerobic bloodstream infections (BSI) in a general hospital in China were investigated.

Methods: Patients with anaerobic BSI were retrospectively enrolled between 2012 and 2022.

The identification of essential cellular genes is critical for validating drug targets.

Accurately identifying biological targets is crucial for advancing treatment options. Essential genes, vital for cell or organism survival, hold promise as potential drug targets in disease treatment. Although many studies have sought to identify essential genes as therapeutic targets in medicine and bioinformatics, systematic reviews on their relationship with drug targets are relatively rare.

Ultrasound and its coupled oak blocks treatment based on absorbed energy density for comprehensive insight and scale-up consideration of phenolic and astringency profiles in red wines.

Ultrasound and ultrasound-coupled oak blocks techniques on the phenolic and astringency profiles of Petit Verdot wines were discussed in this study. The relationship between techniques at varying absorbed energy density (AED) gradients and astringency was revealed, elucidating potential molecular mechanisms regarding compound interactions. Ultrasound was found to promote phenolics degradation and condensed tannins maturation, while oak blocks improved ellagitannins release into wines, facilitating polycondensation reactions to form larger complexes.