Development and validation of a nomogram for predicting visceral pleural invasion in patients with early-stage non-small cell lung cancer.

Background: Visceral pleural invasion (VPI) is associated with a poor outcome in early-stage non-small cell lung cancer (NSCLC). Preoperative prediction of VPI could have an impact on surgical planning. The aim of this study was to establish a nomogram model based on computed tomography (CT) features to predict VPI in early-stage NSCLC.

Embracing plant plasticity or robustness as a means of ensuring food security.

The dual challenges of global population explosion and environmental deterioration represent major hurdles for 21 Century agriculture culminating in an unprecedented demand for food security. In this Review, we revisit historical concepts of plasticity and canalization before integrating them with contemporary studies of genotype-environment interactions (G×E) that are currently being carried out at the genome-wide level. In doing so we address both fundamental questions regarding G×E and potential strategies to best secure yields in both current and future climate scenarios.

Association of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study.

Objectives: To explore whether the triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with the trajectories of depressive symptoms.

Methods: In this longitudinal study, 4215 participants aged 45 years and older were recruited from the China Health and Retirement Longitudinal Study from 2011 to 2018. The trajectories of depressive symptoms, measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), were identified using group-based trajectory modeling.

Reconfigurable Phototransistors Driven by Gate-Dependent Carrier Modulation in WSe/TaNiSe van der Waals Heterojunctions.

Reconfigurable field-effect transistors (RFETs) offer notable benefits on electronic and optoelectronic logic circuits, surpassing the integration, flexibility, and cost-efficiency of conventional complementary metal-oxide semiconductor transistors. The low on/off current ratio of these transistors remains a considerable impediment in the practical application of RFETs. To overcome these limitations, a van der Waals heterojunction (vdWH) transistor composed of WSe/TaNiSe has been proposed.

The removal of high Se(IV) and Cd(II) concentrations in sulfur autotrophic reactor based on the "hibernation-like microbial survival strategy".

The removal of selenite (Se(IV)) and cadmium (Cd(II)) from low-carbon wastewater presents significant challenges. However, the addition of external organic carbon sources is limited in application due to the high cost and potential for secondary pollution. This study introduced a "hibernation-like microbial survival strategy", enabling efficient removal of Se(IV) and Cd(II) in sulfur autotrophic reactor, with S acting as the electron donor.

FGF20 Secreted From Dermal Papilla Cells Regulate the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine-Wool Sheep.

Wool traits determine the market value of fine-wool sheep, and wool fibre-breaking elongation (fibres can be stretched or elongated before they break) is one of the important wool traits. The interaction between hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) determines hair follicle development in fine wool sheep, thereby directly influencing wool traits. A genome-wide association study based on pre-sequencing data identified FGF20, which was significantly associated with wool fibre-breaking elongation.

Cervical intraepithelial neoplasia and cervical cancer in Hunan Province, China, 2020-2023.

Objective: To describe the incidence and distribution of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC) for rural women aged 35-64 in Hunan Province, China, 2020-2023.

Methods: Data were from the Hunan Provincial Cervical Cancer Screening Program in Rural Areas. Most rural women aged 35-64 in Hunan Province attend the program.

Study on the mechanism of regulating micromolar Fe utilization and promoting denitrification by guanosine monophosphate (GMP) based multi-signal functional material Hematin@Fe/GMP.

A novel multi-signal functional material consisting of Hematin, Fe, and guanosine monophosphate (GMP) was successfully constructed (Hematin@Fe/GMP) to enhance denitrification efficiency based on the signal network regulation of electron transfer, micromolar Fe utilization, and microbial community. Hematin@Fe/GMP enhanced nitrate reduction rate by 2.33-fold with a 9.

Construction of spontaneous built-in electric field on heterointerface furnishing continuous efficient adsorption-directional migration-conversion of polysulfides.

Integrating sulfur with efficient electrocatalysts remains a pressing need in lithium-sulfur (Li-S) batteries for modulating the sluggish conversion kinetics and restricting the shuttle behavior of lithium polysulfides (LiPSs). Herein, a compact p-type FeO and n-type MoS heterostructure embedded on nitrogen-doped porous carbon (FeO-MoS-NPC-0.5) is meticulously constructed as dual-functional hosts that can facilitate continuous catalytic conversion of LiPSs.

Transcriptome and metabolome revealed the effects of hypoxic environment on ovarian development of Tibetan sheep.

Many studies on the adaptability of Tibetan sheep to hypoxia have been reported, but little attention has been paid to the reproduction of Tibetan sheep living at an altitude of more than 4000 m. In this study, the ovaries of Alpine Merino sheep (AM) living in middle-high altitude areas (2500 m) and the ovaries of Gangba Tibetan sheep (GB) and Huoba Tibetan sheep (HB) living in ultra-high altitude areas (4400 m or more) were collected. Through morphological, transcriptomics and metabolomics, the effects of ultra-high altitude areas on Tibetan sheep ovarian development and the molecular mechanism of sheep's adaptability to ultra-high altitude environment were explored.

CT-based delta-radiomics for predicting pathological response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a multicenter study.

Background: The study aimed to investigate the predictive value of delta-radiomics derived from computed tomography (CT) for pathological complete response (pCR) to neoadjuvant immunochemotherapy (NICT) among patients with esophageal squamous cell carcinoma (ESCC), helping clinicians determine whether to modify the neoadjuvant treatment strategy, proceed to surgery, or forgo surgery altogether.

Methods: A total of 140 ESCC patients from two institutions (Database 1 = 93; Database 2 = 47) who underwent NICT and surgery were retrospectively included in the study. The training set consisted of patients from Database 1, while the testing set included patients from Database 2.

A copper(II)-based metal-organic framework: electrochemical sensing of Cd(II) and Pb(II) and adsorption of organic dyes.

A new inorganic-organic hybrid complex, namely [CuL(DMF)]·HO (Cu-L), has been synthesized using a sulfur-rich ligand, 3,3',3''-(1,3,5-triazine-2,4,6-triyltrisulfanediyl)tripropanoic acid (HL) and metal cations under hydrothermal conditions. The metal atoms are interconnected to form a paddle-wheel-like structure, which is ultimately linked to the ligands to create a three-dimensional architecture. Cu-L, employed to fabricate an electrochemical sensor denoted as Cu-L@GCE (glassy carbon electrode), is capable of simultaneously detecting Cd and Pb at approximately -0.

Intraocular complement activation is independent of systemic complement activation and is related to macular vascular remodelling in retinal vein occlusion.

Background: Retinal vein occlusion (RVO) is a major cause of vision loss. The pathogenesis remains poorly defined although inflammation is known to play a critical role. In this study, we investigated the levels of complement proteins in the aqueous humour and plasma of RVO participants and the relationship between complement levels and retinal pathologies.

Generation, Characterization, and Preclinical Studies of a Novel NKG2A-Targeted Antibody BRY805 for Cancer Immunotherapy.

Immuno-oncology has revolutionized cancer treatment, with NKG2A emerging as a novel target for immunotherapy. The blockade of NKG2A using the immune checkpoint inhibitor (ICI) monalizumab has been shown to enhance the responses of both NK cells and CD8+ T cells. However, monalizumab has demonstrated limited efficacy in in vitro cytotoxic assays and clinical trials.

CuBr-mediated surface-initiated controlled radical polymerization in air.

Herein, we present a straightforward CuBr-mediated surface-initiated controlled radical polymerization (SI-CRP) method for fabricating polymer brushes using microliter volumes of reaction solution in air and at room temperature. The key advantage of this method is its ability to rapidly grow polymer brushes with oxygen tolerance, driven by the controlled disproportionation of Cu into Cu and Cu by CuBr and ligand. We demonstrate the successful preparation of homo-, block, patterned, and wafer-scale polymer brushes.

Isolation and identification of patient-derived liver cancer stem cells and development of personalized treatment strategies.

Background: Liver cancer stem cells (LCSCs) are thought to drive the metastasis and recurrence, however, the heterogeneity of molecular markers of LCSCs has hindered the development of effective methods to isolate them.

Methods: This study introduced an effective approach to isolate and culture LCSCs from human primary liver cancer (HPLC), leveraging mouse embryonic fibroblasts (MEFs) as feeder cells in conjunction with using defined medium. Isolated LCSCs were further characterized by multiple approaches.

Amorphous Cu/Fe nanoparticles with tandem intracellular and extracellular electron capacity for enhancing denitrification performance and recovery of co-contaminant suppressed denitrification.

In this study, a functionally stable insoluble Cu/Fe nanoparticles (Cu/Fe NPs) were synthesized and applied denitrification with different contaminants. The results showed that 50 mg/L Cu/Fe NPs increased NO-N reduction rate up to 14.3 mg/(L·h) about 3 folds compared with the control system (4.

Reparative homing of bone mesenchymal stem cells induced by iMSCs via the SDF-1/CXCR4 axis for articular cartilage defect restoration.

Background: The intrinsic healing ability of articular cartilage is poor after injury or illness, and untreated injury could lead to cartilage degeneration and ultimately osteoarthritis. iMSCs are derived from embryonic induced pluripotent stem cells and have strong therapeutic capabilities in the repair of cartilage defects, while the mechanism of action is unclear. The aim of this study is to clarify the repair mode of iMSCs on cartilage defects in rat knee joints, elucidate the chemotactic effect of iMSCs on autologous BMSCs in rats, and provide a basis for the treatment of cartilage defects and endogenous regeneration with iMSCs.

Generation of Functioning Platelets from Mature Megakaryocytes Derived from CD34 Umbilical Cord Blood Cells.

Clinically patients with thrombocytopenia are in urgent need of platelet transfusion, thus it is necessary to produce the platelets in large scale in vitro to meet the clinical needs. In this study, we developed efficient protocol to generate functioning platelets by differentiating umbilical cord blood (CB)-derived CD34 cells into mature megakaryocytes. Under our condition, up to 85% of mature megakaryocytes were generated from CB-derived CD34 cells, and over 75% CD42bCD62p platelets were produced.

A nomogram for predicting invasiveness of lung adenocarcinoma manifesting as ground-glass nodules based on follow-up CT imaging.

Background: Different pathological stages of lung adenocarcinoma require different surgical strategies and have varying prognoses. Predicting their invasiveness is clinically important. This study aims to develop a nomogram to predict the invasiveness of lung adenocarcinoma manifesting as ground-glass nodules (GGNs) based on follow-up computed tomography (CT) imaging.