Publications by authors named "TingTing Gong"
Background: Ovarian cancer (OC) is a heterogeneous malignancy with multiple histological subtypes, showing global variability in incidence. Temporal changes in diagnostic criteria and risk factors might influence the incidence and distribution of OC and its subtypes.
Methods: This study analyzed incidence patterns (2013-2017) and trends (1988-1992 to 2013-2017) of OC and its subtypes across 65 and 40 countries, respectively.
Postoperative cognitive dysfunction (POCD) is common in the aged population and associated with poor clinical outcomes. Irisin, an endogenous molecule that mediates the beneficial effects of exercise, has shown neuroprotective potential in several models of neurological diseases. Here we show that preoperative serum level of irisin is reduced in dementia patients over the age of 70.
View Article and Find Full Text PDFThe present study aims to summarize the current biomarker landscape in gynecological cancers (GCs) and incorporate bioinformatics analysis to highlight specific biological processes. The literature was retrieved from PubMed, Web of Science, Embase, Scopus, Ovid Medline, and Cochrane Library. The final search was conducted on December 7, 2022.
View Article and Find Full Text PDFDisinfection byproducts (DBPs) in swimming pool water are a significant public health concern. The formation of aromatic halogenated DBPs in swimming pool water has not been clarified previously. In this study, the occurrence of aromatic halogenated DBPs in swimming pool water was examined, and it was found that halohydroxybenzoic acids (HBAs) and halobenzoquinones (HBQs) were the most dominant aromatic halogenated DBPs in swimming pool water that were continuously formed.
View Article and Find Full Text PDFBackground: Numerous prospective cohort studies have investigated the influence of dietary patterns on the risks of various cancers, although the findings differed.
Objectives: To evaluate the associations of dietary patterns with risks of various cancers and assess the strength and validity of the evidence.
Methods: Relevant articles were retrieved from the PubMed, EMBASE, Web of Science, and Cochrane library databases from inception to February 22, 2024.
Purpose: Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.
Methods: The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival.
β-Lactoglobulin (β-Lg) is a prevalent allergenic protein found in most dairy products, which poses great food safety risks for individuals with allergies, especially for infants. Sensitive and effective detection methods for such allergens are essential to reduce the risk of allergies in daily life. Herein, a fluorescent aptamer bioassay based on a dual and cyclic bidirectional strand displacement means is developed for the sensitive detection of β-Lg in infant rice porridge and milk.
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- Environmental pollution, specifically heavy metals, may negatively impact the prognosis of advanced high-grade serous ovarian cancer (HGSOC), but current evidence is limited.
- A study involving 159 deceased HGSOC patients and 159 matched living patients analyzed urinary levels of five heavy metals—arsenic, cadmium, chromium, mercury, and lead—using statistical models to determine associations with overall survival (OS).
- The results showed significant links between high levels of arsenic, cadmium, mercury, and lead in urine and poorer OS, with lead being the most influential in negatively affecting survival, indicating a need for further research.
Article Synopsis
- - The study investigates the link between adverse pregnancy outcomes and cancer risk in mothers and their children, highlighting a growing concern about these health issues.
- - A systematic review of various databases identified 129 meta-analyses, finding significant associations between factors like birth weight and cancers such as breast and leukemia, with moderate certainty in the evidence.
- - The authors conclude that while there are promising connections between certain adverse pregnancy outcomes and cancer risks, further research is necessary to strengthen these associations and address potential biases.
Article Synopsis
- Meta-analyses have shown mixed results regarding the relationship between whole blood cell count-derived indexes (NLR, PLR, LMR) and cancer prognosis, highlighting the need for a clearer understanding of the evidence quality.* ! -
- The review analyzed 694 associations from 224 articles, revealing that 97.8% of these studies were rated as moderate to high quality based on AMSTAR criteria.* ! -
- Although there were four associations with strong evidence, many others were only suggestive, indicating a need for further research to clarify these relationships and determine causality.* !
Background: There is currently a lack of comprehensive evidence regarding the correlation between Alternate Mediterranean Diet (AMED) and the survival of patients with ovarian cancer (OC). This prospective cohort study first assessed the association of AMED, not only pre-diagnosis and post-diagnosis but also the change from pre-diagnosis to post-diagnosis with OC survival.
Methods: A total of 560 OC patients were included in the study, and their dietary intake was assessed using a reliable 111-item food frequency questionnaire.
Article Synopsis
- The Magnetically Controlled Capsule Endoscopy (MCCE) struggles with limited image capture, leading to fragmented visuals and challenges in finding specific areas of interest in the digestive tract.
- A new method called S2P-Matching is introduced to enhance image stitching by simulating how the capsule camera operates, allowing for better analysis of gastrointestinal conditions.
- This approach utilizes advanced deep learning techniques to improve the accuracy of matching MCCE images, yielding significant improvements in identifying correct matches and overall success rate, which could lead to greater use of MCCE for gastrointestinal examinations.
Background: Ambient air pollution might serve as a prognostic factor for ovarian cancer (OC) survival, yet the relationships between plant-based diet indices (PDIs) and OC survival remain unclear. We aimed to investigate the associations of comprehensive air pollution and PDIs with OC survival and explored the effects of air pollution-diet interactions.
Methods: The present study encompassed 658 patients diagnosed with OC.
Article Synopsis
- Neuromodulation treatments, like special brain stimulation methods, are being tested to help people with post-traumatic stress disorder (PTSD).
- In a study with 981 patients, four treatments showed they could lower PTSD symptoms right after treatment, but not much improvement was seen afterward.
- There were no big differences between the real treatments and fake ones, but some methods also helped with depression and anxiety symptoms during and after treatment.
Article Synopsis
- - The study investigated the links between diet quality, as measured by the Healthy Eating Index-2020 (HEI-2020), and survival rates in ovarian cancer patients over a follow-up period until February 2023.
- - It involved 1082 ovarian cancer patients aged 18-79, assessing their dietary habits before and after their diagnosis using a validated food questionnaire.
- - Results indicated that higher diet quality scores led to better overall survival rates, while a decline in diet quality after diagnosis was linked to worse survival outcomes.
Enzyme-triggered oral colon-specific drug delivery system (EtOCDDS) can withstand the harsh stomach and small intestine environments, releasing encapsulated drugs selectively in the colon in response to colonic microflora, exerting local or systematic therapeutic effects. EtOCDDS boasts high colon targetability, enhanced drug bioavailability, and reduced systemic side effects. Polysaccharides are extensively used in enzyme-triggered oral colon-specific drug delivery systems, and its colon targetability has been widely confirmed, as their properties meet the demand of EtOCDDS.
View Article and Find Full Text PDFProstate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and associated lethality. Lack of representation in genomic data means germline testing guidelines exclude for African men. Established that structural variations (SVs) are major contributors to human disease and prostate tumourigenesis, their role is under-appreciated in familial and therapeutic testing.
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- Boreal wildfires in eastern Siberia have been increasing due to a combination of climate factors, leading to higher emissions of carbon dioxide and pollutants.
- About 79% of the increase in summer vapor pressure deficit (VPD), which influences wildfires, is linked to background warming in the eastern Siberian Arctic due to declining sea ice, while 21% is attributed to changing atmospheric conditions.
- Changes in Siberian blocking events are contributing to this issue, as they are becoming more frequent and intense due to warmer conditions, further exacerbating the wildfire situation in the region.
Background: Breast cancer is a heterogeneous disease globally accounting for approximately 1 million new cases annually. Chemotherapy remains the main therapeutic option, but the antitumor efficacy needs to be improved.
Methods: Two multifunctional nanoparticles were developed in this paper using oleic acid and mPEG-PCL as the drug carriers.
Background: Numerous meta-analyses have explored the association between the triglyceride-glucose (TyG) index and diverse health outcomes, yet the comprehensive assessment of the scope, validity, and quality of this evidence remains incomplete. Our aim was to systematically review and synthesise existing meta-analyses of TyG index and health outcomes and to assess the quality of the evidence.
Methods: A thorough search of PubMed, EMBASE, and Web of Science databases was conducted from their inception through to 8 April 2024.
Background: Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking.
Methods: We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes.
Article Synopsis
- The text reviews existing research on the connections between human papillomavirus (HPV) and various cancers, beyond the well-known anogenital and oropharyngeal cancers, highlighting inconsistencies in previous findings.
- An umbrella review was conducted, covering 31 systematic reviews and meta-analyses, and assessed the quality and credibility of the evidence using established tools.
- Findings revealed that while most studies had moderate to high quality, only one HPV type (HPV-18) showed convincing evidence for increased breast cancer risk, whereas HPV was found to be a highly suggestive risk factor for several other cancers, including oral and lung cancer.
Article Synopsis
- Research shows that per- and polyfluoroalkyl substances (PFASs) have possible links to various health issues, but more studies are needed for conclusive findings.
- A systematic review examined 157 meta-analyses assessing PFAS health impacts, indicating moderate-to-high quality results for most studies, particularly highlighting significant associations with low birth weight and immune response.
- While strong evidence connects some PFASs to specific health outcomes, many associations still lack certainty, with a substantial number of potential health effects needing further investigation.
Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of SMG5, a crucial component in nonsense-mediated mRNA decay (NMD) that degrades mRNA containing a premature termination codon, in HCC pathogenesis and therapeutic resistance. We demonstrated an elevated expression of SMG5 in HCC and scrutinized its potential as a therapeutic target.
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