Metformin reduces vascular endothelial dysfunction caused by an acute glucose load in patients with hypertension.

Background: To investigate the effects of a single dose of metformin (MF) on endothelium-dependent vasodilatation and serum antioxidant and free fatty acid levels in patients with primary hypertension (PH) after an acute glucose load.

Materials And Methods: Patients with untreated PH were randomized to a no-metformin group (PH, n = 34) and a metformin group (PH+ MF, n = 28) who received a single dose of 500 mg metformin before testing. Healthy volunteers (n = 31) served as a control group.

Effects of combined glucose and fat load on endothelium-dependent brachial artery vasodilatation in hypertensive patients.

Introduction: This study investigated the effects of combined glucose and fat load on glucose and lipid metabolism, as well as on vascular endothelial function, in hypertensive patients.

Methods And Results: A total of 98 hypertensive patients were randomly divided into 3 groups that received an oral fat tolerance test (OFTT), an oral glucose tolerance test (OGTT) or a combined oral glucose and fat tolerance test (OGFTT). Endothelium-dependent flow-mediated brachial artery dilation (FMD) was measured by vascular ultrasound and was used as an indicator of vascular endothelial function.