[Gene editing technology and its recent progress in disease therapy].

Gene editing is a genetic manipulation technology which utilizes bacterial nucleases to accurately and efficiently modify DNA or RNA. Gene editing has broad applications in basic research, breeding, and drug screening, and it is gaining validity and applicability to the therapy of many diseases especially genetic-based disease. In this review, we summarize the development of gene editing technology, its different strategies and applications in the treatment of disease, and the research of gene editing therapy for genetic diseases (including base editor and epigenetic regulation) in the treatment of disorders and diseases of the blood system, liver, muscle and nervous system.

Prioritizing candidate disease miRNAs by topological features in the miRNA target-dysregulated network: case study of prostate cancer.

Recently, microRNAs (miRNA), small noncoding RNAs, have taken center stage in the field of human molecular oncology. However, their roles in tumor biology remain largely unknown. According to the assumption that miRNAs implicated in a specific tumor phenotype will show aberrant regulation of their target genes, we introduce an approach based on the miRNA target-dysregulated network (MTDN) to prioritize novel disease miRNAs.

MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features.

Synergistic regulations among multiple microRNAs (miRNAs) are important to understand the mechanisms of complex post-transcriptional regulations in humans. Complex diseases are affected by several miRNAs rather than a single miRNA. So, it is a challenge to identify miRNA synergism and thereby further determine miRNA functions at a system-wide level and investigate disease miRNA features in the miRNA-miRNA synergistic network from a new view.

[A study on the mathematical model of normal adult cornea].

Objective: To explore the method on the conic equation to establish the mathematical model of the adult cornea and its preliminary result.

Methods: The curvature of anterior cornea and of posterior cornea, the corneal thickness of the points in the distance of 1.0, 1.

[A study on the space form of the Schematic cornea of the normal adult eye-ball].

Objective: To detect the initial characters of the corneal shape that has been evaluated using a mathematical analysis.

Methods: Subjects were measured with Orbscan II corneal topography system. Anterior and posterior corneal radius of curvature and thickness of the points located 1.