Publications by authors named "Ting-ting Liu"
The preclinical evaluation of drug-induced cardiotoxicity is critical for developing novel drug, helping to avoid drug wastage and post-marketing withdrawal. Although human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and the engineered heart organoid have been used for drug screening and mimicking disease models, they are always limited by the immaturity and lack of functionality of the cardiomyocytes. In this study, we constructed a Cardiomyocytes-on-a-Chip (CoC) that combines micro-grooves (MGs) and circulating mechanical stimulation to recapitulate the well-organized structure and stable beating of myocardial tissue.
View Article and Find Full Text PDFAim: To investigate the regulatory mechanism of CXCL16 molecule-related ( extract-induced antigen presentation in a mouse asthma model based on the long non-coding RNA (lncRNA) and mRNA expression profile.
Methods: knockout mice and wild-type mice were administered with . extract by intratracheal instillations to induce asthma airway inflammation.
Background: Patients with acute pancreatitis (AP) have different sites of pancreatic involvement. The aim of this study was to investigate the differences in magnetic resonance imaging (MRI) findings and clinical features of different sites of involvement (subtypes) in AP, with a view to complement and complete the classification of AP based on anatomical imaging features.
Methods: We consecutively collected data from inpatients with AP from January 2018 to October 2022 at a tertiary care hospital.
Effects of Jintiange on the healing of osteoporotic fractures in aged rats.
J Orthop Surg Res
December 2024
Objective: To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats.
Methods: An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a control group, each with an equal sample size (n = 35). The experimental group received Jintiange capsule ingredients via intragastric administration, while the control group received an equal volume of saline via the same method.
Article Synopsis
- This study explores a new type of polymeric microwave actuator that combines softness with the ability to deform under microwave stimulation, making it suitable for use in advanced devices like soft robots.
- The researchers created a hybrid material using liquid crystal polymer and TiCT (MXene), which dramatically improved the material's sensitivity and energy efficiency, leading to a 230% increase in dielectric loss factor and a 830% boost in energy harvesting efficiency.
- The new actuator demonstrates a rapid response time of nearly 10 seconds and includes a self-powered sensing prototype that provides real-time feedback, offering innovative pathways for efficient electromagnetic applications in smart technologies.
Article Synopsis
- Astigmatic unitary transformations enable the smooth transition between various states of paraxial Gaussian beams, specifically Hermite-Laguerre-Gaussian (HLG) modes, on a modal sphere.
- The research explores how complex structured Gaussian beams, formed from different HLG modal spheres, evolve through astigmatic transformation, leading to unique pattern changes similar to the Talbot effect.
- Using Ince-Gaussian modes for demonstration, the study outlines a new theoretical framework for converting beam structures, potentially leading to innovative applications in the field of structured light.
Article Synopsis
- Phosphorus is essential for plant growth, but its effects on tea plants and the production of theanine, a key flavor and nutritional component, are not well understood.* -
- An increase in inorganic phosphate (Pi) led to a decline in theanine levels in tea leaves and roots, suggesting Pi's negative impact on its biosynthesis.* -
- The study reveals that specific genes and proteins interact to regulate theanine production in response to Pi feeding, providing insights for improving tea quality through fertilization strategies.*
Article Synopsis
- An AI-based model was developed to predict cervical lymph node metastasis (CLNM) in patients with esophageal squamous cell carcinoma (ESCC) using Radiomics and deep learning features from PET/CT images, combined with clinical data.
- The study involved 300 ESCC patients for training and testing, plus an additional 111 patients for external validation; various machine learning algorithms were tested, with logistic regression being the final model chosen.
- The final DL-Radiomics-Clinical (DRC) model showed the best performance metrics, including an AUC of 0.955 and high accuracy rates, indicating its potential as a non-invasive tool for predicting CLNM in ESCC patients.
Article Synopsis
- This study examined the effectiveness and safety of combining nivolumab with chemotherapy for treating advanced HER2-negative gastric cancer (GC).
- A total of 27 patients participated, with a notable response rate of 55.6% and a disease control rate of 74.1%, especially in patients with a combined positive score (CPS) of 5 or higher.
- The findings suggest that this treatment approach could be a new standard for first-line therapy in patients with advanced HER2-negative GC, while the majority experienced manageable side effects.
Article Synopsis
- Radiation-induced lung injury (RILI) causes cell death and fibrosis in lungs, but MSC-derived exosomes can help, although they lack targeting abilities and specific effects.
- A study engineered these exosomes with the SARS-CoV-2 spike protein and the miRNA miR-486-5p to enhance their therapeutic effects.
- The modified exosomes promoted lung cell growth and migration, reduced RILI and fibrosis, and inhibited ferroptosis by regulating fibrosis-related genes both in vitro and in vivo.
Article Synopsis
- Qingshen granule (QSG) has anti-inflammatory and immunoregulatory properties that can help alleviate renal damage caused by renal fibrosis (RF), particularly by affecting dendritic cells (DCs).
- The study used adenine-induced RF animal models to assess how QSG influences immune cell differentiation and function, alongside examining its metabolic effects on glucose and lipid processes in DCs and T cells.
- Results showed that QSG reduced kidney damage, lowered proinflammatory cytokines, altered DC markers, and impacted metabolic gene expression, ultimately promoting DC maturation while inhibiting their migratory ability and antigen presentation to T cells.
Article Synopsis
- Developing non-precious metal-based electrocatalysts for the oxygen evolution reaction (OER) is challenging, but the study successfully creates a composite called CoPO-MoN/NC using a two-step synthesis method.
- This composite shows excellent performance with a low overpotential of 278 mV and maintains stability over 100 hours in alkaline conditions, thanks to the interaction between its components.
- The research highlights how combining different materials can enhance electrocatalytic activity, paving the way for more efficient energy conversion technologies.
Article Synopsis
- - Lithium (Li) is a promising material for future Li-ion batteries due to its high capacity and low density, but issues like Li dendrite growth and volume changes make it hard to use commercially.
- - Researchers have created a new host material, ZnS@NPS-C HRD, which helps control Li deposition and nucleation, addressing the common problems faced with Li metal anodes.
- - This innovative composite shows impressive stability over 300 cycles in certain battery setups and maintains a strong performance with a capacity of 100.91 mAh/g after 400 cycles in a full cell configuration.
Article Synopsis
- Pyroptosis is a type of programmed cell death closely connected to changes in the endoplasmic reticulum (ER) membrane, but the key proteins involved in this process are not well known.
- Researchers developed a chemical probe called α-mangostin (α-MG), which targets the protein reticulon-4 (RTN4), essential for regulating ER shape.
- The study found that reducing RTN4 levels enhances pyroptosis in cancer cells and could lead to promising strategies for cancer treatment and immunotherapy, as high RTN4 levels are linked to tumor growth and patient mortality.
Article Synopsis
- Allogeneic hematopoietic cell transplantation (alloHCT) has shown promising survival benefits for patients with multiple myeloma (MM), particularly in newly diagnosed and relapsed cases, by harnessing its direct cytotoxic and graft-versus-multiple myeloma effects.!* -
- An analysis of 61 studies over the last decade reveals that response rates for complete response (CR), very good partial response (VGPR), and partial response (PR) were 45%, 21%, and 24%, respectively, along with varied one to ten-year overall survival (OS) rates ranging from 36% to 69%.!* -
- Despite a lower initial response and shorter-term survival compared to some other
Article Synopsis
- Insulin influences neuron activity by interacting with insulin receptors and acid-sensing ion channels (ASICs), which are both found in dorsal root ganglia (DRG) neurons.
- A study showed that insulin increases acid-evoked ASIC currents in rat DRG neurons, enhancing their response by about 46% when applied for 5 minutes.
- The insulin-induced increase in ASIC activity is mediated through specific pathways, and insulin also heightens pain responses related to acid, indicating its potential role in pain modulation via ASIC signaling.
Both CXCL10/CXCR3 and acid-sensing ion channels (ASICs) are expressed in nociceptive sensory neurons and participate in various pain processes, but it is still unclear whether there is a link between them. Herein, we report that CXCL10 enhances the electrophysiological activity of ASICs in rat dorsal root ganglia (DRG) neurons. A brief (10 min) application of CXCL10 increased acid-evoked ASIC currents in a concentration-dependent manner.
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- This study explored how n-butanol extract of Pulsatilla Decoction (BEPD) can protect vaginal epithelial cells from damage caused by Candida glabrata through the EGFR/MAPK signaling pathway.
- The research involved creating a vulvovaginal candidiasis (VVC) mouse model and analyzing gene expression differences using transcriptomics, comparing control, VVC model, and BEPD-treated groups.
- Various in vitro experiments assessed the effects of BEPD-containing serum and fluconazole, measuring cell apoptosis and key protein expressions related to inflammation and cell survival to understand the protective mechanisms of BEPD.
Article Synopsis
- The study investigates the adherence of family members to a newly implemented management strategy for H. pylori infection and identifies factors influencing this adherence over a two-year follow-up of 282 families.
- Findings indicate improved adherence rates across various recommendations, with a notable 77% for infection awareness but lower rates for treatment and gastroscopy.
- Key factors influencing adherence included being younger (ages 18-44), having a larger family size, and being aware of symptoms, while occupation and being asymptomatic were linked to lower adherence levels.
Article Synopsis
- - Breast cancer is a widespread health issue, and advancements in treatment have led to increased demand for quality care and longer survival rates.
- - A study analyzed the effects of personalized and continuous care versus routine care in 200 breast cancer patients, measuring psychological and physical health outcomes.
- - Results showed that personalized care significantly reduced anxiety and depression, improved shoulder joint function, lowered complication rates, and enhanced patient satisfaction compared to routine care.
Article Synopsis
- Statins are commonly used to prevent further strokes in patients with mild ischemic stroke, but it is unclear if higher doses are beneficial in Asian populations.
- A study comparing high-dose and moderate-dose statins found no significant difference in stroke recurrence rates at 3 and 12 months, suggesting both doses are similarly effective.
- However, high-dose statins were linked to a higher risk of intracranial hemorrhage, indicating potential safety concerns with more intensive treatment.
Article Synopsis
- The modified pancreatitis activity scoring system (mPASS) is a proposed tool for assessing acute pancreatitis but lacks certain key indicators related to the disease's underlying processes.
- The study aims to identify a threshold for admission mPASS scores and develop a predictive model using radiomics and laboratory parameters to assess the severity of acute pancreatitis.
- Results indicate that a mPASS score of 112.5 can predict severe acute pancreatitis, and a combined model using radiomics and lab data shows promising accuracy in predicting disease activity and prognosis.
Chronic inflammatory demyelinating polyneuropathy with pulmonary nocardiosis: A case report.
Medicine (Baltimore)
June 2024
Article Synopsis
- Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-related disease affecting peripheral nerves, which the authors link to pulmonary nocardiosis in a specific patient case.
- A 65-year-old man with CIDP experienced disease progression despite receiving treatment, and he ultimately developed pulmonary nocardiosis, which led to further health complications.
- Despite attempts to manage both conditions with various therapies, including antibiotics and intravenous immunoglobulin, the patient’s condition deteriorated, and he ultimately died, highlighting the challenges in treating patients with coexisting rare diseases.
Article Synopsis
- This study examined how the progression of Parkinson's disease (PD) is connected to cognitive impairment and changes in serum levels of uric acid (UA) and homocysteine (Hcy).
- It involved 74 patients with PD, using the Montreal Cognitive Assessment (MoCA) to categorize their cognitive function, alongside a control group of 60 individuals without PD.
- Results showed that patients with cognitive impairment had lower UA and higher Hcy levels, with UA being a potential protective factor and Hcy a risk factor for cognitive decline in PD.
Article Synopsis
- Tuberculous meningitis (TBM) is a severe form of tuberculosis that poses challenges in diagnosis and treatment; this study focused on its clinical presentation, diagnosis, and outcomes in China over a decade.
- The study included 341 patients with presumed TBM, categorizing them as confirmed, probable, or possible TBM based on international criteria; various health metrics were recorded and analyzed, revealing significant death risk factors.
- Findings indicated that factors like older age, high TBM scores, severe clinical grading, and specific CSF results were linked to higher mortality; notably, patients with a lower TBM score had better outcomes despite less classic symptoms.