calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes.

Introduction: infection results in various complications in the liver and biliary systems and is a neglected tropical disease in Eastern Asia. In this study, we report that calcium-binding protein Cs16 activates host immune cells and induces immunopathology in liver.

Methods: Immunohistochemistry was used to detect the localization of Cs16 in adult worms.

Soil-transmitted helminthiasis in mainland China from 2016 to 2020: a population-based study.

Background: Soil-transmitted helminthiasis is epidemic in China and many other countries of the world, and has caused substantial burdens to human health. We conducted successive national monitoring in China from 2016 to 2020 to analyze the prevalence, changing trends, and factors influencing soil-transmitted helminthiasis, which provided a reference for future control strategies.

Methods: Soil-transmitted helminth monitoring was carried out in 31 provinces (autonomous regions or municipalities, herein after referred to as "provinces") throughout China.

Prediction of cardiovascular adverse events in newly diagnosed multiple myeloma: Development and validation of a risk score prognostic model.

Background: Multiple myeloma (MM) is the second most common hematological malignancy, and the treatments markedly elevate the survival rate of the patients in recent years. However, the prevalence of cardiovascular adverse events (CVAEs) in MM had been increasing recently. CVAEs in MM patients are an important problem that we should focus on.

Sensitivity and reusability of a simple microbial fuel cell-based sensor for detecting bisphenol A in wastewater.

Polycarbonate plastic processing wastewater contains high concentrations of bisphenol A (BPA), requiring a real-time technology to monitor wastewater containing BPA. Since the activity of electrogenic microorganisms on the anode surface of the microbial fuel cell (MFC) sensor is inhibited by exposure to contaminants, the toxicity of contaminants in wastewater can be determined by observing the variation in voltage output from the MFC sensor. The simple MFC sensor that is developed in this work exhibited a significant decrease in voltage output in BPA-containing wastewater concentration of 5-100 mg/L.

National surveillance of hookworm disease in China: A population study.

Background: Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great.

Methods: The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019.

Soil-transmitted helminthiasis in China: A national survey in 2014-2015.

Background: Based on two national surveys, the prevalence of soil-transmitted helminthiasis (STH) in China had decreased from 53.58% in 1988-1992 to 19.56% in 2001-2004.

From awareness to action: NIPD's engagement in the control of food-borne clonorchiasis.

Clonorchiasis is caused by ingestion of raw freshwater fish containing infective larvae of Clonorchis sinensis. China harbours the largest number of people with C. sinensis infection.

Engagement of the National Institute of Parasitic Diseases in control of soil-transmitted helminthiasis in China.

Soil-transmitted helminthiases (STHs) have been widely transmitted in China and the control of STHs was initiated by NIPD-CTDR since its foundation. Three national surveys on STHs have been carried out in China, and the infection rate has dropped from 53.58% in the first national survey (1988-92) to 4.

Effectiveness of health education in improving knowledge, practice and belief related to clonorchiasis in children.

Clonorchiasis is caused by the ingestion of raw freshwater fish containing Clonorchis sinensis larvae. Health education is crucial in sustainable control of clonorchiasis but extremely challenging when dealing with adults. To investigate if education in children would be a beneficial long-term approach, a cluster-controlled trial was implemented in two primary schools between 2017 and 2019 in Binyang county, Guangxi, China.

National surveillance on soil-transmitted helminthiasis in the People's Republic of China.

Soil-transmitted helminths (STHs) are widely distributed and remain a public health problem in the People's Republic of China. Altogether, 301 counties across 30 regions were investigated during the national surveillance on STHs carried out in 2016 based on the modified Kato-Katz thick smear method to examine faecal samples. A total of 305 081 people were investigated with 7 366 (2.

Surveillance of clonorchiasis in China in 2016.

Clonorchiasis is an important food-borne parasitic disease in China, and infection with C. sinensis can cause hepatobiliary diseases. Comprehensive and systematic prevention and control of clonorchiasis requires the establishment of an effective surveillance.

[Status and working principals of soil-transmitted nematodiasis during new period in China].

The current status of soil-transmitted nematodiasis in China is analyzed. The achievements in prevention and control of soil-transmitted nematodiasis are illustrated. Moreover, the challenges in condition of the decline of soil-transmitted nematodiasis in China are demonstrated.

Assessment of health education products aimed at controlling and preventing helminthiases in China.

Background: Helminthiases have placed a huge burden of disease on the population in China. However, widespread control activities have led to significant achievements. As health education has been widely disseminated and plays an important role in the control and elimination of these diseases, we collected health education products aimed at controlling and preventing helminthiases in China.

[Interpretation of Detection of Intestinal Helminthes-The Kato-Katz Method (WS/T 570-2017)].

The criteria for the Kato-Katz thick smear are compiled following the The criteria are composed of five chapters, including the range of application, terms and definitions, equipments, reagent materials, and testing procedures. Three informative appendices (identification of helminth eggs in human faeces, counting method of eggs in Kato-Katz thick smear, and other considerations) are appended. The criteria have been issued by the National Health and Family Planning Commission of the People's Republic of China, it provides a technical reference for the detection of helminth eggs in human faeces in medical institutions and disease prevention and control institutions.

[Establishing evaluation system for health education products of parasitic diseases by Delphi method].

Objective: To establish an evaluation system for health education products of parasitic diseases by using a Delphi method, so as to provide references for the evaluation of health education products.

Methods: An expert panel was established and evaluation indicators were determined by brainstorming and face-to-face discussion, then the weight of each evaluation indicator was determined through a two-round Delphi method and the evaluation system was established.

Results: The evaluation indicators for material products, graphic design products and audio-visual products were established respectively by expert panel.

[Interpretation of Diagnostic Criteria for Clonorchiasis].

infection is carcinogenic to human, which results in cholangiocarcinoma, confirmed by the World Health Organization. An investigation in 2005 indicated that the standardized infection rate was 0.58%, with 12 490 000 infected people estimated in the clonorchiasis endemic areas in China.

[Analysis of results of Assessment on National Parasitic Disease Control and Prevention Techniques in 2015].

Objective: To assess the theoretical knowledge and practical skills of parasitic diseases among technicians from disease control and prevention institutions.

Methods: The Assessment on National Parasitic Disease Control and Prevention Techniques was organized in September, 2015. Together, 124 subjects from disease control and prevention institutions at province, prefecture or county levels in 31 provinces joined the assessment.

[Analysis of capability of examining helminthes: National technique competition of parasitic disease diagnosis in 2013].

Objectives: To understand the ability of worm detection of staff of centers for disease control and prevention (CDC) in China, so as to promote the ability construction.

Methods: In each province, four competitors were selected from the institutions of parasitic diseases control to attend the National Technique Competition for Parasitic Disease Diagnosis and the results of competition were collected and analyzed.

Results: The average scores of microscopic identification and slide preparation of all the 124 competitors were 27.

Risk factors for Enterobius vermicularis infection in children in Gaozhou, Guangdong, China.

Background: Enterobius vermicularis infection is a prevalent intestinal parasitic disease in children. In this study, we explored the epidemiological status and risk factors for E. vermicularis infection in children in southern China.

[Enterobius vermicularis infection status among children in 9 provinces/autonomous regions/municipalities of China].

Objective: To investigate the infection status of Enterobius vermicularis among children in 9 Provinces/Autonomous regions/Municipalities (P/A/M) of China, and analyze its risk factors.

Method: From April to December 2011, one provincial capital (prefecture-level city) and one county (city, district) were chosen as investigation spots from Guangdong, Guangxi, Hainan, Chongqing, Sichuan, Zhejiang, Fujian, Anhui and Guizhou, respectively. Children aged 2 to 12 were examined by using adhesive cellophane anal swab with round-bottom tube.

An Outbreak of Human Fascioliasis gigantica in Southwest China.

Fascioliasis is a common parasitic disease in livestock in China. However, human fascioliasis is rarely reported in the country. Here we describe an outbreak of human fascioliasis in Yunnan province.

Epidemiological profile of Clonorchis sinensis infection in one community, Guangdong, People's Republic of China.

Background: Clonorchiasis caused by ingesting improperly prepared fish ranks among the most important but still neglected food-borne parasitic diseases, especially in the People's Republic of China (P.R. China).

[Analysis of influencing factors of Trichuris trichiura infection in demonstration plots of comprehensive control of parasitic diseases].

Objective: To understand the main risk factors of Trichuris trichiura infection in plots carrying out the integrated control of parasitic diseases.

Methods: The simple and multiple unconditional logistic regression were applied to analyze related data from the database of baseline survey in demonstration plots carrying out the integrated control of parasitic diseases.

Results: The results of simple logistic regression analysis suggested that the effects of 7 factors to Trichuris trichiura infection were significant (all P values were less than 0.

[Prevention and treatment of ascariasis in demonstration plots of integrated control from 2006 to 2009].

Objective: To understand the situation of Ascaris lumbricoides infection in the demonstration plots and evaluate the effect of integrated intervention measures.

Methods: The integrated intervention measures included health education, mass chemotherapy, safe water and sanitary toilets. The changes of infection rates of Ascaris lumbricoides in residents were observed before and after the intervention.