Two Vanilloid Ligand Bindings Per Channel Are Required to Transduce Capsaicin-Activating Stimuli.

The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals has evolved the capability to integrate pain signal arising from harmful temperature and chemical irritants. The four repetitions of TRPV1 subunits result in an ion channel with excellent pain sensitivity, allowing this ionotropic receptor to differentiate graded injuries. We manipulated the stoichiometry and relative steric coordination of capsaicin-bound structures at the molecular level to determine the rules by which the receptor codes pain across a broad range of intensities.

[Zero-Valent Iron (ZVI) Activation of Persulfate (PS) for Oxidation of Arsenic (Ⅴ) Form Aqueous Solutions].

Arsenic is one of the most toxic substances yet discovered and arsenic contamination of water has become a global environmental problem in need of a solution. This study has identified the capacity of sodium persulfate (PS), activated by zero-valent iron (ZVI) to remove As(Ⅴ) from waste-water is much greater than the capacity of PS alone due to the production of sulfate radicals in the process. Five parameter types including PS and ZVI dosage, reaction temperature, initial pH value, and initial As(Ⅴ) concentration are discussed in detail.

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.

One of the pathological hallmarks of Alzheimer's disease is the presence of insoluble extracellular amyloid plaques. These plaques are mainly constituted of amyloid beta peptide (A beta), a proteolytic product of amyloid precursor protein (APP). APP processing also generates the APP intracellular domain (AICD).