Publications by authors named "Ting-Xiao Chen"
Article Synopsis
- Flavonoids, particularly 7,8-dihydroxyflavone (7,8-DHF) and 7-hydroxyflavone (7-HF), were studied for their antioxidant properties in RAW264.7 cells subjected to oxidative stress.
- Using various assays, the study found that 7,8-DHF exhibited stronger antioxidant effects than 7-HF by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels while enhancing superoxide dismutase (SOD) activity.
- The mechanisms revealed that 7,8-DHF inhibited cellular damage pathways and boosted protective proteins, indicating its potential as a drug to combat oxidative stress injuries.
A series of diclofenac hybrid molecules were synthesized and evaluated for their NO-inhibitory ability in LPS-induced RAW 264.7 macrophage cells. Among them, compound 1 showed the highest NO-inhibitory ability (approximately 66%) and no significant cytotoxicity.
View Article and Find Full Text PDFEthnopharmacological Relevance: Aesculetin (6,7-dihydroxy-2H-1-benzopyran-2-one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo.
Aims Of This Study: In this study, we evaluated the anti-inflammatory effect and investigated underlying molecular mechanisms of aesculetin in LPS-induced RAW264.7 macrophages and DSS-induced colitis.