Facile Synthesis of Ultramicroporous Organic-Linked Zincophosphate with High Thermal, Chemical and Water Stabilities.

The application of ultramicroporous materials for CO2 separation is limited by the rarity of materials exhibiting stability and rapid scale-up characteristics. In this study, we propose a rational approach to enhance the structural stability and durability of the pillared layer structure. Through the topotactic replacement of protons with metal ions in the parent 4,4'-bipyridine (bpy)-pillared zincophosphate, we observed the formation of edge-sharing dimers of ZnO4N and PO4, as well as the insertion of (VOH2O)2+ into the zinc phosphate layers.

κ Opioid Receptor-Dynorphin Signaling in the Central Amygdala Regulates Conditioned Threat Discrimination and Anxiety.

Neuropeptides within the central nucleus of the amygdala (CeA) potently modulate neuronal excitability and have been shown to regulate conditioned threat discrimination and anxiety. Here, we investigated the role of κ opioid receptor (KOR) and its endogenous ligand dynorphin in the CeA for regulation of conditioned threat discrimination and anxiety-like behavior in mice. We demonstrate that reduced KOR expression through genetic inactivation of the KOR encoding gene, , in the CeA results in increased anxiety-like behavior and impaired conditioned threat discrimination.