Depilatory creams increase the number of hair follicles, and dermal fibroblasts expressing interleukin-6, tumor necrosis factor-α, and tumor necrosis factor-β in mouse skin.

Besides using for hair removal, depilatory agents have been considered to be used as a penetration enhancer for transepidermal drug delivery. To examine the effect in hair follicles (HFs), two commercially available depilatory creams were tested on the dorsal skin of mice to monitor the effect deep into the skin structure. Fifteen male BALB/c mice were used in this study.

Perspiration promotes the effect of sulphite on the shielding response of rodent skin.

Perspiration and environmental chemicals, such as air pollutants, are two of the complicating factors of skin disease. It has not been studied how perspiration affect the skin responding to air pollutants. We applied topically artificial eccrine perspiration, sulphite or both to the mouse skin for one and two weeks to examine the influence of both factors on the shielding ability of healthy skin.

Shielding response of rodent skin to water soluble ambient air pollutants.

Given the increasing levels of air pollution, understanding the direct shielding response of the skin to air pollutants as a whole under exclusion of the influence from the inside of body is important. We applied topically the water soluble ambient air pollutants to the mouse skin and observed the histological response using 0.3 mM of HSO as a positive control.