Effects of Bioceramic Material and Colored Light Irradiation on Learning and Memory in Aging Rats.

Aging is characterized by molecular damage from free radicals, leading to neural dysfunction and memory impairment. This study investigated using bioceramic material and colored light to mitigate neurodegenerative symptoms in aging rats. We assessed the effects of different color light spectrums on D-galactose-induced aging rats using the Morris water maze, novel object recognition, and open field tests.

Disclosing Critical Voice Features for Discriminating between Depression and Insomnia-A Preliminary Study for Developing a Quantitative Method.

Depression and insomnia are highly related-insomnia is a common symptom among depression patients, and insomnia can result in depression. Although depression patients and insomnia patients should be treated with different approaches, the lack of practical biological markers makes it difficult to discriminate between depression and insomnia effectively. This study aimed to disclose critical vocal features for discriminating between depression and insomnia.

Establishment of a basic medical science system for Traditional Chinese medicine education: A suggestion based on the experience of BIOCERAMIC technology.

The aim of this review study is to present an integrated and systematic approach to meridian channels and Ashi acupuncture points based on scientific evidence. We herein establish a framework of basic medical science to explain meridian channels based on the(1) Concepts of Traditional Chinese medicine(TCM) approach using physics and physiology: (i) the physical theory of pulse sound and cardiovascular physiology: resonance of harmonic sounds and the specific frequencies arising from heartbeats, which form pathways of different meridian channels to enhance microcirculation; (ii) standing wave hypothesis to explain meridian channels; (iii) Ashi acupuncture or trigger points caused by ischemia due to inappropriate harmonic resonance of standing waves; and (2)the TCM concept strengthened by BIOCERAMIC technology: (i) 'wave-induced flow characteristics of meridians'; (ii) the 'Propagated sensation along meridian' phenomenon; (iii) clinical observations of the different chief complaints of candidates in which sensation was induced along specific meridian channels; (iv) generates 'biofield' phenomenon composed of virtual channels of interconnecting 'feet-hands-ears' to different internal organs/tissues that support the principles of reflexology.

Base on concept of traditional Chinese medicine: Experimental studies on efficacy of BIOCERAMIC Resonance to alleviate drug withdrawal symptoms.

Those who are challenged by dependency on prescription drugs or suffer drug addictions have few options available to them for recovery, such as psychotherapy and physiotherapy. Here we present a new approach with clinical examples involving stimulant addiction or overdose of hypnotic drugs that were received BIOCERAMIC Resonance, which was developed based on concept of 12 meridian channels of traditional Chinese medicine, and has successful withdrawal or dose reduction benefits. We describe the whole process and the clinical outcome.

A technology developed from concept of acupuncture and meridian system, the clinical effect of BIOCERAMIC resonance on psychological related sleep disturbance with findings on questionnaire, EEG and fMRI.

Under the concept of meridian channels that belongs to traditional Chinese medicine, BIOCERAMIC Resonance (BR) has already been applied to many clinical medical research projects with functions mimicking of traditional acupuncture. Forty-five patients were recruited with chronic sleep disorders; 36 patients were given, applied to the device with BIOCERAMIC material and sound rhythm on chest skin surface; 9 patients were included as controls. All study participants completed a sleep pattern and quality of life questionnaire (assessment on psychological and physical causes of sleep disturbances), which was repeated before, during and after treatment.

The Effect of Photoluminescence of Bioceramic Irradiation on Middle Cerebral Arterial Occlusion in Rats.

The purpose of this study is to determine the possible effect of photoluminescence of bioceramic (PLB) on ischemic cerebral infarction (stroke), by using an animal model of transient middle cerebral artery occlusion (MCAO). Sprague-Dawley rats were used to induce MCAO to block the origin of the left MCAO; three months later, the positive chronic stroke rats were selected by running tunnel maze; the MCAO rats with significant chronic stroke and neurological defects were used for treadmill experiments with varying speed settings to test their capability for restoration after muscular fatigue under conditions of with and without PLB irradiation. As a result, PLB irradiation could improve exercise completion rate and average running speed during slow and fast treadmill settings.

Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex.

Background: Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER) positive breast cancer in pre- and post-menopausal women. However, using tamoxifen routinely to inhibit endogenous or exogenous estrogen effects is occasionally difficult because of its potential side effects.

Objectives: The aim of this study is to design a local drug delivery system to encapsulate tamoxifen for observing their efficacy of skin penetration, drug accumulation and cancer therapy.

Evaluation of Reflexology by "BIOCERAMIC Resonance" Operation producing Weak Force Field during Simultaneous Acupoint Stimulation of Urinary Bladder Point on Subject's Ear Resulting in Electric Current Change on Urinary Bladder reflex Point on Subject's Hands, and Related New Research Finding.

Objective: It was postulated in our previous publications that the meridian channels as conceived in Traditional Chinese Medicine (TCM) are various standing waves arising from harmonic rhythmic sound frequencies originating from the human heart beat. BIOCERAMIC is an artificial material able to produce a weak force field causing different biophysical and systemic health benefits, with the key characteristics of hydrogen bonds weakening and microcirculation enhancement. Since discovering that the effects of a BIOCERAMIC field can be transmitted via sound waves propagation, we then also developed a BIOCERAMIC Resonance device to produce weak force field throughout the body, and achieve resonance with the body's meridian channels to reinforce microcirculation.

Bioceramic Resonance Effect on Meridian Channels: A Pilot Study.

Bioceramic is a kind of material which emits nonionizing radiation and luminescence, induced by visible light. Bioceramic also facilitates the breakup of large clusters of water molecules by weakening hydrogen bonds. Hydrogen bond weakening, which allows water molecules to act in diverse ways under different conditions, is one of the key mechanisms underlying the effects of Bioceramic on biophysical and physical-chemical processes.

The Analysis of Normalized Effects on Meridian Current Level After the Photoluminescent Bioceramic Treatment on Acupuncture Points.

Objective: This study investigated the advantage of photoluminescent bioceramic (PLB) irradiation on meridian channels of abnormal meridian currents, as well as the normalization of meridian current levels that may represent the participants' physiologic conditions.

Design: Statistical analysis of survey data.

Participants: Forty-six patients with abnormal meridian current in the gallbladder (GB).

In Vitro and In Vivo Studies of the Biological Effects of Bioceramic (a Material of Emitting High Performance Far-Infrared Ray) Irradiation.

Bioceramic is a material that emits high performance far-infrared ray, and possess physical, chemical and biological characteristics on irradiation of water, particularly to in reducing the size of water clusters, weakening of the hydrogen bonds of water molecules and other effects on physical and chemical properties of water. In this review paper, we summarized the in vivo and in vitro biological effects of Biocermaic, and included previous published data on nitric oxide, calmodulin induction on cells, effects of bioceramic on intracellular heat shock protein and intracellular nitric oxide contents of melanoma cells, antioxidant effects of Bioceramic on cells and plants under H₂O₂-mediated oxidative stress, effects on anti-oxidative stress of myoblast cells and on preventing fatigue of amphibian skeletal muscle during exercise, anti-inflammatory and pain relief mechanism, effects on the chondrosarcoma cell line with prostaglandin E2 production, effects on the rabbit with inflammatory arthritis by injection of lipopolysaccharides under monitoring by positron emission tomography scan, effects on psychological stress-conditioned elevated heart rate, blood pressure and oxidative stress-suppressed cardiac contractility, and protective effects of non-ionized radiation against oxidative stress on human breast epithelial cell. We anticipate that the present work will benefit medical applications.

Dendritic cells respond to nasopharygeal carcinoma cells through annexin A2-recognizing DC-SIGN.

Dendritic cells (DCs) play an essential role in immunity and are used in cancer immunotherapy. However, these cells can be tuned by tumors with immunosuppressive responses. DC-specific intercellular adhesion molecule 3-Grabbing Nonintegrin (DC-SIGN), a C-type lectin expressed on DCs, recognizes certain carbohydrate structures which can be found on cancer cells.

Physiological effects of bioceramic material: harvard step, resting metabolic rate and treadmill running assessments.

Previous biomolecular and animal studies have shown that a room-temperature far-infrared-rayemitting ceramic material (bioceramic) demonstrates physical-biological effects, including the normalization of psychologically induced stress-conditioned elevated heart rate in animals. In this clinical study, the Harvard step test, the resting metabolic rate (RMR) assessment and the treadmill running test were conducted to evaluate possible physiological effects of the bioceramic material in human patients. The analysis of heart rate variability (HRV) during the Harvard step test indicated that the bioceramic material significantly increased the high-frequency (HF) power spectrum.

Wave-induced flow in meridians demonstrated using photoluminescent bioceramic material on acupuncture points.

The mechanisms of acupuncture remain poorly understood, but it is generally assumed that measuring the electrical conductivity at various meridians provides data representing various meridian energies. In the past, noninvasive methods have been used to stimulate the acupuncture points at meridians, such as heat, electricity, magnets, and lasers. Photoluminescent bioceramic (PLB) material has been proven to weaken hydrogen bonds and alter the characteristics of liquid water.

Effects of far-infrared irradiation on myofascial neck pain: a randomized, double-blind, placebo-controlled pilot study.

Objectives: The objective of this study was to determine the relative efficacy of irradiation using a device containing a far-infrared emitting ceramic powder (cFIR) for the management of chronic myofascial neck pain compared with a control treatment.

Design: This was a randomized, double-blind, placebo-controlled pilot study.

Participants: The study comprised 48 patients with chronic, myofascial neck pain.

A static magnetic field attenuates lipopolysaccharide-induced neuro-inflammatory response via IL-6-mediated pathway.

An effective method for controlling brain damage and neurodegeneration caused by inflammation remains elusive. Down-expression of the lipopolysaccharide (LPS)-induced inflammatory cytokines resulting in endotoxin tolerance is reported as an alternative anti-infection treatment. Nonetheless, because the dosage and action site are hard to control, endotoxin tolerance caused by low-dose LPS injection in brain tissue may induce side effects.

Apoptotic toxicity of destruxin B in human non-Hodgkin lymphoma cells.

Destruxins are fungal toxins used as insecticides. Recent reports demonstrated the potential anti-cancer activities of destruxin B (DB). This study is to discover the effects of DB in lymphoma.

Effects of far infrared rays irradiated from ceramic material (BIOCERAMIC) on psychological stress-conditioned elevated heart rate, blood pressure, and oxidative stress-suppressed cardiac contractility.

The present study examined the effects of BIOCERAMIC on psychological stress-conditioned elevated heart rate, blood pressure and oxidative stress-suppressed cardiac contractility using in vivo and in vitro animal models. We investigated the effects of BIOCERAMIC on the in vivo cardiovascular hemodynamic parameters of rats by monitoring their heart rates, systolic blood pressure, mean blood pressure and diastolic blood pressure. Thereafter, we assayed its effects on the heart rate in an isolated frog heart with and without adrenaline stimulation, and on cardiac contractility under oxidative stress.

Bone and joint protection ability of ceramic material with biological effects.

Ceramic materials with biological effects (bioceramic) have been found to modulate various biological effects, especially those effects involved in antioxidant activity and hydrogen peroxide scavenging. As arthropathy and osteopathy are the major chronic diseases of geriatric medicine, we explored the possible activity of bioceramic on these conditions using animal and cell models. Rabbits received intra-articular injections of lipopolysaccharides (LPS) to induce inflammation that mimic rheumatic arthritis.

A Pilot Study of Ceramic Powder Far-Infrared Ray Irradiation (cFIR) on Physiology: Observation of Cell Cultures and Amphibian Skeletal Muscle.

The purpose of this research was to assess the potential for far-infrared ray irradiation from ceramic powder to improve exercise performance at room temperature. We designed experiments with murine myoblast cells (C2C12) to study the effect of cFIR irradiation on cell viability and lactate dehydrogenase release under H2O2-mediated oxidative stress and evaluated intracellular levels of nitric oxide and calmodulin. We also used electro-stimulation of amphibian skeletal muscle.

Anti-Inflammatory mechanisms of the proteinase-activated receptor 2-inhibiting peptide in human synovial cells.

Background: Osteoarthritis (OA) is a degenerative joint disease which affects the entire joint structure, including the synovial membrane. Disease progression was shown to involve inflammatory changes mediated by proteinase-activated receptor (PAR)-2. Previous studies demonstrated that PAR-2 messenger (m)RNA and protein levels increased in OA synovial cells, suggesting that PAR-2 is a potential therapeutic target of the disease.

Can breast magnetic resonance imaging demonstrate characteristic findings of preoperative ductal carcinoma in situ in Taiwanese women?

Objective: Magnetic resonance imaging (MRI) is more sensitive than mammography and sonography for breast cancer detection, but its diagnostic specificity is still being debated, and standardised criteria are lacking.

Methods: This study used a dedicated breast MRI system with a Spiral RODEO pulse sequence, and applied postprocessing techniques including multiplanar reformation (MPR) with ductal orientation, early subtracted phase (ESP) and a postcontrast kinetic curve. We discuss the possible MRI/pathology correlations based on pathogenetic concepts.