SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice.

Most rice () cultivars cannot survive under prolonged submergence. However, some ssp. cultivars, such as FR13A, are highly tolerant owing to the () allele, which encodes a Group VII ethylene-responsive factor (ERFVII) protein; other submergence-intolerant cultivars contain a allele.