Publications by authors named "Ting- Gong"

Aim And Objective: Magnoliae Flos (Chinese name: Xin-Yi) and Xanthii Fructus (Chinese name: Cang-Er-Zi) are Chinese herbal medicines and have been used to treat allergic rhinitis (AR). However, the therapeutic effect, active ingredients, and probable processes of a compound of Magnoliae Flos and Xanthii Fructus in the form of essential oils (CMFXFEO) in treating AR have not been reported. This study aims to determine the efficacy of the CMFXFEO on ovalbumin (OVA)-induced AR in a rat model and to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of CMFXFEO against AR.

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Quantum dot (QD)-converted micrometer-scale light-emitting diodes (micro-LEDs) are regarded as an effective solution for achieving high-performance full-color micro-LED displays because of their narrow-band emission, simplified mass transfer, facile drive circuits, and low cost. However, these micro-LEDs suffer from significant blue light leakage and unsatisfactory electroluminescence properties due to the poor light conversion efficiency and stability of the QDs. Herein, the construction of green and red QD luminescence microspheres with the simultaneously high conversion efficiency of blue light and strong photoluminescence stability are proposed.

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Pressurized hot water, as a green and efficient physical treatment technology, has been widely utilized for the extraction and modification of polysaccharides, with the objective of enhancing the physicochemical properties and biological activities of polysaccharides applied in food systems. This article reviews the recent advances regarding the effects of pressurized hot water treatment (extraction and modification) on polysaccharide extraction rates, structure, physicochemical properties, and bioactivities. The potential modes and mechanisms of polysaccharides subjected to pressurized hot water treatment and the relevant applications of these treated polysaccharides are also thoroughly discussed.

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Effective Microorganism (EM) is widely employed as a growth promoter in agricultural practices. The aging of oat seeds not only directly impairs agricultural production but also exerts adverse effects on biodiversity. The mechanism through which EM influence the germination of aging seeds remains unclear.

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Article Synopsis
  • Gastric cancer has a poor prognosis and varied cellular characteristics, highlighting the need for a better understanding of its tumor microenvironment and heterogeneity to create effective treatments.
  • Researchers analyzed single-cell RNA sequencing data and used machine learning to identify 18 significant genes related to gastric cancer, with a particular focus on NFKBIE, which showed a strong correlation with patient risk levels.
  • The study suggests NFKBIE could serve as a potential biomarker and therapeutic target, with certain drugs like gemcitabine and chloropyramine possibly being effective against high-risk gastric cancer patients.
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Tank-binding kinase 1 (TBK1) is a critical signal transducer in the nuclear factor κB (NF-κB) and interferon regulatory factor (IRF) pathways, essential for innate immunity. However, its negative regulation mechanisms remain unclear. This study demonstrates that TBK1 succinylation, regulated by desuccinylase SIRT5, inhibits lipopolysaccharide (LPS)/Toll-like receptor 4 (TLR4)-mediated NF-κB and IRF signaling activation.

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Introduction: The first-line standard therapy for advanced HER2-positive gastric cancer is chemotherapy combined with trastuzumab and pembrolizumab, while pembrolizumab alone does not benefit as a monotherapy in patients with mismatch repair proficiency (pMMR). This case explores the therapeutic potential of adding pembrolizumab to patients who were resistant to trastuzumab, focusing on the synergistic effect of an immune checkmate inhibitor, combined with HER2 antibody.

Case Presentation: An 87-year-old metastatic gastric cancer patient, whose medical history was significant for intolerance to chemotherapy and had a poor status of performance.

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Early detection of cancer significantly improves patient outcomes, with biomarkers offering a promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have emerged as a powerful tool for detecting these biomarkers in body fluids, providing enhanced sensitivity, specificity, and rapid analysis. This review focuses on recent advances in microfluidic biosensors from 2018 to 2024, detailing their operational principles, fabrication techniques, and integration with nanotechnology for cancer biomarker detection.

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  • EphrinB2 is crucial for promoting the formation of blood and lymph vessels during embryo development and plays a significant role in cardiac lymphangiogenesis after a heart attack (myocardial infarction, MI).
  • The study found that EphrinB2 helps prevent heart remodeling and dysfunction post-MI by activating pathways involved in lymphangiogenesis, with its absence leading to worsening heart conditions.
  • Mechanistically, EphrinB2 enhances the proliferation and migration of lymphatic endothelial cells, boosts the activity of a specific transcription factor (ISL1), and its effects are diminished when the VEGFR3 pathway is inhibited, highlighting its importance in cardiac recovery after MI.
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The attitudes of the general public with regard to social welfare are of crucial importance in determining the efficacy and stability of a nation's welfare system. The manner in which taxation is employed as a means of funding mechanism for welfare policies is of great consequence. Nevertheless, existing research on the subject of welfare attitudes has largely neglected the tax perspective, underscoring the need for investigations that bridge this gap and provide a more comprehensive understanding of the intertwined dynamics between taxation and public perception of social benefits.

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  • * The review examines how silymarin is absorbed and metabolized in the body, focusing on its anti-inflammatory effects through pathways like NF-κB and MAPK.
  • * This research highlights the potential of silymarin to modify diseases and supports the need for further clinical studies to explore its therapeutic applications.
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Background: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for non-small cell lung cancer (NSCLC). The variability in patient responses necessitates a blood-based, multi-cohort gene signature to predict ICI response in NSCLC.

Methods: We performed transcriptomic profiling of peripheral blood mononuclear cell (PBMC) and buffy coat (BC) samples from three independent cohorts of NSCLC patients treated with ICIs: a retrospective cohort (PMBCR, n = 59), a retrospective validation cohort (BC, n = 44), and a prospective validation cohort (PBMCP, n = 42).

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Taste receptor type 1 subunit 3 (T1R3) is a G protein-coupled receptor encoded by the TAS1R3 gene that can be specifically activated by certain sweeteners or umami agents for sweet/umami recognition. T1R3 is a potential target for regulating male reproduction. However, studies on the impact of non-nutritive sweeteners on reproduction are limited.

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Ginsenosides are major active components of , which are generally glycosylated at C3-OH and/or C20-OH of protopanaxadiol (PPD) and C6-OH and/or C20-OH of protopanaxatriol. However, the glucosides of dammarenediol-II (DM), which is the direct precursor of PPD, have scarcely been separated from . Because different positions and numbers of the hydroxyl and glycosyl groups lead to a diversity of structure and function of the ginsenosides, it can be inferred that DM glucosides may have different pharmacological activities compared with natural ginsenosides.

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  • - Sepsis often causes high lactate levels and acute lung injury (ALI), with clinical studies linking elevated lactate to higher mortality in septic patients.
  • - Researchers found that during sepsis, lactate triggers changes in cold-inducible RNA-binding protein (CIRP) within macrophages, leading to the release of CIRP, which then interacts with pulmonary vascular endothelial cells (PVECs) to promote cell death pathways.
  • - The study reveals that lactate-induced CIRP release stabilizes Z-DNA binding protein 1 (ZBP1) in PVECs, exacerbating ALI through a cell death mechanism known as PANoptosis, emphasizing a potentially new target for treating sepsis-related complications. *
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  • The study investigates immune checkpoint inhibitor (ICI)-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), aiming to identify unique clinical features and mechanisms compared to non-ICI-induced cases.
  • It analyzed 41 ICI-induced SJS/TEN cases against 107 non-ICI cases, revealing ICI cases often have a longer latency period, a smaller body surface area affected, and less severe mucositis.
  • The research suggests that PD-1 inhibitors are primarily responsible for these reactions, with a mortality rate of 24.5%, offering insights into treatment approaches and the underlying immune mechanisms involved.
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Sepsis-induced acute lung injury (ALI), characterized by severe hypoxemia and pulmonary leakage, remains a leading cause of mortality in intensive care units. The exacerbation of ALI during sepsis is largely attributed to uncontrolled inflammatory responses and endothelial dysfunction. Emerging evidence suggests an important role of Z-DNA binding protein 1 (ZBP1) as a sensor in innate immune to drive inflammatory signaling and cell death during infections.

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  • Toxic epidermal necrolysis (TEN) is a severe and potentially deadly skin reaction caused by common medications, featuring rapid skin detachment due to cell death, with no effective treatments currently available.
  • Researchers used deep visual proteomics to analyze skin biopsies from TEN patients, identifying significant changes in proteins related to type I and II interferon signaling and activated phosphorylated STAT1, which are believed to drive the condition.
  • The study found that using JAK inhibitors, like tofacitinib and baricitinib, effectively reduced skin damage in both mouse models and human patients with TEN, indicating these pathways could be targeted for potential new treatments.
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  • Recent studies suggest that biologics like ustekinumab and secukinumab are effective for treating generalized pustular psoriasis (GPP), but their comparative effectiveness and safety remain unclear.
  • This study aimed to evaluate the efficacy and safety of both drugs in GPP patients over 48 weeks, including genetic analysis of CARD14 mutations.
  • Results indicated secukinumab outperformed ustekinumab in terms of quicker skin clearance and improved quality of life, with outcomes unaffected by CARD14 mutations.
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  • The study aimed to create a new MRI pulse sequence called PRIME, which improves diffusion MRI by adding an echo to obtain high-resolution images without increasing scan time.
  • The PRIME technique uses two echoes: one for detailed diffusion imaging and the second for generating accurate field maps or matching resolutions for efficient data acquisition.
  • Results showed that the PRIME sequence successfully achieved fast and clear diffusion imaging in healthy volunteers, allowing for high-quality images and detailed analysis without distortion.
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This paper aims to explore the application of visual image big data (BD) in art management, and proposes and develops a new art management model. First of all, this study conducted extensive research on the overview and application of big data, focusing on analyzing the characteristics of big data and its characteristics and application methods in art management. By introducing image processing (IP) technology, this paper expounds on the application of visual image technology in art management in detail and discusses the classification of computer vision images to determine its application direction.

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