Glycosyltransferase-Mediated Modulation of Reactive Oxygen Species Enhances Non-host Resistance to Pst DC3000 in Nicotiana benthamiana.

Non-host resistance (NHR) governs defense responses against a broad range of potential pathogen species in contrast with host resistance. To identify specific genes involved in disease resistance, we used a virus-induced gene-silencing screen in Nicotiana benthamiana and identified glycosyltransferase (NbGT) as an essential component of NHR. NbGT silencing enhanced the hypersensitivity response, reactive oxygen species response, and callose deposition in N.

Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2.

Background: Orthodontic treatment applies specific corrective forces to teeth, transmitting stress to periodontal tissue, thereby regulating the growth and development of periodontal ligament stem cells (PDLSCs). Recently, N-acetyltransferase 10 (NAT10) mediated N4-acetylcytidine (ac4C) modification is demonstrated to play a key role in the osteogenic differentiation of stem cells. Therefore, this study aimed explore the effects of Orthodontic treatment on the NAT10 mediated ac4C modification and osteogenic differentiation of PDLSCs.

Physiological and transcriptomic analysis reveal the regulation of adventitious root formation in Cinnamomum parthenoxylon cuttings.

Cinnamomum parthenoxylon is a significant essential oil plant in southern China, however, the challenge of rooting cuttings poses a hindrance to its development and widespread cultivation. Adventitious root (AR) formation is a vital mechanism for plants to acclimate to environmental changes, yet the precise regulatory mechanisms governing this process remain largely unknown. This study investigated the morphological, physiological, and transcriptomic alterations during AR formation in C.

A review of clinical practice guidelines on the management of preeclampsia and nursing inspiration.

Objectives: To review, evaluate, and synthesize the recommendations of guidelines on preeclampsia (PE) from a nursing perspective.

Methods: This is a systematic review of international and national guidelines on PE. Electronic databases and related guideline websites were searched from 2013 to 2023.

Sirolimus alleviated intractable diarrhea of IPEX syndrome: a case report and literature review.

Background: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare single-gene X-linked immunodeficiency disease caused by mutations in the forkhead box protein 3 (FOXP3) gene. The typical clinical manifestations of IPEX mainly include severe atopic dermatitis, insulin-dependent type 1 diabetes mellitus, and intractable diarrhea.

Case Presentation: Here, we report a boy with intractable diarrhea diagnosed with early-onset IPEX syndrome due to the c.

The correlation between protein energy wasting and the incidence of main adverse cardiovascular events in adult maintenance hemodialysis patients: a single-center retrospective cohort study.

Background: Protein energy wasting (PEW) is prevalent in adult maintenance hemodialysis (MHD) patients. Concurrently, cardiovascular diseases (CVD) remain a leading cause of mortality in MHD patients. However, the relationship between PEW and CVD in MHD patients remains unclear.

Circular RNA NINL accelerates the malignant progression of cervical cancer.

Objective: The study's aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC).

Methods: Tumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues were detected.

NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis.

Various factors play key roles in maintaining intestine homeostasis. Disruption of the balance may lead to intestinal inflammatory diseases (IBDs) and even colorectal cancer (CRC). Loss or gain of function of many key proteins can result in dysregulated intestinal homeostasis.

Efficacy of Perineural Dexmedetomidine in Ultrasound-guided Interscalene Block on Rebound Pain after Shoulder Arthroscopy.

Objectives: This prospective, randomized, double-blind trial was performed to investigate the effect on rebound pain incidence of mixing dexmedetomidine (DEX) with local anesthetics in a combined injection interscalene block (ISB) during shoulder arthroscopy.

Methods: 47 patients were enrolled in this study. Patients were randomly assigned to 2 groups: Group DEX and Group Control received ultrasound-guided ISB using 12 mL of 0.

Factors associated with social isolation in stroke patients: a systematic review and meta-analysis.

Objective: Systematic evaluation of factors influencing social isolation in stroke patients for further intervention studies.

Methods: We searched for observational studies in 7 databases from inception to January 2024. Two researchers performed literature screening, quality assessment, and data extraction independently according to inclusion and exclusion criteria, and meta-analysis was performed using R4.

Fecal Microbiota Transplantation in Children with Autism.

Purpose: This research aimed to explore the clinical efficacy of fecal microbiota transplantation (FMT) in treating children with autism spectrum disorder (ASD).

Methods: In this single-arm prospective study, every participant received FMT therapy, followed by an 8-week follow-up. Children unable to swallow lyophilized capsules (Caps) received fecal solution through transendoscopic enteral tube (TET) or nasal jejunal tube (NJT) approaches.

MMP13 as an effective target of an active trifluoromethyl quinazoline compound against osteosarcoma.

Osteosarcoma (OS) is a highly fatal malignant tumor with a high metastatic rate and poor prognosis. Matrix metalloproteinase-13 (MMP13) is involved in OS metastasis. Its increased expression is closely related to distant metastasis and poor prognosis.

Metaxin-2 tunes mitochondrial transportation and neuronal function in Drosophila.

Metaxins are a family of evolutionarily conserved proteins that reside on the mitochondria outer membrane (MOM) and participate in the protein import into the mitochondria. Metaxin-2 (Mtx2), a member of this family, has been identified as a key component in the machinery for mitochondrial transport in both C. elegans and human neurons.

Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension.

Objective: To investigate the effects of sodium-glucose co-transporter 2 inhibitor dapagliflozin on pulmonary vascular remodeling in a rat model of chronic hypoxic pulmonary arterial hypertension.

Methods: Eighteen female Sprague-Dawley rats were divided into three groups: control (CON), chronic hypoxia (HYP), and chronic hypoxia + dapagliflozin. The HYP and dapagliflozin groups were subjected to hypoxia and received saline or dapagliflozin.

Ultrathin high-entropy hydrotalcites-based injectable hydrogel with programmed bactericidal and anti-inflammatory effects to accelerate drug-resistant bacterial infected wound healing.

Drug-resistant bacteria infected wounds often bring high risks of delayed healing process and even death. Sonodynamic therapy (SDT) can efficiently kill drug-resistant bacteria. However, superabundant reactive oxygen species (ROS) generated during SDT inevitably trigger significant inflammatory responses, hindering tissue remodeling.

A Force-Thermal-Magnetic Trimodal Flexible Sensor for Ultrafine Recognition of Metallic Materials.

Humans possess the remarkable ability to perceive the intricate world by integrating multiple senses. However, the challenge of enabling humanoid robots to achieve multimodal sensing and fine recognition of metallic materials persists. In this study, we propose a flexible tactile sensor that mimics the sensory patterns of human skin, which is assembled by a flexible electromagnetic coil that is engraved on the surface of a polyimide substrate and porous MXene/CNT aerogel.

Effectiveness of a scenario-based, community-based intervention in containing COVID-19 in China.

Background: Given the significant impact of the more than three-year-long COVID-19 pandemic on people's health, social order, and economic performance, as well as the potential re-emergence of a new variant and the epidemic "Disease X," it is crucial to examine its developmental trends and suggest countermeasures to address community epidemics of severe respiratory infectious diseases.

Methods: The epidemiological characterization of various strains of COVID-19 was modeled using an improved Susceptible-Exposed-Infectious-Recovered (SEIR) model to simulate the infections of different strains of COVID-19 under different scenarios, taking as an example an urban area of a prefecture-level city in Shandong Province, China, with a resident population of 2 million. Scenarios 1-5 are scenario-based simulations the Omicron strain, and 6-8 simulate the original COVID-19 strain, with different parameters for each scenario.

A study on lane-changing risk evolution of vehicle group based on potential field model in the freeway tunnel approach section.

Objective: In the freeway tunnel approach section, lane-changing behaviors and transitions in the driving environment exacerbate traffic flow disruptions, increase driving risks, and lead to a higher accident rate. To this end, this study presents a method to explore the risk evolution process of lane-changing in these sections and evaluate its impact on traffic flow operations surrounding lane-changing vehicles.

Methods: First, a driving risk potential field model based on the field theory, which consists of a vehicle kinetic potential field and a tunnel illumination potential field, is proposed to evaluate the driving risk.

AI-driven 3D bioprinting for regenerative medicine: From bench to bedside.

In recent decades, 3D bioprinting has garnered significant research attention due to its ability to manipulate biomaterials and cells to create complex structures precisely. However, due to technological and cost constraints, the clinical translation of 3D bioprinted products (BPPs) from bench to bedside has been hindered by challenges in terms of personalization of design and scaling up of production. Recently, the emerging applications of artificial intelligence (AI) technologies have significantly improved the performance of 3D bioprinting.

MAGI2-AS3 hypermethylated in promoter region promotes migration and invasion of head and neck squamous cell carcinoma via miRNA-31-5p/AR axis.

Molecular regulatory mechanism of MAGI2-AS3 in HNSCC is not yet mature.In this study, we analyzed the methylation level of MAGI2-AS3 promoter and its downstream miR-31-5p/AR axis by bioinformatics methods. qRT-PCR was used to detect the mRNA expression level of each gene, and western blot was used to detect the expression level of AR proteins in tissues and cells.

IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages.

Tumor-associated macrophages (TAMs) are a critical component of the immunosuppressive tumor microenvironment, comprising monocyte-derived macrophages (MDM-TAMs) and tissue-resident macrophages (TRM-TAMs). Here, we discovered that TRM-TAMs mediate the pro-tumor effects of interleukin (IL)-17A and that IL-17A-driven tumor progression requires tumor cell production of osteopontin (OPN). Mechanistically, we identified CEBPβ as a transcription factor downstream of IL-17A in tumor cells and LYVE-1 as an OPN receptor on TRM-TAMs.