Fungal community composition and function in different Chinese post-fermented teas.

Chinese post-fermented teas are produced through special fermentation by microorganisms, with fungi significantly contributing to their flavor and sensory characteristics. Here, the fungal community structure and function were investigated using Illumina HiSeq sequencing of the fungal ITS rDNA region across different post-fermented teas, including Fuzhuan, Qingzhuan, Tianjian black, Liupao, and raw and ripened Pu-erh. Additionally, the headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) technology was used to compare the volatile components of tea samples, and moisture content, pH, total nitrogen, carbon-nitrogen ratio, and total sulfur were measured.

Sphingosinicella rhizophila sp. nov., Isolated from Oat (Avena sativa L.) Rhizosphere Soil.

A Gram-stain-negative, aerobic, rod-shaped, and yellow-colored bacterium, designated strain GR2756, was isolated from a rhizosphere soil sample of oat (Avena sativa L.). The strain GR2756 was able to grow at 15-35 °C, pH 6.

Microstructure, Mechanical Properties, and Corrosion Behavior in Al-5.6Zn-2.5Mg-1.6Cu-0.2Cr Alloy with Minor Yttrium Addition.

This study systematically investigated the effects of the addition of the rare earth element yttrium (Y) on the microstructural evolution, mechanical properties, and corrosion behavior of as-extruded Al-5.6Zn-2.5Mg-1.

ALDH2 Overexpression Improves the Blood-brain Barrier and Represses Mitochondrial Dysfunction in Chronic Cerebral Hypoperfusion Through the SIRT1/ROS Axis.

The study investigated the mechanism of ALDH2 in mitochondrial dysfunction and blood-brain barrier (BBB) damage arising from chronic cerebral hypoperfusion (CCH). A rat model of bilateral common carotid artery occlusion (BCCAO) was established and treated with AAV-ALDH2. ALDH2 expression, cognitive function, and levels of inflammation- and oxidative stress-related factors, were examined, followed by observing changes in BBB and mitochondrial functions.

Magnolin ameliorates acetaminophen-induced liver injury in mice via modulating the MAPK pathway and lipid metabolism.

Acetaminophen (APAP)-induced liver injury (AILI) represents a common yet potentially severe type of drug-induced liver injury with limited available effective therapeutic methods. Magnolin possesses excellent anti-inflammatory and antioxidant properties for treating various diseases. However, its effects against AILI and the fundamental mechanisms still lack comprehensive exploration.

Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation.

Succinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence.

Relationship between secondary metabolites and ecological suitability zones for Eucommia ulmoides.

The quality of Chinese medicinal materials is closely related to the types and contents of their secondary metabolites, while ecological adaptability influences the production of secondary metabolites. Therefore, identifying the relationship between ecological adaptability and secondary metabolites is important for enhancing the quality of Chinese medicinal materials. In this study, we collected 10-year-old Cortex Eucommiae (Eucommia ulmoides, EU) samples from 21 plots in eight provinces which are the primary production areas of EU in central China.

Impact of pre-pregnancy maternal body mass index on neonatal outcomes in twin delivery: A retrospective cohort study.

Objective: This study examined the potential link between maternal pre-pregnancy body mass index (PPBMI) with neonatal outcomes in twin pregnancies.

Methods: This retrospective analysis records of 1,270 women with twin pregnancies, delivered at the Fujian Maternity and Child Health Hospital between 2019 and 2021, were retrospectively analysed. Women were diagnosed as underweight, normal BMI, and overweight/obese according to their PPBMI.

Neonatal outcomes among twins born through assisted reproduction, compared to those born naturally.

The growing prevalence of assisted reproductive technology (ART) is leading to a continuous rise in twin pregnancies. This study assessed the influence of ART on neonatal outcomes of twin pregnancies. Clinical records of twin deliveries at Fujian Maternity and Child Health Hospital between 2019 and 2021 were retrospectively selected and grouped based on the method of conception: ART-conceived and naturally conceived.

Experiences and needs of older patients with stroke in China involved in rehabilitation decision-making: a qualitative study.

Background: Shared decision-making is recommended for stroke rehabilitation. However, the complexity of the rehabilitation modalities exposes patients to decision-making conflicts, exacerbates their disabilities, and diminishes their quality of life. This study aimed to explore the experiences and needs of older patients with stroke in China during rehabilitation decision-making, providing a reference for developing decision-support strategies.

Identification and validation of autophagy-related genes in Hirschsprung's disease.

Background: Hirschsprung's disease (HSCR) is a congenital disorder characterized by aganglionosis in the intermuscular and submucosal nerve plexuses of the gut, leading to impaired gastrointestinal function. Although the precise cause and pathophysiology of HSCR remain elusive, increasing evidence points to a significant role of autophagy in its development, warranting further investigation into its underlying mechanisms.

Methods: This study utilized publicly available microarray expression profiling datasets, GSE96854 and GSE98502, from the Gene Expression Omnibus (GEO).

Kernel Masked Image Modeling Through the Lens of Theoretical Understanding.

Masked image modeling (MIM) has been considered as the state-of-the-art (SOTA) self-supervised learning (SSL) technique in terms of visual pretraining. The impressive generalization ability of MIM also paves the way for the remarkable success of large-scale vision foundation models. In this article, we further discuss the validity and advantages of implementing MIM techniques in the reproducing kernel Hilbert spaces (RKHSs) and we associate the analysis with a novel MIM method named R-MIM (short for RKHS-MIM).

Ultrasound probe enhanced enzymatic hydrolysis for rapid separation of β-adrenergic agonists from animal urine and livestock wastewater: Applicability to biomonitoring investigation.

Background: An increasing number of β-adrenergic agonists are illicitly used for growth promoting and lean meat increasing in animal husbandry in recent years, but the development of analytical methods has lagged behind these emerging drugs.

Results: Here, we designed and developed an ultrasound probe enhanced enzymatic hydrolysis reactor for quick separation and simultaneously quantification of 22 β-adrenergic agonists in animal urine and livestock wastewater. Owing to the enhancement of the conventional enzymatic digestion through the ultrasound acoustic probe power, only 2 min was required for the comprehensively separation of β-adrenergic agonists from the sample matrices, making it a much more desirable alternative tool for high-throughput investigation.

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Disease: Success Rate and Complications among Different Patient Populations.

Introduction: Balloon pulmonary angioplasty (BPA) is an effective intervention for patients with chronic thromboembolic pulmonary disease (CTEPD). We aimed to identify the patient group with a low success rate or high complication rate of BPA, which is still unclear.

Methods: Both CTEPD patients with or without pulmonary hypertension (CTEPH and NoPH-CTEPD) were included.

Machine learning-derived prognostic signature for progression-free survival in non-metastatic nasopharyngeal carcinoma.

Background: Early detection of high-risk nasopharyngeal carcinoma (NPC) recurrence is essential. We created a machine learning-derived prognostic signature (MLDPS) by combining three machine learning (ML) models to predict progression-free survival (PFS) in patients with non-metastatic NPC.

Methods: A cohort of 653 patients with non-metastatic NPC was divided into a training (n = 457) and validation (n = 196) dataset (7:3 ratio).

Oxylipin profiling analyses reveal that ω-3 PUFA is more susceptible to lipid oxidation in sheep testis under oxidative stress.

Reactive oxygen species causes oxidative stress, which oxidizes polyunsaturated fatty acids (PUFAs) to form oxidative metabolites. Sertoli cell is an important cellular metabolism of PUFA in testicular cells, and it regulates the testis development and spermatogenesis. However, the oxylipins generated in testes with different developmental statuses are lacking.

Alleviates Acetaminophen-Induced Hepatotoxicity by Regulating Phenylalanine Metabolism.

Acetaminophen (APAP)-induced liver injury (AILI), even liver failure, is a significant challenge due to the limited availability of therapeutic medicine. () as a probiotic therapy, has shown promising prospects in metabolism and inflammatory diseases. Our research aimed to examine the influence of on AILI and explore the molecular pathways underlying it.

Teaching Masked Autoencoder With Strong Augmentations.

Masked autoencoder (MAE) has been regarded as a capable self-supervised learner for various downstream tasks. Nevertheless, the model still lacks high-level discriminability, which results in poor linear probing performance. In view of the fact that strong augmentation plays an essential role in contrastive learning, can we capitalize on strong augmentation in MAE? The difficulty originates from the pixel uncertainty caused by strong augmentation that may affect the reconstruction, and thus, directly introducing strong augmentation into MAE often hurts the performance.

The mechanism of Sangdantongluo granule in treating post-stroke spasticity based on multimodal fMRI combined with TMS: Study protocol.

Introduction: Post-stroke spasticity (PSS) is among the prevalent complications of stroke, greatly affecting motor function recovery and reducing patients' quality of life without timely treatment. Sangdantongluo granule, a modern traditional Chinese patent medicine, has significant clinical efficacy in treating PSS. However, the mechanism of Sangdantongluo granule in treating PSS is still unknown.

Enhancing C product selectivity in CO electroreduction by enriching intermediates over carbon-based nanoreactors.

Electrochemical CO reduction reaction (CORR) to multicarbon (C) products faces challenges of unsatisfactory selectivity and stability. Guided by finite element method (FEM) simulation, a nanoreactor with cavity structure can facilitate C-C coupling by enriching *CO intermediates, thus enhancing the selectivity of C products. We designed a stable carbon-based nanoreactor with cavity structure and Cu active sites.

Two-component system RstAB promotes the pathogenicity of adherent-invasive in response to acidic conditions within macrophages.

Adherent-invasive (AIEC) strain LF82, isolated from patients with Crohn's disease, invades gut epithelial cells, and replicates in macrophages contributing to chronic inflammation. In this study, we found that RstAB contributing to the colonization of LF82 in a mouse model of chronic colitis by promoting bacterial replication in macrophages. By comparing the transcriptomes of mutant- and wild-type when infected macrophages, 83 significant differentially expressed genes in LF82 were identified.