Comparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients.

Objective: This study aimed to explore differences in clinical symptom profiles and symptom network structures of inpatients with schizophrenia among early-onset schizophrenia (EOS), typical-onset schizophrenia (TOS), and late-onset schizophrenia (LOS) patients.

Methods: Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS) in 654 EOS, 1664 TOS, and 369 LOS inpatients with schizophrenia from an open dataset. Symptom severity comparisons were conducted among the three age of onset groups.

Protective effects of dietary supplementation of Bacillus Subtilis MZ18 against the reproductive toxicity of zearalenone in pregnant rats.

The microbial detoxification method demonstrates significant potential for detoxifying feed contaminated with mycotoxins, but the application of degrading bacteria in mammals was rarely investigated. In this study, the effects of dietary zearalenone on the growth performance, reproductive performance, reproductive organs, hormone levels of rats and the toxicity alleviation of Bacillus subtilis MZ18 were studied. From gestation day 0-20, pregnant SD rats received either a normal diet or a diet supplemented with zearalenone at a dose of 20 mg/kg⋅BW, and with or without supplementation of Bacillus subtilis MZ18 culture.

Hypoxia tolerance and physiological coping strategies in fat greenling (Hexagrammos otakii).

Dissolved oxygen (DO) is necessary for fish survival and growth. This study investigated the hypoxia tolerance, hematological indexes, hepatic antioxidant capacity, and liver and gill morphological alternation of fat greenling during hypoxia stress. Changes in hematological parameters (cortisol, glucose, lactic acid, hemoglobin [Hb], hematocrit [Hct], and white blood cell [WBC], and red blood cell [RBC] numbers), hepatic antioxidant enzymes (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], catalase [CAT]), aminotransferase (AST), alanine aminotransferase (ALT) activities, and malondialdehyde (MDA) contents, and the histology of the liver and gill were evaluated under hypoxia stress and reoxygenation.

Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation.

Background: Immune rejection represents a significant barrier to transplantation, especially in the context of xenotransplantation. Endothelial cells (ECs) derived from pigs serve as the initial barrier against the human immune system in xenotransplantation. Tight junction proteins are essential components of endothelial cell tight junctions; however, their role in xenotransplantation has been less thoroughly investigated.

Elav/hu RNA-Binding protein family: key regulators in neurological disorders, cancer, and other diseases.

The ELAV/Hu family represents a crucial group of RNA-binding proteins predominantly expressed in neurons, playing significant roles in mRNA transcription and translation. These proteins bind to AU-rich elements in transcripts to regulate the expression of cytokines, growth factors, and the development and maintenance of neurons. Elav-like RNA-binding proteins exhibit remarkable molecular weight conservation across different species, highlighting their evolutionary conservation.

Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.

Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension.

Bromide accelerates oxidation of selenite by unactivated peroxymonosulfate: PH-dependent kinetics, mechanism and pathways.

Selenium (Se) is an essential trace element that is toxic to humans in a relatively small excess. In natural waters it occurs mainly in inorganic form as Se(IV) and Se(VI) oxyanions with the former being more toxic at high levels. With the increasing use of advanced oxidation processes in drinking water treatment, the oxidation of Se(IV) with unactivated peroxymonosulfate (PMS) has been investigated, but the role of bromide (Br) on the oxidation of Se(IV) during reaction with unactivated PMS remains unknown.

Evaluation of the effects on the tensile properties of medical gloves after repeated disinfection.

This study was aimed to explore the effects of the disinfectants commonly used in the hospitals on the tensile properties of the medical gloves with the different materials. Three types of medical gloves, composed of latex, nitrile, and polyvinyl chloride (PVC), were exposed to common chemical disinfectants to analyze the effects on the tensile properties. Ethanol-based hand rub(EBHR) and chlorine antiseptic were selected for testing.

Cardiovascular toxicities of hypoxia-inducible factor prolyl hydroxylase inhibitors: a disproportionality analysis based on JADER database.

Background: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have shown promising prospects as novel therapeutic agents in renal anemia, but their potential cardiovascular toxicities have raised widespread concern. This study aim to explore the cardiovascular toxicities associated with HIF-PHIs through real-world long-term safety data.

Research Design And Methods: A disproportionality analysis was employed by calculating the reporting odds ratios (ROR), information component (IC), and their 95% credibility intervals (CrI) in Japan Adverse Drug Event Report (JADER) database from 1 January 2020, to 30 September 2023.

Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis.

Adult skeletal muscle stem cells (MuSCs) are indispensable for muscle regeneration and tightly regulated by macrophages (MPs) and fibro-adipogenic progenitors (FAPs) in their niche. Deregulated MuSC/MP/FAP interactions and the ensuing inflammation and fibrosis are hallmarks of dystrophic muscle. Here we demonstrate intrinsic deletion of transcription factor Yin Yang 1 (YY1) in MuSCs exacerbates dystrophic pathologies by altering composition and heterogeneity of MPs and FAPs.

Optimal dose and type of exercise to improve motor symptoms in adults with Parkinson's disease: A network meta-analysis.

Objectives: This study aimed to evaluate the dose-response relationship between different exercise types and the alleviation of motor symptoms in Parkinson's Disease patients.

Design: A systematic review and network meta-analysis were conducted to compare the effects of 12 exercise types on motor symptoms in Parkinson's Disease patients using randomized controlled trials.

Methods: A systematic search was conducted across PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science until September 10, 2024.

Association between moderate-to-vigorous physical activity trajectories and academic achievement in Chinese primary school children: a 3-year longitudinal study.

Background: Past cross-sectional studies have reported a positive association between moderate-to-vigorous physical activity (MVPA) and academic achievement in children and adolescents. Despite this, the influence of variations in MVPA over time on academic achievement remains yet to be definitively understood. Therefore, this study aims to track the patterns of MVPA and examine how they are associated with academic achievement over a three-year period among Chinese primary school students.

Directed Evolution of Microbial Communities in Fermented Foods: Strategies, Mechanisms, and Challenges.

Directed Evolution of Microbial Communities (DEMC) offers a promising approach to enhance the functional attributes of microbial consortia in fermented foods by mimicking natural selection processes. This review details the application of DEMC in fermented foods, focusing on optimizing community traits to improve both fermentation efficiency and the sensory quality of the final products. We outline the core techniques used in DEMC, including the strategic construction of initial microbial communities, the systematic introduction of stress factors to induce desirable traits, and the use of artificial selection to cultivate superior communities.

A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment.

With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and targeted therapy. However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms.

Modulation pattern recognition method of wireless communication automatic system based on IABLN algorithm in intelligent system.

The aim of this study is to address the limitations of convolutional networks in recognizing modulation patterns. These networks are unable to utilize temporal information effectively for feature extraction and modulation pattern recognition, resulting in inefficient modulation pattern recognition. To address this issue, a signal modulation recognition method based on a two-way interactive temporal attention network algorithm has been developed.

Identification of novel CDH23 heterozygous variants causing autosomal recessive nonsyndromic hearing loss.

Background: Hearing loss adversely impacts language development, acquisition, and the social and cognitive maturation of affected children. The hearing loss etiology mainly includes genetic factors and environmental factors, of which the former account for about 50-60%.

Objective: This study aimed to investigate the genetic basis of autosomal recessive non-syndromic hearing loss (NSHL) by identifying and characterizing novel variants in the CDH23 gene.

Trend analysis and cross nations inequality analysis of infectious skin diseases from 1990 to 2021.

The skin serves as a crucial barrier against microbial invasion, but breaches in this barrier can lead to infectious skin diseases (ISD). ISD, including bacterial (BSD), fungal (FSD) and viral Skin Disease (VSD), pose significant global health challenges. Age-standardized and age specific incidence, prevalence, and lived with disability (YLDs) data for ISD were sourced from the Global Burden of Disease Study 2021 (GBD 2021) and demographic data from the United Nations.

Water Disinfection with Dual-Wavelength (222 + 275 nm) Ultraviolet Radiations: Microbial Inactivation and Reactivation.

Emerging mercury-free ultraviolet (UV) sources, such as krypton chloride excimer (KrCl*) lamps and UV light emitting diodes (UV-LEDs), emit diverse wavelengths with distinct inactivation mechanisms. The combined application has the potential to improve disinfection effectiveness through synergism. In this study, a mini-fluidic photoreaction system equipped with a KrCl* lamp (222 nm) and a strip of UV-LEDs (275 nm) was developed, which could individually/simultaneously deliver accurate UV radiation(s) at 222 nm (0.

Association between tinnitus and hearing impairment among older adults with age-related hearing loss: a multi-center cross-sectional study.

Objective: The relationship between tinnitus in the elderly with hearing loss remains elusive. This study aimed to reveal the association between tinnitus and hearing impairment among older adults with age-related hearing loss (ARHL).

Methods: This cross-sectional study was conducted among a population of outpatients diagnosed with ARHL at four medical centers in different regions of China, from June 2020 to June 2023.

Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy.

Background: Metagenomic next-generation sequencing (mNGS) is an effective method for detecting pathogenic pathogens of bloodstream infection (BSI). However, there is no consensus on whether the use of antibiotics affects the diagnostic performance of mNGS. We conducted a prospective clinical study aiming to evaluate the effect of antimicrobial treatment on mNGS.

Nanoscale Liposomes Co-Loaded with Irinotecan Hydrochloride and Thalidomide for Colorectal Cancer Synergistic Therapy.

Irinotecan hydrochloride (CPT-11) is one of the first-line drugs used in the clinical treatment of colorectal cancer (CRC). However, the concomitant adverse effect of delayed diarrhea has hindered its clinical use. CPT-11 combined with Thalidomide (THA) therapy is considered a palliative strategy.

MWFormer: Estimation of Molecular Weights from Electron Ionization Mass Spectra for Improved Library Searching.

Molecular weight (MW) is a crucial property to improve the accuracy of multidimensional compound identification. In this study, we have developed MWFormer, a novel method that predicts MWs solely from spectra of electron ionization mass spectrometry (EI-MS) based on a Transformer encoder. MWFormer achieves a mean absolute error (MAE) of 6.

Transcriptomics profiling of the non-small cell lung cancer microenvironment across disease stages reveals dual immune cell-type behaviors.

Background: Lung cancer is the leading cause of cancer death worldwide, with poor survival despite recent therapeutic advances. A better understanding of the complexity of the tumor microenvironment is needed to improve patients' outcome.

Methods: We applied a computational immunology approach (involving immune cell proportion estimation by deconvolution, transcription factor activity inference, pathways and immune scores estimations) in order to characterize bulk transcriptomics of 62 primary lung adenocarcinoma (LUAD) samples from patients across disease stages.

The safe lowest effective power of subthreshold micropulse laser treatment in Chinese patients with acute or chronic central serous chorioretinopathy.

Purpose: To assess the safe, lowest effective laser power of subthreshold micropulse laser (SML) for treating acute and chronic central serous chorioretinopathy (CSC) in Chinese patients.

Methods: Patients were distinguished with acute or chronic CSC based on focal or diffuse retinal pigment epithelium (RPE) leakage on fundus fluorescein angiography (FFA), with or without widespread RPE decompensation. Patients were categorized into five groups and treated with 577 nm yellow SML according to 50% titration power.