Acute retinal necrosis following cataract surgery: a case of VZV reactivation and successful management.

Background: Acute retinal necrosis triggered by routine cataract surgery is a rare condition, which may be overlooked by the clinicians. We report a case of unilateral acute retinal necrosis (ARN) with the onset 4 days after uncomplicated cataract surgery. The patient demonstrates satisfactory outcomes following anti-virus therapy.

Association between C-reactive protein and hemoglobin in US rheumatoid arthritis patients based on NHANES data analysis.

The poor prognosis of rheumatoid arthritis (RA) and its potential for complications highlight the importance of understanding factors that are associated with incidence and mortality rates. The inclusion criteria of this study were RA-related data from 1999 to 2018 in the National Health and Nutrition Examination Survey (NHANES) dataset. Based on certain screening criteria, a total of 610 subjects were recruited.

Identification of candidate biomarkers correlated with the pathogenesis of breast cancer patients.

Breast cancer (BC) is the second leading cause of cancer-related death in females, followed by lung cancer. Disadvantages exist in conventional diagnostic techniques of BC, such as radiation risk. The present study integrated bioinformatics analysis with machine learning to elucidate potential key candidate genes associated with the tumorigenesis of BC.

The molecular mechanism of ginsenoside Rh2 and its octyl ester derivative on anti-angiogenesis in cancer treatment: The battle between PI3K and ROS.

Background: The cancer treatments that target tumor associated angiogenesis (TAA) induced by vascular endothelial growth factor A (VEGFA) have become valued. Ginsenoside Rh2 has been proved to inhibit TAA through VEGFA. However, the underlying mechanisms remain unclear.

Periodontitis and gastrointestinal cancer: a nationwide cohort study of NHANES 2009-2014.

Unlabelled: The association between periodontitis and gastrointestinal tract (GIT) cancer has undergone extensive investigation. However, there is ongoing controversy regarding the impact of periodontitis on the incidence and mortality rates among GIT cancer patients. This study aims to clarify the relationship between periodontitis and the risk as well as mortality rates of GIT cancer.

Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma.

Background: Neuroblastoma (NB) is the most common solid tumor in children, characterized by high recurrence rates, drug resistance, and significant mortality.

Methods: In this study, we analyzed the proteomic profiles of NB tissue samples alongside other pathological categories, including ganglioneuroma (GN) and ganglioneuroblastoma (GNB). Using weighted gene co-expression network analysis (WGCNA), the core prognostic gene models associated with histopathology of NB were identified.

Irisin-mediated muscle-renal crosstalk as a protective mechanism against contrast-induced acute kidney injury via cGAS-STING signalling inhibition.

Background: Contrast-induced acute kidney injury (CI-AKI) continues to pose a pressing clinical challenge during invasive cardiovascular procedures due to the limited availability of preventative strategies. We aimed to demonstrate that irisin, a myokine induced by exercise, protects against CI-AKI by inhibiting the cGAS-STING inflammatory pathway.

Methods And Results: We explored the relationship between serum irisin levels and CI-AKI incidence in patients administered the contrast media iohexol.

Characterization of Microbial Carbon Metabolism in Karst Soils from Citrus Orchards and Analysis of Its Environmental Drivers.

Karst regions (KRs) have created significant karst carbon sinks globally through the carbon cycling process involving "water-carbon dioxide-carbonate rock-biota". Soil organic carbon (SOC) represents a crucial component of these carbon sinks. Microorganisms play a vital role in the soil carbon cycle, influencing the formation and preservation of SOC.

Classical Swine Fever Virus Envelope Glycoproteins E, E1, and E2 Activate IL-10-STAT1-MX1/OAS1 Antiviral Pathway via Replacing Classical IFNα/β.

Classical swine fever (CSF) is an acute and often fatal disease caused by CSF virus (CSFV) infection. In the present study, we investigated the transcriptional profiles of peripheral blood mononuclear cells (PBMCs) in pigs infected with CSFV. The results revealed that CSFV inhibits IFNα/β production, but up-regulates the expression of signal transducer and activator of transcription 1 (STAT1); this result was verified in vitro.

Prediction of survival in acute myeloid leukemia patients by extracellular to intracellular water ratio and sarcopenia: development and validation of a novel nomogram.

Acute myeloid leukemia (AML) commonly affects the elderly with a poor prognosis. Body water composition analysis provides a new perspective for biomedical research. This study aims to develop and validate a simple nomogram for predicting overall survival (OS) in AML survivors.

The application of contrast-enhanced ultrasound and MicroFlow Imaging in the diagnosis of breast cancer.

Purpose: The purpose of this study was to compare the value of contrast-enhanced ultrasound (CEUS) plus MicroFlow Imaging (CEUS-MFI), MicroFlow Imaging (MFI) alone, and color Doppler flow imaging (CDFI) in the differential diagnosis of benign and malignant breast lesions.

Methods: A total of 116 patients with 116 breast lesions categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4 were enrolled in this prospective study. CEUS-MFI, MFI, and CDFI were used to evaluate the microvascular morphology and distribution types of breast lesions.

Design of Self-Storage and Tremella-like MoS Lubricant Induced by Laser Irradiation for Achieving Stable Ultralow Friction in Atmosphere.

Molybdenum disulfide (MoS) has a typical layered structure and is widely used in the lubrication field. However, its nanosheets are difficult to disperse and prone to agglomeration in lubricating oil, which makes it challenging to achieve ultralow friction in the atmospheric environment and restricts its practical applications. Therefore, it is of great significance to solve the disperse and agglomeration problems of MoS to realize ultralow friction.

Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis.

Background: Patients with duchenne muscular dystrophy (DMD) have an increased risk of complications when they undergo sedation or general anesthesia. However, due to improvements in cardiopulmonary therapies during anesthetic care, patients with DMD are experiencing an unprecedented duration of survival. We performed a systematic analysis to assess the benefits and risks of pharmacological interventions for the management of anesthesia and sedation in DMD patients.

Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA.

Purpose: This study aims to investigate microvascular changes in the macular and peripheral regions, as well as alterations in the foveal avascular zone (FAZ) of the ipsilateral eye using widefield swept-source optical coherence tomography angiography (SS-OCTA) in patients with severe carotid artery stenosis (SCAS) after carotid artery revascularization (CAR).

Design: This study employed a prospective study design.

Methods: SCAS patients were examined using widefield SS-OCTA, which covered an area of 16 × 16 mm centered on the fovea.

The effects of maternal health literacy, family functioning and self-efficacy on antepartum depression in pregnant women in China: a moderated mediation model.

Background: Antepartum depression (AD) is associated with a greater risk of adverse outcomes for both mothers and fetuses. Maternal health literacy (MHL), family functioning (FF), and self-efficacy (SE) are important factors affecting antepartum depression (AD) in pregnant women. Therefore, this study aimed to explore the associations between these factors and whether MHL and SE mediate the relationship between FF and AD.

Ultrasensitive sulphide detecting by using Au (core)-Ag (shell) triangular nanoprisms.

Hydrogen sulfide (HS), the third endogenous gaseous molecule, plays a crucial role in biological signaling and metabolic processes. It has garnered significant attention from researchers in the field of biochemistry. The highly sensitive detection of HS is essential for elucidating its functions and has long been a key objective in biochemical sensing.

Arsenic mobility and microbial community composition in the sediments of coastal wetlands driven by tidal action.

Arsenic (As) pollution in coastal wetlands has been receiving growing attention. However, the exact mechanism of As mobility driven by tidal action is still not completely understood. The results reveal that lower total As concentrations in solution were observed in the flood-ebb treatment (FE), with the highest concentration being 7.

Safety, tolerability, pharmacokinetic, and pharmacodynamic of CZ1S injection for unilateral brachial plexus blockade in healthy Chinese adults: Double-blind, randomized, positive-controlled Phase I study.

CZ1S injection is a novel, extended-release local anaesthetic formulation of ropivacaine, classified as a type 2.2 new drug, with potential for post-operative analgesia by subcutaneous infiltration and peripheral nerve blockade. This study aimed to validate the superior properties of CZ1S over ropivacaine hydrochloride injection and to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) profiles of a single dose of brachial plexus block with CZ1S in healthy Chinese adults.

Designing superoxide-responsive near-infrared afterglow materials for enhanced arthritis imaging.

Here we report an afterglow material, APT/TTQNPs. This material can be activated by superoxide anions (O˙) to emit NIR afterglow. APT/TTQNPs possess high selectivity, high sensitivity, and high imaging signal-to-noise ratio to O˙.

The Value of LC-MS/MS in Apparent Bilateral Aldosterone Suppression in Adrenal Venous Sampling for Primary Aldosteronism.

Context: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA), however, it is unreliable when apparent bilateral aldosterone suppression (ABAS) occurs, defined as aldosterone/cortisol ratio in the adrenal vein being bilaterally lower than that in the inferior vena cava. The value of Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in PA subtyping when ABAS occurs is unclear.

Objective: To determine whether LC-MS/MS can reduce the occurrence of ABAS and misdiagnosis of PA subtyping.

Relationship Between Sexual Function, Health-Promoting Behaviors, and Quality of Life in Female Patients With Pulmonary Arterial Hypertension.

Pulmonary arterial hypertension (PAH) is a chronic progressive exacerbation of cardiopulmonary vascular disease. The patients' exercise endurance decreased progressively and the survival rate was low. Current basic therapy and targeted drug therapy can improve the quality of life (QoL) of PAH patients, but the long-term efficacy and prognosis are not good.

Preparation of Low-Fishy Microencapsulated DHA-Rich Algal Oil Powder Using Infant Rice Powder.

Commercial DHA-rich algal oil has some issues, such as an unpleasant odor and susceptibility to oxidation. The main fishy odor compounds in commercial DHA-rich algal oil powder and DHA-rich algal oil microcapsules are hexanal and (E, E)-2,4-heptadienal. To address this issue, a microencapsulation process was designed for DHA-rich algal oil using infant rice powder (IRP), maltodextrin (MD), and whey protein concentrate (WPC) as wall materials, with sodium starch octenyl succinate (SSOS) and monoacylglycerol (MAC) as emulsifiers.

A preliminary study on the diagnostic value of contrast-enhanced ultrasound and micro-flow imaging for detecting blood flow signals in breast cancer patients.

Background: The distribution and morphology of mass microvessels could affect the diagnostic accuracy of breast cancer (BC). The aim of our study was to compare the value of contrast-enhanced ultrasound and micro-flow imaging (CEUS-MFI), contrast-enhanced ultrasound (CEUS), and color Doppler flow imaging (CDFI) in the assessment of mass microvasculature.

Methods: A total of 106 patients with 106 breast masses categorized as Breast Imaging Reporting and Data System (BI-RADS) category 4 were enrolled in our prospective study.

Seeing the unseen: NIR probes for reactive nitrogen species biosensing and bioimaging.

Reactive nitrogen species (RNS) play a crucial role in both health and disease, making their accurate and sensitive detection essential. However, their transient nature (∼milliseconds), high reactivity, and low abundance (nM-μM) in complex biological environments present significant challenges. Near-infrared (NIR) fluorescent probes have emerged as a promising solution for in vivo RNS imaging due to their enhanced sensitivity, spatiotemporal resolution, and deep tissue penetration.