Hemoglobin concentrations in early pregnancy and their associations with adverse pregnancy outcomes in Western China: a population-based study.

Background: Despite the global standardization of hemoglobin (Hb) testing in early pregnancy, the impact of first trimester Hb concentrations on pregnancy outcomes remains inadequately understood. Also, the early pregnancy Hb concentrations have not been well documented in Western China. Therefore, this study aimed to assess the Hb concentrations during early pregnancy and their associations with adverse pregnancy outcomes in Western China.

Transcriptome and targeted metabolome analysis of lipid profiles, nutrients compositions and volatile compounds in longissimus dorsi of different pig breeds.

Objective: Improving meat quality is important for commercial production and breeding. The molecular mechanism of intramuscular fat (IMF) deposition and meat characteristics remain further study.

Methods: This study aimed to study the mechanism of IMF deposition and meat characteristics including redox potential, nutrients compositions and volatile compounds in longissimus dorsi (LD) by comparing with different pig breeds including Shanghai white (SW), Duroc x (Landrace Yorkshire) (DLY) and Laiwu (LW) pigs.

Female urinary incontinence in China after 15 years' efforts: Results from large-scale nationwide surveys.

Urinary incontinence (UI) is a disease that quietly yet seriously impacts women's health and represents a global health burden that is often neglected. This study aims to systematically assess the prevalence and dynamics of female UI in China, and can inform further policies and have international implications. This study used three nationwide investigations: A national cross-sectional survey in 2021; another nationwide cross-sectional survey in 2006; and data regarding the institutions and physicians providing pelvic floor rehabilitation services from 2005 to 2019.

An oil-in-gel type of organohydrogel loaded with methylprednisolone for the treatment of secondary injuries following spinal cord traumas.

The secondary injuries following traumatic spinal cord injury (SCI) is a multiphasic and complex process that is difficult to treat. Although methylprednisolone (MP) is the only available pharmacological regime for SCI treatment, its efficacy remains controversial due to its very narrow therapeutic time window and safety concerns associated with high dosage. In this study, we have developed an oil-in-gel type of organohydrogel (OHG) in which the binary oleic-water phases coexist, for the local delivery of MP.

Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study.

Background: The effect of combining prone ventilation with traditional Chinese medicine on severe pneumonia remains unclear.

Objective: To evaluate the effect of Fu Zheng Jie Du Formula (FZJDF) combined with prone ventilation on clinical outcomes in patients with severe pneumonia.

Methods: This single-center retrospective cohort study included 188 severe pneumonia patients admitted to the ICU from January 2022 to December 2023.

[Effect of Intrauterine Perfusion of Granulocyte Colony-Stimulating Factor on Endometrium and Blood Flow Parameters in Patients With Thin Endometrium: A Prospective Controlled Clinical Trial].

Objective: To investigate the effects of intrauterine perfusion with granulocyte colony-stimulating factor (G-CSF) on the endometrial thickness, volume, and blood flow parameters of patients with thin endometrium and their clinical outcomes.

Methods: We designed a prospective non-randomized synchronous controlled trial and recruited patients with thin endometrium who underwent frozen-thawed embryo transfer (FET) at Mianyang Central Hospital between September 1, 2021 and September 1, 2023. They were divided into two groups, an experimental group of patients who received the experimental treatment of intrauterine perfusion with G-CSF and a control group of patients who did not receive the experimental treatment.

Microbe-Derived Antioxidants Protect IPEC-1 Cells from HO-Induced Oxidative Stress, Inflammation and Tight Junction Protein Disruption via Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway.

Oxidative stress can induce inflammation and tight junction disruption in enterocytes. The initiation of inflammation is thought to commence with the activation of the ROS/NLRP3/IL-1β signaling pathway, marking a crucial starting point in the process. In our previous studies, we found that microbe-derived antioxidants (MAs) showed significant potential in enhancing both antioxidant capabilities and anti-inflammatory effects.

Advances in cellular and molecular predatory biology of six decades after discovery.

Since its discovery six decades ago, the predatory bacterium has sparked recent interest as a potential remedy to the antibiotic resistance crisis. Here we give a comprehensive historical overview from discovery to progressive developments in microscopy and molecular mechanisms. Research on has moved from curiosity to a new model organism, revealing over time more details on its physiology and fascinating predatory life cycle with the help of a variety of methods.

Preparation of a Microwave-Absorbing UV Coating Using a BaFeO-Polypyrrole Nanocomposite Filler.

BaFeO-polypyrrolenanocomposites were prepared via the in situ chemical oxidative polymerization of pyrrole monomers in the presence of BaFeO powder, with ammonium persulfate as an oxidant and sodium dodecyl benzene sulfonate as a dopant. X-ray diffraction measurements and Fourier-transform infrared spectroscopy indicated that there were no chemical interactions between BaFeO and polypyrrole. In addition, scanning electron microscopy showed that the composites exhibited a core-shell structure.

Changes in behavior patterns or demographic structure? Re-estimating the impact of higher education on the average age of the first marriage.

During the last few decades, China implemented college enrollment expansion to accelerate the process of urbanization. However, most existing papers blaming that receiving higher education may delay people choosing to enter the age of first marriage, which in turn results in the age of the population. In this paper, we argued that the previous papers confused the total impact of higher education on the average age of the first marriage with the influence on individual's behavior change, and thus led to overestimating the delayed effect of higher education on the age choosing behavior of first marriage.

Preparation of UV-Curable Nano-WOCoating and Its Infrared Shielding Properties.

Nano-WO particles are expected to find use in new shielding materials because of their significant absorption of near-infrared light in the 1400-1600 nm and 1900-2200 nm bands and high transmittance of visible light. In this study, WO was ground and dispersed using high-energy ball-milling to prepare a nano-WO dispersion using BYK331 as the dispersant and ethanol as the solvent. The prepared nano-WO dispersion was added to a photo-curing system and cured using UV irradiation to form films.

A facile method for anti-cancer drug encapsulation into polymersomes with a core-satellite structure.

Polymersomes possess the self-assembly vesicular structure similar to liposomes. Although a variety of comparisons between polymersomes and liposomes in the aspects of physical properties, preparation and applications have been elaborated in many studies, few focus on their differences in drug encapsulation, delivery and release and In the present work, we have provided a modified direct hydration method to encapsulate anti-cancer drug paclitaxel (PTX) into PEG--PCL constituted polymersomes (PTX@PS). In addition to advantages including narrow particle size distribution, high colloid stability and moderate drug-loading efficiency, we find that the loaded drug aggregate in small clusters and reside through the polymersome membrane, representing a unique core-satellite structure which might facilitate the sustained drug release.

Inhibitory Effect of Fermented Polysaccharides on Mice Intestinal Inflammation.

To investigate the effect of polysaccharides (FVPs) on mice intestinal inflammation, FVPs were extracted from (FV) using a solid anaerobic fermentation technique. The antioxidant and anti-inflammatory capacities of FVP and fermented FVP (FFVP) induced by lipopolysaccharide (LPS) were investigated and . The results showed that the yield of FFVP (9.

The Influence of Parental Educational Expectations on Children's Higher Education Attainment: Re-estimation Based on Instrumental Variables.

Studies show that parental educational expectations (PEEs) serve as an intermediary variable between family background and children's educational attainment. This paper re-examines the relationship between PEEs and children's higher educational attainment using data from the China Family Panel Studies (CFPS) 2010-2018. To address potential endogenous problems in the previous papers, we use the average College Enrolment Opportunity Index (CEOI) when the children were 10-12 years old as an instrumental variable for PEEs.

Recognition of Gonadal Development in Based on the Impulse of Love at First Sight.

Given the difficulty in identifying individuals with different degrees of ovarian development, we developed a new device utilizing the hypothesis of mutual attraction behavior between male and female crabs with mature gonads by releasing the sexual pheromone so they could be examined. From a total of 40 female crabs, 10 were isolated within half an hour. Histological analysis showed that the ovaries of crabs in the isolated group were in stage IV, while those of the control groups were in stage III.

Predicting EGFR mutation status in lung adenocarcinoma presenting as ground-glass opacity: utilizing radiomics model in clinical translation.

Objectives: This study aimed to establish a non-invasive radiomics model based on computed tomography (CT), with favorable sensitivity and specificity to predict EGFR mutation status in GGO-featured lung adenocarcinoma subsequently guiding the administration of targeted therapy.

Methods: Clinical-pathological information and preoperative CT images of 636 lung adenocarcinoma patients (464, 100, and 72 in the training, internal, and external validation sets, respectively) that underwent GGO lesions resection were included. A total of 1476 radiomics features were extracted with gradient boosting decision tree (GBDT).

Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial.

Background: The stability of hemodynamics during anesthesia induction in patients undergoing valve replacement surgery is particularly important. Remimazolam is a new type of benzodiazepine drug, with supposed advantages of rapid induction, rapid recovery, stable hemodynamics, and mild respiratory inhibition.

Aim: To evaluate the effect of remimazolam anesthesia induction on hemodynamics in patients undergoing valve replacement surgery.

The Prevention and Control Experience of Maternal Health Care from Chengu, China During the COVID-19 Epidemic.

Four months after the first case of COVID-19 was diagnosed in Wuhan, the national epidemic has been effectively controlled in China. In Chengdu, the capital city of Sichuan Province, several management measures, which have been proven to be effective, are taken to prevent pregnant women from being infected with COVID-19. Firstly, Chengdu formulated and issued the "Working Opinions on the Management of Maternal Women during the Epidemic Period of COVID-19 Infection" immediately after the outbreak.

Germanium Hydride Radical Trapped during the Photolysis/Thermolysis of Diarylgermylene.

Herein, we report the characterization of a novel germanium hydride radical arising from the photolysis/thermolysis of the diarylgermylene GeR [R = terphenyl: Ar = CH-2,6-(CH-2,6-Pr) or Ar = CH-2,6-(CH-2,4,6-Pr)] by using electron paramagnetic resonance spectroscopy complemented with theoretical calculations. The trapped germanium radical is a pseudoplanar = / germanium(III) hydride, i.e.

Reversible Sn-Sn Triple Bond Dissociation in a Distannyne: Support for Charge-Shift Bonding Character.

The tin-tin triple bond in the distannyne ArSnSnAr, Ar = CH-2,6(CH-2,6-Pr), undergoes reversible cleavage in deuterated toluene to afford two :SṅAr radicals in solution as shown by H nuclear magnetic resonance and electron paramagnetic resonance spectroscopy. Variable temperature data afforded an enthalpy of dissociation of Δ = 17.2 ± 1.

Acaricidal Mechanism of Scopoletin Against .

Scopoletin is a promising acaricidal botanical natural compound against , and its acaricidal mechanism maybe involve calcium overload according to our previous study. To seek potential candidate target genes of calcium overload induced by scopoletin in , RNA-seq was utilized to detect changes in transcription levels. 24 and 48 h after treatment, 70 and 102 differentially expressed genes were obtained, respectively.

Association of maternal disease and medication use with the risk of congenital heart defects in offspring: a case-control study using logistic regression with a random-effects model.

Objective To examine the association between maternal diseases and congenital heart defects (CHDs) and to evaluate whether those associations vary with corresponding medication use. Methods A multi-hospital case-control study conducted from February 2010 to December 2014 analysed 916 controls and 1236 cases. Participating mothers were asked whether they suffered from influenza, common cold, herpes and threatened abortion or had used corresponding medication during the periconception period or the early pregnancy period.

Facile insertion of ethylene into a group 14 element-carbon bond: effects of the HOMO-LUMO energy gap on reactivity.

The diarylstannylenes, Sn(AriPr4)2 and Sn(AriPr6)2, (AriPr4 = C6H3-2,6-(C6H3-2,6-iPr2)2, AriPr6 = C6H3-2,6-(C6H2-2,4,6-iPr3)2), undergo a facile migratory insertion reaction with ethylene at 60 °C to afford the alkyl aryl stannylenes AriPr4SnCH2CH2AriPr4 and AriPr6SnCH2CH2AriPr6 which were characterized via1H, 13C and 119Sn NMR, UV-vis and IR spectroscopy, as well as by X-ray crystallography. Quantum mechanical calculations were performed, and two potential mechanisms were identified, with a migratory insertion reaction pathyway being energetically preferred.

Phenolic profile, free amino acids composition and antioxidant potential of dried longan fermented by lactic acid bacteria.

In this study, dried longan pulp (DLP) was subjected to fermentation using selected strains of lactic acid bacteria ( subsp. and ). We then studied changes in the free and bound phytochemical profile, antioxidant activity, free amino acid, and organic acid composition.

Increased Cthrc1 Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-β/Smad Signal Pathway and Modulating YAP Subcellular Location.

Keloid may induce severe impairment of life quality for the patients, although keloid is a cutaneous benign tumor. Collagen triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial injury. To address the role of Cthrc1 in keloid, the expression level of Cthrc1 was assessed in normal skin and keloid tissue, as well as in normal fibroblasts (NFs) and keloid fibroblasts (KFs) by using quantitative PCR, Western blotting and immunohistochemical analysis.