Publications by authors named "Ting Kai Chang"
Photoelectrochemical Enhancement of CuO by a CuTe Hole Transmission Interlayer.
ACS Appl Mater Interfaces
November 2022
Article Synopsis
- Cuprous oxide (CuO) films are created on fluorinated tin oxide (FTO) substrates with specific crystal orientations, achieving a transformation in morphology from pyramid to cuboidal shapes with higher current densities.
- The cuboidal crystallites, featuring (100) and (111) surfaces, show enhanced photoelectrochemical properties compared to the original pyramid shape.
- Introducing a copper(I) telluride (CuTe) layer boosts photocurrent density by 70% in certain conditions, primarily by improving the separation and flow of charge carriers in the CuO film.
Plants of the species Gomphocarpus physocarpus, commonly known as balloon plant or swan plant, exhibiting virus-like symptoms of mosaic, mottle and crinkling were observed and collected in the southwestern part of Taiwan in 2015. Electron microscopic examination showed the presence of virus-like flexuous-rod particles. Potyvirus pinwheel-shape and laminated inclusion bodies were observed in the preparations of ultrathin sections of diseased leaves.
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- A compact silicon polarization beam splitter (PBS) is created using an asymmetrical directional coupler with a wide and a narrow waveguide that are optimized for TE and TM polarizations.
- The design allows for near-perfect coupling of the TM mode while the TE mode experiences significant uncoupling, making the PBS efficient despite its short length of about 8.13 μm.
- The simulation results indicate that the PBS has a broad operational bandwidth of around 100 nm, a large extinction ratio greater than 10 dB, and low insertion loss under 0.61 dB, while also considering fabrication tolerances.
Article Synopsis
- The study presents wavelength-selective reflectors made from silicon microdisk resonators paired with compact Y-branch splitters, utilizing CMOS-photonics technology.
- A high quality factor (Q) of approximately 88,000 was achieved in a larger 2.5-μm-radius device, while a smaller 1.5-μm-radius device provided an ultra-wide free-spectral range (FSR) of over 71 nm but with a reduced Q of about 4000.
- The research explores the coupling between microdisks and waveguides and proposes a multichannel sensing system using multiple microdisk reflectors.
Article Synopsis
- The study proposes structural models for diterpene cyclases using various scientific techniques, despite the lack of existing structures for these enzymes.
- Bacterial diterpene cyclases are characterized by about 20 alpha-helices and conserved motifs similar to triterpene cyclases, suggesting a certain structural framework.
- Plant diterpene cyclases have a more complex structure with additional domains, indicating a potential evolutionary progression from simpler bacterial structures to more complex plant forms.
Considerable effort has focused on the development of selective protein farnesyl transferase (FTase) and protein geranylgeranyl transferase (GGTase) inhibitors as cancer chemotherapeutics. Here, we report a new strategy for anticancer therapeutic agents involving inhibition of farnesyl diphosphate synthase (FPPS) and geranylgeranyl diphosphate synthase (GGPPS), the two enzymes upstream of FTase and GGTase, by lipophilic bisphosphonates. Due to dual site targeting and decreased polarity, the compounds have activities far greater than do current bisphosphonate drugs in inhibiting tumor cell growth and invasiveness, both in vitro and in vivo.
View Article and Find Full Text PDFWe screened 26 bisphosphonates against a farnesyl diphosphate synthase from Plasmodium vivax, finding a poor correlation between enzyme and cell growth inhibition (R(2) = 0.06). To better predict cell activity data, we then used a combinatorial descriptor search in which pIC(50)(cell) = a pIC(50)(enzyme) + bB + cC + d, where B and C are descriptors (such as SlogP), and a-d are coefficients.
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