Strong upconverted circularly polarized emission from a chiral tetrahedral Yb/Eu cage.

Upconverted circularly polarized luminescence (UC-CPL) materials have attracted significant attention due to their potential in optical sensing and bioimaging. However, achieving UC-CPL in lanthanide supramolecular systems remains a challenge due to the extended distances between lanthanide ions. Here, enantiopure tetrahedral cages, (Yb/Eu)L(/-BINAPO), are assembled using achiral -symmetric ligands, Ln(III) ions and chiral ancillary ligands.

Role of Mitochondrial Dynamics in Skin Homeostasis: An Update.

Skin aging is the most prominent phenotype of host aging and is the consequence of a combination of genes and environment. Improving skin aging is essential for maintaining the healthy physiological function of the skin and the mental health of the human body. Mitochondria are vital organelles that play important roles in cellular mechanisms, including energy production and free radical balance.

Nomogram for predicting the postoperative outcomes in cervical spondylotic myelopathy based on apparent diffusion coefficient.

Purpose: To development a nomogram based on clinical features and apparent diffusion coefficient (ADC) of the cervical spinal cord in surgical prognosis in patients with cervical spondylotic myelopathy (CSM).

Methods: Patients with CSM who underwent decompression surgery between March and September 2023 were enrolled. Patients underwent conventional cervical spine MRI and sagittal position ZOOM-DWI before surgery.

An efficient circularly polarized luminescence probe base on anthryl-modified Eu(III)-helicates for the detection and imaging singlet oxygen in living cells.

Singlet oxygen (O) is the main active ingredient in photodynamic therapy (PDT). However, an excess O can cause unnecessary toxicity. Therefore, it is of great importance to develop reliable and sensitive methods or probes for detecting O in biological systems.

Deciphering the Pharmacological Mechanism of Compound Purpura Decoction in Treating Henoch-Schonlein Purpura by Network Pharmacology, Molecular Docking, and Experimental Validation.

Henoch-Schonlein purpura (HSP) is an immunoglobulin A (IgA)-mediated systemic vasculitis that frequently develops in children. Compound purpura decoction (CPD), a classical herbal combination, exerts favourable effects on the clinical symptoms and prognosis of HSP; however, the underlying molecular mechanism remains unclear. Firstly, HPLC analysis identified five bioactive components in CPD, including protocatechuic acid, chlorogenic acid, mangiferin, baicalin, and buddleoside, with concentrations of 0.

LeScore: a scoring function incorporating hydrogen bonding penalty for protein-ligand docking.

Context: Molecular docking is vital for structure-based virtual screening and heavily depends on accurate and robust scoring functions. Scoring functions often inadequately account for the breakage of solvent hydrogen bonds, hindering the accuracy of predicting binding energy. Here, we introduce LeScore, a novel scoring function that specifically incorporates the hydrogen bonding penalty (HBP) in an aqueous environment, aiming to penalize unfavorable polar interactions when hydrogen bonds with water are broken but the energy loss is not fully compensated by newly formed protein-ligand interactions.

Aspirin-responsive gene switch regulating therapeutic protein expression.

Current small-molecule-regulated synthetic gene switches face clinical limitations such as cytotoxicity, long-term side-effects and metabolic disturbances. Here, we describe an advanced synthetic platform inducible by risk-free input medication (ASPIRIN), which is activated by acetylsalicylic acid (ASA/aspirin), a multifunctional drug with pain-relieving, anti-inflammatory, and cardiovascular benefits. To construct ASPIRIN, we repurpose plant salicylic acid receptors NPR1 and NPR4.

Increase Docking Score Screening Power by Simple Fusion With CNNscore.

Scoring functions (SFs) of molecular docking is a vital component of structure-based virtual screening (SBVS). Traditional SFs yield their inherent shortage for idealized approximations and simplifications predicting the binding affinity. Complementarily, SFs based on deep learning (DL) have emerged as powerful tools for capturing intricate features within protein-ligand (PL) interactions.

CoS/MnS p-p heterojunction as a highly efficient electrocatalyst for water splitting and electrochemical oxidation of organic molecules.

In this work, CoS/MnS p-p heterojunction catalyst with hollow structure was successfully synthesized by one-step hydrothermal method. For oxygen evolution reaction (OER), urea oxidation reaction (UOR), lactate oxidation reaction (OER-LA) and glucose oxidation reaction (GOR), 1.59 V, 1.

Nitrogen‑phosphorus responses and Vis/NIR prediction in fresh tea leaves.

Nitrogen and phosphorus are essential nutrients for the growth and development of tea plants.However, the nitrogen content (NC) and phosphorus content (PC) in different parts of fresh tea has not been paid attention. In this study, the NC and PC responses different nitrogen stress were analyzed, and a quantitative regression model for predicting NC and PC was established by using Vis/NIR spectroscopy and a variety of intelligent algorithms.

Histone deacetylase in inflammatory bowel disease: novel insights.

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society and human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, is a key process in controlling DNA transcriptional activity.

The Scent of Lily Flowers: Advances in the Identification, Biosynthesis, and Regulation of Fragrance Components.

Lilies ( spp.) are renowned for their diverse and captivating floral scents, which are highly valued both commercially and ornamentally. This review provides a comprehensive overview of recent advancements in the identification, biosynthesis, and regulation of fragrance components in lily flowers.

Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases.

Background: Phospholipase C epsilon 1 (PLCε1) can hydrolyze phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate at the plasma membrane and perinuclear membrane in the cardiovascular system, producing lipid-derived second messengers. These messengers are considered prominent triggers for various signal transduction processes. Notably, diverse cardiac phenotypes have been observed in cardiac-specific and global Plce1 knockout mice under conditions of pathological stress.

Metabolic changes of thalamus assessed by H-MRS spectroscopy in patients of cervical spondylotic myelopathy following decompression surgery.

Objective: To assess the changes of thalamic metabolites before and after surgery in patients with Cervical Spondylotic Myelopathy (CSM) using Hydrogen Proton Magnetic Resonance Spectroscopy (H-MRS) and to investigate its association with improvement in neurological function.

Methods: Forty-eight CSM patients who underwent cervical decompression surgery from December 2022 to June 2023 were included, and 33 healthy volunteers were recruited. All subjects underwent bilateral thalamic H-MRS scans before the surgical procedure, and subsequently again 6 months later.

Novel inhibitors of the (VIBVN) NAT protein identified through pharmacophore modeling.

Arylamine N-acetyltransferases (NATs, E.C. 2.

Strong quantum nonlocality without entanglement in every -partition.

The orthogonal product set with quantum nonlocality can enhance the confidentiality of information without consuming entanglement resources. The confidentiality increases with the reinforcement of its nonlocality. However, the orthogonal product sets with the strongest nonlocality need an enormous number of quantum states.

The whole-genome dissection of root system architecture provides new insights for the genetic improvement of alfalfa ( L.).

Appropriate root system architecture (RSA) can improve alfalfa yield, yet its genetic basis remains largely unexplored. This study evaluated six RSA traits in 171 alfalfa genotypes grown under controlled greenhouse conditions. We also analyzed five yield-related traits in normal and drought stress environments and found a significant correlation (0.

Experimental Investigation of Cadmium Isotope Fractionation during Adsorption on Montmorillonite and Kaolinite.

Cadmium (Cd) isotopes have recently emerged as novel tracers of Cd sources and geochemical processes. Widespread clay minerals play a key role in Cd migration due to their strong adsorption capacity, but the mechanism of Cd isotope fractionation during adsorption onto clay minerals is poorly understood. Here, we experimentally investigated the adsorption mechanisms of Cd on montmorillonite (2:1) and kaolinite (1:1) by using extended X-ray absorption fine structure (EXAFS) spectroscopy.

A VZV-gE subunit vaccine decorated with mPLA elicits protective cellular immmune responses against varicella-zoster virus.

Herpes zoster is an acute infectious skin disease caused by the reactivation of latent varicella-zoster virus, vaccination, such as subunit vaccine with good safety, can effectively prevent shingles through increasing immunity of the body. However, protein antigens are prone to degradation and inactivation, which alone is generally not sufficient to induce potent immune effect. In this study, the liposomal vaccine platform modified with mPLA (TLR4 agonist) was developed to improve the immunogenicity of glycoprotein E (VZV-gE) derived from herpes zoster virus.

Solvent induced self-assembly of a dinuclear Eu(III) helicate and emergent strong CPL.

Herein, we report the influence of solvent on the self-assembly of a dinuclear helicate, (NMe)[Eu(LR)]. A multiple species mixture with the chemical composition of [Eu(LR)] present in CHCN can be transformed into a helicate upon increasing the content of CHCl, accompanied by a significant enhancement in circularly polarized luminescence activity.

Study on the Effect of Phillyrin on In Vivo and In Vitro.

As a zoonotic pathogen, serotype 2 (SS2) can cause severe diseases in both pigs and humans, and develop resistance to antibiotics. Plant natural compounds are regarded as promising alternatives to conventional antibiotics. Phillyrin is the major bioactive components of Chinese herbal medicine Forsythia suspensa.

Dim blue light at night worsens high-fat diet-induced kidney damage via increasing corticosterone levels and modulating the expression of circadian clock genes.

Obesity is a contributing factor that increases the likelihood of developing chronic kidney disease. In recent years, studies have found that light pollution worldwide promoted obesity, which was known to be a consequence of circadian rhythm disruption. Nevertheless, the impact of light pollution on kidney disease associated with obesity remains mostly unknown, and potential processes have been minimally investigated.

A Longitudinal Dynamic Change in LMR Can Be a Biomarker for Recurrence in Fusobacterium Nucleatum-Positive Colorectal Cancer Patients.

Purpose: This study assessed lymphocyte-to-monocyte ratio (LMR) changes to predict postoperative recurrence in Fusobacterium nucleatum-positive (Fn-positive) CRC patients.

Patients And Methods: Clinical information and paraffin tissue specimens were collected from a retrospective cohort of 332 patients. The abundance of Fn in tumor tissue was measured using a quantitative polymerase chain reaction.

Joint extraction of entity and relation based on fine-tuning BERT for long biomedical literatures.

Motivation: Joint extraction of entity and relation is an important research direction in Information Extraction. The number of scientific and technological biomedical literature is rapidly increasing, so automatically extracting entities and their relations from these literatures are key tasks to promote the progress of biomedical research.

Results: The joint extraction of entity and relation model achieves both intra-sentence extraction and cross-sentence extraction, alleviating the problem of long-distance information dependence in long literature.

A Meta-Analysis Assessing the Therapeutic Efficacy and Safety of Anlotinib in Combination with Chemotherapy for Small Cell Lung Cancer.

Introduction: This meta-analysis aimed to assess the effectiveness and safety of combining anlotinib with chemotherapy in treating patients with small cell lung cancer (SCLC).

Methods: We systematically searched a range of databases, including PubMed, Embase, Cochrane Library, and Web of Science, up to July 28, 2023, complemented by searches in Chinese databases such as CNKI, Wanfang, and VIP, through July 4, 2023. The outcomes analyzed were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), median PFS (mPFS), overall survival (OS), vascular endothelial growth factor (VEGF) levels, and the adverse events.