Publications by authors named "Ting Du"

Considering the increasing abundance of antibiotic-resistant bacteria, novel antimicrobial approaches need to be investigated. Photothermal therapy (PTT), an innovative noninvasive therapeutic technique, has demonstrated significant potential in addressing drug-resistant bacteria and bacterial biofilms. However, when used in isolation, PTT requires higher-temperature conditions to effectively eradicate bacteria, thereby potentially harming healthy tissues and inducing new inflammation.

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Cerebrospinal fluid (CSF) flow is crucial for clearing metabolic waste from the brain, a process whose dysregulation is linked to neurodegenerative diseases like Alzheimer's. Traditional approaches like particle tracking velocimetry (PTV) are limited by their reliance on single-plane two-dimensional measurements, which fail to capture the complex dynamics of CSF flow fully. To overcome these limitations, we employ artificial intelligence velocimetry (AIV) to reconstruct three-dimensional velocities, infer pressure and wall shear stress and quantify flow rates.

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Coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused secondary pandemic, which still poses a serious threat to physical health and economic development. Herein, the target-driven functionalized DNA hydrogel capillary sensor based on cascade signal amplification and carbon coated cobalt manganese modified by prussian blue and platinum nanoparticles (MnCo@C-Pt-PB NPs) has been successfully developed for dual-mode detection of SARS-CoV-2. The cascade signal amplification triggered by target RNA causes the permeability of the DNA hydrogel loaded in the capillary to be destroyed, thereby releasing the embedded MnCo@C-Pt-PB NPs as signal molecules into 3,3',5,5'-tetramethylbenzidine/hydrogen peroxide (TMB/HO) solution under the driving of capillarity.

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The acidophilic and heat-resistant traits of Alicyclobacillus acidoterrestris (A. acidoterrestris) present a formidable challenge to fruit juices production safety. To address the limitations of conventional thermal sterilization, a novel bacterial capture device MPDEL has been developed.

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One of the most promising approaches to effectively modulate the performance of immunochromatography (ICA) is the rational design of nanomaterials. It is anticipated to facilitate highly sensitive ICA analysis by introducing and controlling the internal defect structures of nanomaterials. Herein, we designed BiS@AuNPs with deep-level defect properties, revealing that these deep defects act as electron-hole nonradiative complex centers to promote phonon production, ultimately leading to photothermal analytical performance in ICA.

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Article Synopsis
  • * Probiotic lactobacillus strains, especially Lacticaseibacillus rhamnosus GG (LGG), show promise in enhancing immune responses to respiratory infections.
  • * In a study with mice, LGG reduced M. pneumoniae infection severity, improved immune response, and lessened lung inflammation, suggesting it may be an effective treatment strategy.
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Purpose: Heparan sulfate proteoglycans (HSPGs) are complex molecules found on the cell membrane and within the extracellular matrix, increasingly recognized for their role in tumor progression. This study aimed to investigate the involvement of Heparan sulfate proteoglycan 2 (HSPG2) in the progression of bladder cancer.

Methods: We identified HSPG2 as a promoter of bladder tumor progression using single-cell RNA sequencing and transcriptome analysis of sequencing data from seven patient samples obtained from the Gene Expression Omnibus (GEO) database (GSE135337).

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  • - A study was conducted to assess the impact of COVID-19 on newborn outcomes by comparing babies born to mothers infected and not infected with the virus during late pregnancy.
  • - Out of over 2000 pregnant women analyzed, those with COVID-19 had slightly higher rates of SARS-CoV-2 infection in newborns and longer hospital stays, but no significant differences in major neonatal complications were found.
  • - The conclusion suggests that COVID-19 infection during late pregnancy does not significantly affect newborn growth and development, which could help inform medical management and clinical practices.*
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Most COVID-19 patients have a positive prognosis, but patients with additional underlying diseases are more likely to have severe illness and increased fatality rates. Numerous studies indicate that cancer patients are more prone to contract SARS-CoV-2 and develop severe COVID-19 or even dying. In the recent transcriptome investigations, it is demonstrated that the fructose metabolism is altered in patients with SARS-CoV-2 infection.

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  • - The study develops a multifunctional nanosystem called HMAPH to tackle issues related to bacterial infections and wound healing by utilizing a combination of materials including methylene blue and gold particles to enhance the therapeutic effects of photodynamic therapy.
  • - HMAPH’s performance is analyzed through various scientific techniques, demonstrating its capability to release iron ions and generate reactive hydroxyl radicals, which are effective in killing bacteria when activated by light.
  • - The efficacy of HMAPH in promoting wound healing and reducing inflammation is validated through experiments on an infected mouse model, showing improved outcomes in tissue repair and infection control.
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The potential contamination, including microbial and mycotoxin infection, may escape from the naked eye, posing great threats to food products. Recently, photodynamic inactivation (PDI)-based technology particular has received particular attention because of their high safety. Herein, food-derived hesperetin (Hst) was innovatively introduced as an esculent photosensitizer, engineering with food-grade TiO nanoparticles (NPs) to form an organic-inorganic heterojunction structure.

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Biomacromolecule hydrogels possess excellent mechanical properties and biocompatibility, but their inability to combat bacteria restricts their application in the biomedical field. With the increasing requirements and demands for hydrogel dressings, wound dressings with antibacterial properties of biomacromolecule hydrogels reinforced by adding antibacterial agents have attracted much attention, and related reviews are emerging. In this paper, the advances of biomacromolecule antibacterial hydrogels (including chitosan, sodium alginate, Hyaluronic acid, cellulose and gelatin) were first overviewed, and the antibacterial agents incorporated into hydrogels were classified (including metals and their derivatives, carbon-based materials, and native compounds).

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The bactericidal properties of traditional food coatings mostly depend on the amount of fungicides present, which reduces the sustainability of food packaging. Herein, we proposed a magnetic field to precisely modulate the near-infrared (NIR) absorption activity to enhance antimicrobial coatings sustainability. Inspired by the typical grinding procedure, the assembly of CP/FeO@TA nanofiber hydrogel was proposed as the coating, applying mechanical force and encouraging the collision of effective molecules of puerarin (PUE), chitosan (CS), and FeO@TA NFs.

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Article Synopsis
  • Researchers used a special imaging technique called two-photon optical imaging to study how cervical lymphatic vessels (cLVs) drain cerebrospinal fluid (CSF) in live mice, revealing that contraction of the vessel walls is the main driving force of this flow.* -
  • They found that in older mice, the frequency of these contractions and the speed of fluid flow decreased, linked to lower levels of smooth muscle actin.* -
  • By applying prostaglandin F to aged mice, the researchers were able to enhance muscle contraction and improve CSF drainage, suggesting that boosting cLV function could help clear waste from the brain in aging individuals.*
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Background: Atopic dermatitis (AD) is a refractory disease that occurs in clinical practice. One of the most common inflammatory skin diseases, its occurrence and development are related to inflammation. Nevertheless, the precise nature of the relationship between circulating inflammatory proteins and AD remains uncertain.

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Enzymatic browning and microbial contamination of food threaten food sensory and safety. With the development of green and healthy concepts, there is a greater need for efficient, low-carbon antioxidant and antimicrobial strategies. In this study, we designed a nano-enzyme with antioxidant activities and biocompatibility.

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Article Synopsis
  • - The study explores the role of race dialogues, or discussions about race and racism among people of different racial backgrounds, in improving medical practices and patient experiences for racially minoritized groups.
  • - A scoping review analyzed 54 articles focusing on the necessary preparations, leadership qualities, and follow-up needed for effective race dialogues, highlighting the importance of trauma-informed practices and the need to center minoritized voices.
  • - Implementing race dialogues in medicine can foster a more inclusive environment, enhance colleague relationships, and ultimately lead to better care for patients from diverse racial identities.
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Background: Many phenolic C-glycosides possess nutritional benefits and pharmacological efficacies. However, the MS/MS fragmentation pattern of phenolic C-glycosides analysis is understudied. This paper aims to determine the MS/MS fragmentation patterns of phenolic C-glycosides.

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  • Nanoscale zerovalent iron created using borohydride (B-NZVI) has shown promise in cleaning up environmental contaminants, but the role of boron in boosting its reactivity has been underexplored.
  • A novel core-shell structure of B-NZVI is presented, which includes an Fe-B alloy shell that enhances hydrogen generation and provides electrons that aid in the removal of hexavalent chromium (Cr(VI)).
  • The B-NZVI exhibits significantly improved effectiveness—specifically, 6.5 times greater capacity and 6.9 times quicker reaction rates compared to traditional crystalline NZVI—demonstrating the critical contribution of alloyed boron in environmental remediation.
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To our knowledge, venetoclax is the first example of personalized medicine for multiple myeloma (MM), with meaningful clinical activity as a monotherapy and in combination in patients with myeloma harboring the t(11:14) translocation. However, despite the high response rates and prolonged progression-free survival, a significant proportion of patients eventually relapse. Here, we aim to study adaptive molecular responses after the acquisition of venetoclax resistance in sensitive t(11:14) MM cell models.

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Background: Palmoplantar warts (PWs) are a usual skin disease associated with human papillomavirus (HPV) that can affect patients' quality of life. The traditional Chinese medicine (TCM) Weiren Xiaoyou formula (WRXYF) is a relatively gentle and effective therapy that has achieved good therapeutic effects in clinical practice, but its mechanism has not yet been studied.

Methods: A meta-analysis was carried out to identify the potential advantages of topical TCM for PW treatment.

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() is a pathogenic fungus that can cause life-threatening meningitis, particularly in individuals with compromised immune systems. The current standard treatment involves the combination of amphotericin B and azole drugs, but this regimen often leads to inevitable toxicity in patients. Therefore, there is an urgent need to develop new antifungal drugs with improved safety profiles.

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DNA origami is capable of spatially organizing molecules into sophisticated geometric patterns with nanometric precision. Here we describe a reconfigurable, two-dimensional DNA origami with geometrically patterned CD95 ligands that regulates immune cell signalling to alleviate rheumatoid arthritis. In response to pH changes, the device reversibly transforms from a closed to an open configuration, displaying a hexagonal pattern of CD95 ligands with ~10 nm intermolecular spacing, precisely mirroring the spatial arrangement of CD95 receptor clusters on the surface of immune cells.

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CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases adenosine generation, overcomes immune suppression, and restores immune cell-mediated MM cell lysis. Based on these preclinical studies, a multi-center clinical trial of ORIC-533 has been initiated in patients with relapsed refractory MM (NCT05227144).

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