Dynamic niche technology based hybrid breeding optimization algorithm for multimodal feature selection.

As a primary approach to address feature selection problems, evolutionary algorithms have been widely proposed to deal with the problem. Most of these methods are designed to find a single feature subset. However, the optimal feature subset within a dataset is often not unique, indicating that feature selection exhibits multimodal characteristics.

Characterization and release of casein‑sodium alginate embedding phage edible film and the application in controlling of Salmonella contamination in food.

Salmonella remains a major foodborne pathogen responsible for food poisoning and poses a serious threat to public health. This study has developed an edible antimicrobial film using bacteriophage (phage) SaTp-04, specifically designed to capture and eliminate Salmonella in food. Optimal film conditions were achieved using casein (CA) and sodium alginate (SA) as the matrix, glycerol as the plasticizer, and phage protector.

Role of PLA2R domain antibodies and epitope spreading in risk stratification and prediction of proteinuria remission in primary membranous nephropathy.

The clinical significance of phospholipase A2 receptor (PLA2R) antigen domain-specific antibodies has not been determined. We investigated the role of serum PLA2R domain antibodies and epitope spreading in risk stratification and proteinuria remission in primary membranous nephropathy (PMN). Overall, 101 patients with PLA2R-associated MN diagnosed at the Wuxi People's Hospital between January 2019 and May 2021 were included and divided into low-to-medium risk (n = 12) and high-to-extremely-high risk (n = 89) groups.

Dietary herbs that interact with gut microbiota: roles as anti-stroke agents.

Unlabelled: Growing evidence suggests that dietary herbs can prevent stroke by regulating the composition and structure of gut microbiota. The components of dietary herbs can also be metabolized or converted into bioactive molecules for treating stroke by gut microbiota, and exert therapeutic effects by inhibiting inflammation, oxidative stress, apoptosis, and other processes caused by stroke. A deep understanding of the mechanism of gut microbiota-mediated dietary herbal intervention in stroke is of great significance for the treatment and drug screening of stroke diseases.

The Effect of HBV Therapy on Glycemic Control in HBV-Infected Patients With Diabetes: A 90-day Multicenter Study.

Patients with diabetes are at increased risk of HBV infection; however, the effects of HBV infection and anti-HBV therapy on the management of type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA) remain unclear. From 2016 to 2023, we recruited a multicenter cohort of 355 HBV-infected inpatients, including 136 with T1D, 140 with T2D, and 79 with LADA. The control group included 525 HBV-uninfected inpatients, comparing 171 with T1D, 204 with T2D and 150 with LADA.

Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma.

The two obstacles for treating glioma are the skull and the blood brain-barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage of the high penetrating ability of sonodynamic therapy (SDT), combined with a novel nanocomplex that can easily pass the BBB. Through ultrasonic polymerization, the amphiphilic peptides (CGRRGDS) were self-assembled as a spherical shell encapsulating a sonosensitizer Rose Bengal (RB) and a plant-derived compound, sulforaphane (SFN), to form the nanocomplex SFN@RB@SPM.

ALC-0315 Lipid-Based mRNA LNP Induces Stronger Cellular Immune Responses Postvaccination.

At the end of 2019, SARS-CoV-2 emerged and rapidly spread, having a profound negative impact on human health and socioeconomic conditions. In response to this unprecedented global health crisis, significant advancements were made in the mRNA vaccine technology. In this study, we have compared the difference between two SARS-CoV-2 receptor-binding domain (RBD) mRNA-Lipid nanoparticle (LNP) vaccines prepared from two different ionizable cationic lipids: ALC-0315 and MC3.

Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.

Background: Promoting muscle regeneration through stem cell therapy has potential risks. We investigated the effect of umbilical cord mesenchymal stem cells (UMSCs) Exosomes (Exo) Follistatin on muscle regeneration.

Methods: The Exo was derived from UMSCs cells and was utilized to affect the mice muscle injury model and C2C12 cells myotubes atrophy model.

Hybrid rice optimization algorithm inspired grey wolf optimizer for high-dimensional feature selection.

Feature selection (FS) is a significant dimensionality reduction technique, which can effectively remove redundant features. Metaheuristic algorithms have been widely employed in FS, and have obtained satisfactory performance, among them, grey wolf optimizer (GWO) has received widespread attention. However, the GWO and its variants suffer from limited adaptability, poor diversity, and low accuracy when faced with high-dimensional data.

Polyethyleneimine-modified Laminarin nanoparticles as a novel vaccine adjuvant for ovalbumin to enhance the immune responses.

Functional modification of drugs can significantly improve their efficacy and safety, thus enabling targeted therapy. Functional modifications based on polysaccharides can alter their molecular structure, and effectively enhance their functional properties and biological activities. Herein, we designed and synthesized cationic Laminarin (CLam) modified with polyethyleneimine (PEI) and explored its application as a vaccine adjuvant.

Shadow Effect-Triggered Photosensitive Gate of Organic Photoelectrochemical Transistor for Enhanced Biodetection.

The integration of a photosensitive gate into an organic electrochemical transistor has currently emerged as a promising route for biological sensing. However, the modification of the photosensitive gate always involves complex processes, and the degradation of sensitivity of the functional materials under illumination will significantly decrease the stability of the devices. Herein, we designed an organic photoelectrochemical transistor (OPECT) biosensor employing horseradish peroxidase (HRP)@glucose oxidase (GOx)/Pt/n-Si as the photosensitive gate based on the "shadow effect".

Isomerization-Controlled Aggregation in Photoactive Layer: An Additive Strategy for Organic Solar Cells with Over 19.5 % Efficiency.

Morphology control of the photoactive layer is crucial for achieving high-performance organic solar cells (OSCs), yet it remains a significant challenge in this field. One effective approach is the additive strategy, which fine-tunes the morphology of the photoactive layer. However, the underlying mechanisms governing the impact of different types of additives from liquid, solid, to volatile solid, on the bulk heterojunction morphology and device performance are not fully understood.

infection is associated with the risk and phenotypes of cholelithiasis: A multi-center study and meta-analysis.

Background: () is a prevalent pathogen associated with various diseases. Cholelithiasis is also a common condition. infection has been identified in the biliary system, suggesting its potential involvement in biliary diseases.

The Bro-Xre toxin-antitoxin modules in : inducing persister cells to escape tetracycline stress by disrupting metabolism.

Toxin-antitoxin (TA) modules are important mediators of persister cell formation in response to environmental stresses. However, the mechanisms through which persistence is controlled remain poorly understood. , a novel probiotic, can enter a persistent state upon exposure to tetracycline stress.

Lovastatin enhances humoral and cellular immune responses to H1N1 influenza vaccine.

The Swine Influenza Virus (SIV) is a major respiratory pathogen in swine, causing acute, febrile, and highly transmissible infections. This virus is widespread globally and poses significant risks to human health and social development. Traditional prevention strategies for SIV rely on the use of inactivated vaccines combined with Alum adjuvants.

Analysis of tracheal, bronchial, and lung cancer attributable to respiratory system-related risk factors in 204 countries and territories from 1990 to 2019.

Introduction: We analyzed trends in the tracheal, bronchial, and lung (TBL) cancer disease burdens attributable to respiratory system-related risk factors in 204 countries and territories from 1990 to 2019.

Material And Methods: Based on the results of the 2019 Global Burden of Disease study, we calculated and analyzed the estimated annual percentage changes (EAPCs) in the age-standardized disability-adjusted life year (DALY) rates and death rates of TBL cancer attributable to total and four individual risk factors globally, regionally, and nationally.

Results: From 1990 to 2019, the age-standardized DALY rate and death rate of TBL cancer only attributable to ambient particulate matter pollution increased globally, and in all Socio-Demographic Index (SDI) quintiles, except for high SDI quintiles.

Underwater image enhancement based on optimally weighted histogram framework and improved Fick's law algorithm.

The quality of underwater images is often affected by light scattering and attenuation, resulting in a loss of contrast and brightness. To address this issue, this paper proposes an underwater image enhancement method: improved Fick's law algorithm-based optimally weighted histogram framework (IFLAHF). The method incorporates the bi-histogram equalization-based three plateau limits (BHE3PL) technique to enhance image contrast and details while maintaining brightness.

Impact of Polymers on the Kinetics of the Solid-State Phase Transition of Piracetam Polymorphs.

Metastable polymorphs of active pharmaceutical ingredients can occasionally be used to enhance bioavailability or make processing more convenient. However, the thermodynamic instability of metastable polymorphs poses a severe threat to the quality and performance of the drug products. In this study, we used hot-stage microscopy and powder X-ray diffraction to quantitatively analyze the kinetics of the solid-solid phase transition of piracetam (PCM) polymorphs in the absence and presence of several polymeric excipients.

Electricity generation by B6-2 in microbial fuel cells using carboxylates and carbohydrate as substrates.

Microbial fuel cells (MFCs) employing B6-2 (ATCC BAA-2545) as an exoelectrogen have been developed to harness energy from various conventional substrates, such as acetate, lactate, glucose, and fructose. Owing to its metabolic versatility, B6-2 demonstrates adaptable growth rates on diverse, cost-effective carbon sources within MFCs, exhibiting distinct energy production characteristics. Notably, the anode chamber's pH rises with carboxylates' (acetate and lactate) consumption and decreases with carbohydrates' (glucose and fructose) utilization.

Role of the cathode chamber in microbial electrosynthesis: A comprehensive review of key factors.

The consumption of non-renewable fossil fuels has directly contributed to a dramatic rise in global carbon dioxide (CO) emissions, posing an ongoing threat to the ecological security of the Earth. Microbial electrosynthesis (MES) is an innovative energy regeneration strategy that offers a gentle and efficient approach to converting CO into high-value products. The cathode chamber is a vital component of an MES system and its internal factors play crucial roles in improving the performance of the MES system.

Histone Deacetylase 7-Derived 7-Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration.

Due to the complexity of wound healing, how to achieve successful healing is a significant clinical challenge. In this study, we found that the histone deacetylase-7-derived 7-amino acid peptide (7A, MHSPGAD), especially its phosphorylated version 7Ap (MH[pSer]PGAD), increased dermal fibroblast cell HDFα proliferation and migration via elevated delta-catenin (CTNND1) serine phosphorylation-mediated beta-catenin (CTNNB) nuclear translocation and subsequent upregulation of c-Myc and cyclin D1 expression. 7Ap physically interacted with platelet-derived growth factor receptor (PDGFR) and increased PDGFR interaction with cyclin-dependent kinase 6 (CDK6).

Effect of inoculation with different Eurotium cristatum strains on the microbial communities and volatile organic compounds of Fu brick tea.

Eurotium cristatum is the primary fungus in Fu brick tea (FBT) and plays a crucial role in its special flavor. This study investigated the effect of inoculation with different E. cristatum strains (i.

Cooperative metaheuristic algorithm for global optimization and engineering problems inspired by heterosis theory.

Swarm Intelligence-based metaheuristic algorithms are widely applied to global optimization and engineering design problems. However, these algorithms often suffer from two main drawbacks: susceptibility to the local optima in large search space and slow convergence rate. To address these issues, this paper develops a novel cooperative metaheuristic algorithm (CMA), which is inspired by heterosis theory.