NaHS immersion alleviates the stress effect of chromium(III) on alfalfa seeds by affecting active oxygen metabolism.

Objective: This study aimed to investigate the regulatory effects of exogenous hydrogen sulfide (HS) on seed germination, seedling growth, and reactive oxygen species (ROS) homeostasis in alfalfa under chromium (Cr) ion (III) stress.

Methods: The effects of 0-4 mM Cr(III) on the germination and seedling growth of alfalfa were first assessed. Subsequently, following seed NaHS immersion, the influence of HS on alfalfa seed germination and seedling growth under 2 mM Cr(III) stress was investigated, and the substance contents and enzyme activities associated with ROS metabolism were quantified.

Development of metabolome extraction strategy for metabolite profiling of skin tissue.

Introduction: Changes in skin phenotypic characteristics are based on skin tissue. The study of the metabolic changes in skin tissue can help understand the causes of skin diseases and identify effective therapeutic interventions.

Objectives: We aimed to establish and optimize a non-targeted skin metabolome extraction system for skin tissue metabolomics with high metabolite coverage, recovery, and reproducibility using gas chromatography/mass spectrometry.

Nomogram to predict the presence of PSMA-negative but FDG-positive lesion in castration-resistant prostate cancer: a multicenter cohort study.

Background: PSMA-negative but FDG-positive (PSMA-/FDG+) lesion in dual-tracer (Ga-PSMA and F-FDG) positron emission tomography/computed tomography (PET/CT) is associated with an unfavorable response to Lutetium-177 (Lu)-PSMA-617. This study sought to develop both radiomics and clinical models for the precise prediction of the presence of PSMA-/FDG+ lesions in patients with castration-resistant prostate cancer (CPRC).

Methods: A cohort of 298 patients who underwent dual-tracer PET/CT with a less than 5-day interval was included.

GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.

Skin has heterogenous identities on different body sites despite similar cellular compositions. There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear.

Efficient optical reservoir computing for parallel data processing.

We propose and experimentally demonstrate an optical reservoir computing system in free space, using second-harmonic generation for nonlinear kernel functions and a scattering medium to enhance reservoir nodes interconnection. We test it for one-step and multi-step predication of Mackey-Glass time series with different input-mapping methods on a spatial light modulator. For one-step prediction, we achieve 1.

Lu-PSMA-I&T Radioligand Therapy for Treating Metastatic Castration-Resistant Prostate Cancer: A Single-Centre Study in East Asians.

Purpose: There is increasing evidence for convincing efficacy and safety of Lu-labled prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT) for metastatic castration-resistant prostate cancer (mCRPC). However, data are not available regarding the feasibility of Lu-labled PSMA-targeted RLT in East Asians. The present study summarized the first experience with Lu-PSMA-I&T therapy for mCRPC in China.

Ga-DOTA-NT-20.3 Neurotensin Receptor 1 PET Imaging as a Surrogate for Neuroendocrine Differentiation of Prostate Cancer.

Prostate-specific membrane antigen (PSMA)-negative neuroendocrine prostate cancer (PCa) is a subtype of PCa likely to be lethal, with limited clinical diagnostic and therapeutic options. High expression of neurotensin receptor subtype 1 (NTR1) is associated with neuroendocrine differentiation of PCa, which makes NTR1 a potential target for neuroendocrine PCa. In this study, the NTR1-targeted tracer Ga-DOTA-NT-20.

Regulation effects of hydrogen sulfide on ascorbate-glutathione cycle in naked oat leaves under saline-alkali stress.

Saline-alkali stress is one of the common abiotic stresses for plants. Hydrogen sulfide (HS), as a gas signal, plays an important role in driving the responses of plants to saline-alkali stress. To explore the regulating effects of HS on the ascorbate (AsA)-glutathione (GSH) cycle in naked oat (Avena nude) under saline-alkali stress, we used sodium hydrogen sulfide (NaHS) as donor of exogenous HS and hydroxylamine (HA) as HS synthesis inhibitor to examine the effects of HS on plant growth, leaf reactive oxygen species, membrane lipid peroxidation, and antioxidants and key enzymes in the AsA-GSH cycle in "Dingyou 9" variety of naked oat under saline-alkali mixed stress.

Robust and efficient single-pixel image classification with nonlinear optics.

We present a hybrid image classifier by feature-sensitive image upconversion, single pixel photodetection, and deep learning, aiming at fast processing of high-resolution images. It uses partial Fourier transform to extract the images' signature features in both the original and Fourier domains, thereby significantly increasing the classification accuracy and robustness. Tested on the Modified National Institute of Standards and Technology handwritten digit images and verified by simulation, it boosts accuracy from 81.

Single-pixel pattern recognition with coherent nonlinear optics.

In this Letter, we propose and experimentally demonstrate a nonlinear-optics approach to pattern recognition with single-pixel imaging and a deep neural network. It employs mode-selective image up-conversion to project a raw image onto a set of coherent spatial modes, whereby its signature features are extracted optically in a nonlinear manner. With 40 projection modes, the classification accuracy reaches a high value of 99.

[Theranostics of osteosarcoma and lung metastasis with new integrin α β receptor targeted radiotracers].

Objective: To investigate the value of integrin α β targeted microPET/CT imaging with Ga-NODAGA-RGD as radiotracer for the detection of osteosarcoma and theranostics of osteosarcoma lung metastasis.

Methods: The Ga-NODAGA-RGD and Lu-NODAGA-RGD were prepared via one-step method and their stability and integrin α β binding specificity were investigated . Forty-one nude mice were injected with human MG63 osteosarcoma to established the animal model bearing subcutaneous osteosarcoma ( =21), osteosarcoma in tibia ( =5), and osteosarcoma pulmonary metastatic ( =15).

Decreased P-glycoprotein is associated with the inhibitory effects of static magnetic fields and cisplatin on K562 cells.

In this study, we explored the mechanism of the killing effects of a moderate-intensity static magnetic field (SMF) and cisplatin (DDP) on K562 cells. We analyzed the metabolic activity of cells, the extracellular DDP content, and P-glycoprotein (P-gp) expression after K562 cells were exposed continuously to a uniform 8.8 mT SMF for 8 h, with or without DDP.

Biologic effects of SMF and paclitaxel on K562 human leukemia cells.

In this study, we evaluated the ability of 8.8 mT static magnetic fields (SMF) to enhance the in vitro action of a chemotherapeutic agent, paclitaxel, against K562 human leukemia cells. We analyzed the cell proliferation, cell cycle distribution, DNA damage and alteration of cell surface and cell organelle ultrastructure after K562 cells were exposed to paclitaxel in the presence or absence of 8.