Publications by authors named "Ting Bao"

"Exercise is medicine" emphasizes personalized prescriptions for better efficacy. Current guidelines need more support for personalized prescriptions, posing scientific challenges. Facing those challenges, we gathered data from established guidelines, databases, and articles to develop the Exercise Medicine Ontology (EXMO), intending to offer comprehensive support for personalized exercise prescriptions.

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Nanoelectrodes, renowned for their small size, rapid mass transport, fast response, and high spatiotemporal resolution, have been recognized as a powerful tool in biosensing, especially for single-cell analysis. However, the nanoelectrode itself has no selectivity and cannot respond to nonelectroactive substances, limiting its wide application to some extent. Herein, we propose a simple and efficient electrochemical conjugation strategy to develop an electrochemical aptamer-coupled (E-AC) sensor for detecting adenosine triphosphate (ATP) in single living cells.

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Background And Aims: Guidelines for exercise recommendations are typically designed for the population as a whole and do not account for individual differences, making it challenging to provide personalized exercise training for individuals with complex conditions. To address this issue, this study aimed to develop PAHFKB (Physical Activity-Heart Failure Knowledge Base), a knowledge-based system for personalized exercise prescription (EP) for heart failure (HF), by mining, analyzing, and organizing existing literature and data on the relationship between physical activity (PA) and HF.

Methods: Firstly, 3186 citations on PAHF were gathered from PubMed.

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DNA walkers have emerged as a powerful tool in bioanalysis; however, many existing approaches are still restricted by low reaction kinetics and inaccurate single-mode detection. Herein, a fluorescence (FL) and electrochemical (EC) dual-mode biosensor was proposed based on a multispatially localized DNA walker (m-DNA walker) coupling covalent organic framework (COF) using the walking-recycling-conversion strategy. Specifically, the functionalized COF not only served as a three-dimensional nanocarrier but also acted as an effective quencher of the walking tracks.

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Article Synopsis
  • The study aimed to explore the use of lung ultrasound (LUS) to classify lung injury phenotypes, moving away from traditional CT scan methods, especially in critically ill patients.
  • A total of 821 patients underwent 1902 LUS examinations, leading to the development and validation of an algorithm that identified seven distinct LUS phenotypes through expert analysis and machine learning.
  • Key findings revealed that different lung conditions, such as acute respiratory distress syndrome (ARDS) and cardiogenic pulmonary edema, exhibited unique phenotypic traits, helping to enhance clinical diagnosis and treatment decisions.
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Background: Peripheral neuropathy can affect balance and increase fall risk. Tai Chi is known to activate neuromuscular systems and may help improve balance and postural control. We conducted a scoping review of clinical studies that evaluated the impact of Tai Chi on balance and related neurobiological outcomes among individuals with peripheral neuropathy.

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Background: Lung cancer screening (LCS) with low-dose computed tomography (LDCT) is an efficient method that can reduce lung cancer mortality in high-risk individuals. However, few studies have attempted to measure the preferences for LDCT LCS service delivery. This study aimed to generate quantitative information on the Chinese population's preferences for LDCT LCS service delivery.

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Background: Yoga interventions need fidelity monitoring to standardize the trial process and ensure adherence. We examined fidelity measures of current yoga trials and developed a fidelity assurance process in a phase III randomized clinical trial addressing chemotherapy-induced peripheral neuropathy among cancer survivors.

Methods: We qualitatively analyzed the fidelity monitoring components in published clinical trials on yoga therapy for chemotherapy-induced peripheral neuropathy through a literature search in PubMed from inception to February 2023.

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Realizing large materials models has emerged as a critical endeavor for materials research in the new era of artificial intelligence, but how to achieve this fantastic and challenging objective remains elusive. Here, we propose a feasible pathway to address this paramount pursuit by developing universal materials models of deep-learning density functional theory Hamiltonian (DeepH), enabling computational modeling of the complicated structure-property relationship of materials in general. By constructing a large materials database and substantially improving the DeepH method, we obtain a universal materials model of DeepH capable of handling diverse elemental compositions and material structures, achieving remarkable accuracy in predicting material properties.

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Molecular detection of nucleic acid plays an important role in early diagnosis and therapy of disease. Herein, a novel and enhanced electrochemical biosensor was exploited based on target-activated CRISPR/Cas12a system coupling with nanoparticle-labeled covalent organic frameworks (COFs) as signal reporters. Hollow spherical COFs (HCOFs) not only served as the nanocarriers of silver nanoparticles (AgNPs)-DNA conjugates for enhanced signal output but also acted as three-dimensional tracks of CRISPR/Cas12a system to improve the cleavage accessibility and efficiency.

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Background: Hot flashes are a common side effect of endocrine therapy (ET) that contribute to poor quality of life and decreased treatment adherence.

Methods: Patients with breast cancer wo were receiving ET and experiencing hot flashes were enrolled through three parallel, randomized trials conducted in the United States, China, and South Korea. Participants were randomized to either immediate acupuncture (IA) or delayed acupuncture control (DAC).

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Background: MicroRNA (miRNA) emerges as important cancer biomarker, accurate detection of miRNA plays an essential role in clinical sample analysis and disease diagnosis. However, it remains challenging to realize highly sensitive detection of low-abundance miRNA. Traditional detection methods including northern blot and real-time PCR have realized quantitative miRNA detection.

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Article Synopsis
  • The study investigates how exercise impacts chemotherapy-induced peripheral neuropathy (CIPN) symptoms in breast cancer survivors, finding that exercise may activate neuromuscular function and reduce these debilitating side effects.
  • Out of 5,444 breast cancer survivors surveyed, CIPN prevalence was 34%, with lower rates (28%) among those who exercised according to national guidelines compared to non-exercisers (38%).
  • The results indicate that increased exercise levels are associated with a decreased prevalence of CIPN symptoms, suggesting a dose-dependent benefit of physical activity post-chemotherapy.
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Cancer survivors including Asian American breast cancer survivors have reported their high needs for help during their survivorship process. With the COVID-19 pandemic, the necessity of technology-based programs to address their needs for help without face-to-face interactions has been highlighted. The purpose of this randomized intervention study was to determine the efficacy of a technology-based program in reducing various types of needs for help among this specific population.

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Article Synopsis
  • The study analyzed the results of Low-Dose Computed Tomography (LDCT) screenings in a population from West China Hospital to compare eligible and ineligible candidates based on lung cancer screening guidelines.
  • Findings showed that 64.13% of participants were ineligible for screening, with 39.04% of them testing positive, leading to a surgical lung biopsy rate of 4.17%.
  • Notably, ineligible candidates had a higher false-positive rate and a significant proportion of lung cancer cases, particularly lung adenocarcinoma, among current smokers, especially in males.
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Background: Epidemiological studies have shown that sarcopenia was associated with depression among older adults. However, most of these investigations used a cross-sectional design, limiting the ability to establish a causal relation, the present study examined whether sarcopenia was associated with incident depressive symptoms.

Methods: This is a prospective cohort study with participants from the Western China Health and Aging Trends (WCHAT) study.

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Objectives: Triglyceride glucose (TyG) represents a consistent surrogate biomarker and index of insulin resistance (IR), IR has also been linked to skeletal muscle mass loss (SMM-L). Here, we evaluated the association between SMM-L and the TyG index (TyGi).

Design: An analytical cross-sectional study.

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Prior studies have yielded mixed findings concerning the association between apolipoprotein E()- and serum lipids in patients with Alzheimer's disease (AD) and healthy individuals. Some studies suggested a relationship between and serum lipids in patients with AD and healthy individuals, whereas others proposed that the allele affects lipids only in patients with AD. Our study aimed to investigate whether alleles have a distinct impact on lipids in AD.

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Alpha-fetoprotein (AFP) is inextricably linked to various diseases, including liver cancer. Thus, detecting the content of AFP in biology has great significance in diagnosis, treatment, and intervention. Motivated by the urgent need for affordable and convenient electronic sensors in the analysis and detection of aqueous biological samples, we combined the solution-gated graphene transistor (SGGT) with the catalytic reaction of enzyme nanoprobes (HRP-AuNPs-Ab2) to accurately sense AFP.

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Article Synopsis
  • This study investigates the impact of COVID-19 on female patients with breast cancer, particularly focusing on underrepresented racial/ethnic populations from March 2020 to June 2021 in the US.
  • The analysis included 1,383 patients, revealing that older age and certain racial/ethnic groups (such as Black and Asian American/Pacific Islanders) showed higher odds of severe COVID-19 outcomes.
  • Key findings noted that factors like worse performance status, pre-existing health conditions, and active cancer significantly contributed to increased severity, while variables like Hispanic ethnicity and anti-cancer therapy type did not impact outcomes as much.
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A culturally tailored virtual program could meet the survivorship needs of Asian American women breast cancer survivors (AABC). This study aims to determine the efficacy of a culturally tailored virtual information and coaching/support program (TICAA) in improving AABC's survivorship experience. A randomized clinical trial (NCT02803593) was conducted from January 2017 to June 2020 among 199 AABC.

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Background: Plastic pollution is greatly serious in the ocean and soil. Microplastics (MPs) degraded from plastic has threatened animals and humans health. The accumulation of MPs in the tissues and blood in animals and humans has been found.

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Purpose: Chronic musculoskeletal pain is common and debilitating among breast cancer survivors. The PEACE trial demonstrated that electro-acupuncture (EA) and battle field auricular acupuncture (BFAA) both reduced pain more than usual care (UC) in cancer survivors. However, the comparative effectiveness between EA and BFAA among breast cancer survivors is unknown.

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