Blood protein assessment of leading incident diseases and mortality in the UK Biobank.

The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality in the UK Biobank (n = 47,600). We report 3,209 associations between 963 protein levels and 21 incident outcomes.

A novel method for quantitation of AAV genome integrity using duplex digital PCR.

Recombinant adeno-associated virus (rAAV) vectors have become a reliable strategy for delivering gene therapies. As rAAV capsid content is known to be heterogeneous, methods for rAAV characterization are critical for assessing the efficacy and safety of drug products. Multiplex digital PCR (dPCR) has emerged as a popular molecular approach for characterizing capsid content due to its high level of throughput, accuracy, and replicability.

Prospective cohort study of psoriatic arthritis risk in patients with psoriasis in a real-world psoriasis registry.

Background: The characteristics that predict the onset of psoriatic arthritis (PsA) among patients with psoriasis (PsO) may inform diagnosis and treatment.

Objective: To develop a model to predict the 2-year risk of developing PsA among patients with PsO.

Methods: This was a prospective cohort study of patients in the CorEvitas Psoriasis Registry without PsA at enrollment and with 24-month follow-up.

Cardiometabolic multimorbidity is common among patients with psoriasis and is associated with poorer outcomes compared to those without comorbidity.

Background: Associations between cardiometabolic multimorbidity and response to therapy in psoriasis are unknown.

Objective: Determine the associations of multimorbidity with response to biologic treatment in psoriasis patients.

Methods: CorEvitas Psoriasis Registry participants who initiated biologic therapy and had 6-month follow-up were stratified by 0, 1, 2+ comorbidities (diabetes, hypertension, hyperlipidemia).

Assessing the change in disease severity based on depressive symptoms in real-world psoriasis patients.

To evaluate whether the presence of a history of depression hinders psoriasis response to systemic therapies and to delineate baseline characteristics of patients whose depressive symptoms improved on systemic treatment. We studied patients within the Corrona Psoriasis Registry, a prospective, multicenter observational disease-based registry, that were enrolled through September 2018, comparing changes from enrollment to 12-month visit. There was a statistically significant improvement in all disease characteristics and most patient-reported outcomes in patients reporting a history of depression and in those that did not while there was no statistically significant difference in the degree of change comparing these two cohorts.

Comorbid obesity and history of diabetes are independently associated with poorer treatment response to biologics at 6 months: A prospective analysis in Corrona Psoriasis Registry.

Background: Psoriasis is associated with comorbid systemic metabolic disease.

Objective: To assess possible associations of comorbid obesity, history of diabetes, hypertension, and hyperlipidemia with response to biologic treatment at 6 months among patients in CorEvitas' Psoriasis Registry.

Methods: Participants included 2924 patients initiating biologic therapy (tumour necrosis factor inhibitors [TNFi], interleukin [IL]-17i, IL-12/23i, or IL-23i) with baseline and 6-month follow-up visits available.

Combining statistics from two national complex surveys to estimate injury rates per hour exposed and variance by activity in the USA.

Background: A common issue in descriptive injury epidemiology is that in order to calculate injury rates that account for the time spent in an activity, both injury cases and exposure time of specific activities need to be collected. In reality, few national surveys have this capacity. To address this issue, we combined statistics from two different national complex surveys as inputs for the numerator and denominator to estimate injury rate, accounting for the time spent in specific activities and included a procedure to estimate variance using the combined surveys.

Association Between Sedentary Work and BMI in a U.S. National Longitudinal Survey.

Introduction: Technological advancements have made life and work more sedentary, and long hours of sitting are known to be associated with many health concerns. Several studies have reported an association between prolonged sitting time at work and weight gain, but the results are inconsistent. This study examined the relationship between sitting time at work and BMI using data from a large prospective cohort of U.

Differences in time use and activity patterns when adding a second job: implications for health and safety in the United States.

Objectives: We compared work and lifestyle activities for workers who work in 1 job with those who work in multiple jobs during a 1-week period.

Methods: We used information from the 2003-2011 American Time Use Survey to classify workers into 6 work groups based on whether they were a single (SJH) or multiple (MJH) job holder and whether they worked their primary, other, multiple, or no job on the diary day.

Results: The MJHs often worked 2 part-time jobs (20%), long weekly hours (27% worked 60+ hours), and on weekends.

Work in multiple jobs and the risk of injury in the US working population.

Objectives: We compared the risk of injury for multiple job holders (MJHs) with that for single job holders (SJHs).

Methods: We used information from the National Health Interview Survey for the years 1997 through 2011 to estimate the rate of multiple job holding in the United States and compared characteristics and rates of self-reported injury (work and nonwork) for SJHs versus MJHs.

Results: Approximately 8.

Son Preference and Children's Housework: The Case of India.

We use a nationally representative survey of Indian households (NFHS-3) to conduct the first study that analyzes whether son preference is associated with girls bearing a larger burden of housework than boys. Housework is a non-negligible part of child labor in which around 60 % of children in our sample are engaged. The preference for male offspring is measured by a mother's ideal proportion of sons among her offspring.

Does obesity contribute to non-fatal occupational injury? Evidence from the National Longitudinal Survey of Youth.

Objectives: The relationship between obesity and occupational injuries remains unclear in the literature due to limitations in study design and sample composition. To better assess the contribution of obesity to occupational injury, we used data from a nationally representative cohort, the National Longitudinal Survey of Youth 1979 (NLSY79) in 1988-2000.

Methods: We hypothesized that obesity contributes to workplace injury and tested the hypothesis using logistic regression with generalized estimating equations (GEE) and random-effects logistic regression.