Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer.

Background: Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes in S1P metabolism were associated with clinical outcomes in patients with NSCLC. Nevertheless, the roles of mRNA expression of major enzymes (, and ) in S1P metabolism for predicting outcomes in NSCLC patients have not been determined.