Publications by authors named "Tina Xiang"
The urothelium of the bladder functions as a waterproof barrier between tissue and outflowing urine. Largely quiescent during homeostasis, this unique epithelium rapidly regenerates in response to bacterial or chemical injury. The specification of the proper cell types during development and injury repair is crucial for tissue function.
View Article and Find Full Text PDFPparg, a nuclear receptor, is downregulated in basal subtype bladder cancers that tend to be muscle invasive and amplified in luminal subtype bladder cancers that tend to be non-muscle invasive. Bladder cancers derive from the urothelium, one of the most quiescent epithelia in the body, which is composed of basal, intermediate, and superficial cells. We find that expression of an activated form of Pparg (VP16;Pparg) in basal progenitors induces formation of superficial cells in situ, that exit the cell cycle, and do not form tumors.
View Article and Find Full Text PDFArticle Synopsis
- The urothelium is a protective layer in the bladder that prevents infections, handles fluid exchange, and shields against toxins, and the nuclear receptor Pparg is linked to urothelial differentiation and bladder cancer.
- Research reveals that Pparg is essential for the health of urothelial cells, influencing mitochondrial growth, cell maturation, and inflammation response during urinary tract infections (UTIs).
- In Pparg mutants, the maturation of crucial urothelial barrier cells is impaired, leading to ongoing inflammation and abnormal cell differentiation, highlighting Pparg's role beyond fat and immune cell development.