Publications by authors named "Tina Tripp"
Invest New Drugs
October 2012
Article Synopsis
- Chronic inflammation is linked to 25% of all cancers, with prostaglandin E(2) (PGE(2)) playing a significant role in this process, particularly through the enzyme microsomal prostaglandin E(2) synthase 1 (mPGES-1).
- Researchers screened a chemical library and identified 13 potential small molecule inhibitors of mPGES-1, focusing on their ability to bind the enzyme and reduce PGE(2) production in cancer cell lines.
- One promising compound, PGE0001, showed effective binding, reduced PGE(2) release in cancer cells, and demonstrated significant anti-tumor activity in animal models by inhibiting the PGE(2) synthesis pathway
