Tumor necrosis factor-alpha (TNF-α) levels in aqueous humor of primary open angle glaucoma.

Purpose: Tumor necrosis factor alpha (TNF-α), a macrophage/monocyte derived pluripotent cytokine is associated with tissue ischemia, neuronal damage and remodeling. The physiological level of TNF-α in aqueous humor of normal and glaucomatous eyes is unknown. In this study, we evaluated the TNF-α levels in aqueous in patients with primary open angle glaucoma (POAG) and compared them to controls.

Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report.

Introduction: A case of severe acute bilateral angle closure glaucoma with complete visual loss after oral topiramate therapy.

Case Presentation: A 34 year-old woman developed bilateral severe visual loss 2 days after doubling the dosage of topiramate. Her best-corrected visual acuity (BCVA) was counting fingers in both eyes (OU).