Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis.

Objectives: Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during osteoclastogenesis, however, are largely unexplored and it is unknown whether and how these processes are involved in bone homeostasis.

Methods: We metabolically and transcriptionally profiled cells during osteoclast and osteoblast generation.

HepGentox: a novel promising HepG2 reportergene-assay for the detection of genotoxic substances in complex mixtures.

Background: In risk assessment, genotoxicity is a key factor to determine the safety for the consumer. Most genotoxicity assays were developed for the assessment of pure substances. However, in recent years more attention has been given to complex mixtures, where usually low amounts of a substance are present.