Publications by authors named "Tina N Woods"
Angiotensin II (Ang II) activates p38 mitogen-activated protein kinase (p38 MAPK) and increases reactive oxygen species (ROS), but the nature of the relationship in vivo is not fully understood. We assess the effect of SB239063AN, a highly selective, orally active, p38 MAPK inhibitor, on Ang II-dependent hypertension, target-organ damage and ROS production. Sprague-Dawley rats and MAPKAP kinase-2 knockout mice were infused with Ang II.
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- Urotensin-II (U-II) is a powerful vasoconstrictor that could contribute to high blood pressure, with its effects mediated by a specific receptor (UT) in mice.
- The study compared blood flow responses in wild-type mice with UT receptors and those lacking the receptor, finding no significant differences in general heart function between the two.
- It was confirmed that the UT receptor is crucial for U-II's vasoconstrictive effect, but U-II's overall impact on normal blood pressure regulation in mice seems minimal.