In Vivo Evaluation of Two Hemorrhagic Shock Resuscitation Controllers with Non-Invasive, Intermittent Sensors.

Hemorrhage is a leading cause of preventable death in military and civilian trauma medicine. Fluid resuscitation is the primary treatment option, which can be difficult to manage when multiple patients are involved. Traditional vital signs needed to drive resuscitation therapy being unavailable without invasive catheter placement is a challenge.

Poly (β-amino Ester) Nanoparticles Modified with a Rabies Virus-derived peptide for the Delivery of Across a 3D Model of the Blood Brain Barrier.

Gene editing has emerged as a therapeutic approach to manipulate the genome for killing cancer cells, protecting healthy tissues, and improving immune response to a tumor. The gene editing tool achaete-scute family bHLH transcription factor 1 CRISPR guide RNA () is known to restore neuronal lineage potential, promote terminal differentiation, and attenuate tumorigenicity in glioblastoma tumors. Here, we fabricated a polymeric nonviral carrier to encapsulate ASCL1-gRNA by electrostatic interactions and deliver it into glioblastoma cells across a 3D in vitro model of the blood-brain barrier (BBB).