Publications by authors named "Tina Gorsek Sparovec"
Article Synopsis
- Placenta-specific trophoblast cells and tumor cells share characteristics like tissue invasion and immune system evasion, which are crucial for their survival and function.
- Both cell types are influenced by their surrounding microenvironments, impacting their ability to invade, form new blood vessels (angiogenesis), and avoid detection by the immune system.
- Unlike tumor cells, trophoblast cells have more stringent regulatory mechanisms governing their metabolism, proliferation, migration, and invasiveness, leading to distinct differences in their cellular behavior.
Regeneration of the endometrial stromal compartment in premenopausal women is likely maintained by the perivascular endometrial mesenchymal stem/stromal cells (eMSC) expressing sushi domain containing 2 (SUSD2). The fate of SUSD2+ eMSC during pregnancy and their role in decidualization is not fully known. The aim of our study was to determine the effect of progesterone on the stemness of the SUSD2+ eMSC isolated from non-pregnant uterine samples.
View Article and Find Full Text PDF