Publications by authors named "Tina Ejlalmanesh"
Article Synopsis
- Diabetes significantly increases the risk of cardiovascular diseases, particularly among individuals with type 2 diabetes (T2D), where circulating monocytes play a crucial role in inflammation related to both diabetes and atherosclerosis.* -
- A study involving 672 T2D patients found a positive correlation between blood monocyte counts and coronary artery calcium scores, which are indicators of cardiovascular risk, revealing distinct monocyte subtypes associated with varying cardiovascular risk levels.* -
- The research indicates that analyzing monocyte frequency and profiles can serve as valuable predictors for cardiovascular events in T2D patients, highlighting potential mitochondrial dysfunction in these individuals' immune responses.*
Macrophages are innate immune cells with high phenotypic plasticity. Depending on the microenvironmental cues they receive, they polarize on a spectrum with extremes being pro- or anti-inflammatory. As well as responses to microenvironmental cues, cellular metabolism is increasingly recognized as a key factor influencing macrophage function.
View Article and Find Full Text PDFInflammation plays a key role in the development and progression of type-2 diabetes (T2D), a disease characterised by peripheral insulin resistance and systemic glucolipotoxicity. Visceral adipose tissue (AT) is the main source of inflammation early in the disease course. Macrophages are innate immune cells that populate all peripheral tissues, including AT.
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- - Aging is linked to fat tissue issues like inflammation and fibrosis, and HIV-infected individuals, particularly older ones, have a greater risk of trunk fat gain, indicating that the virus may affect fat tissue aging and function.
- - Research on SIV-infected macaques and human adipose stem cells showed that viral proteins Tat and Nef increased signs of fat tissue aging and dysfunction, including oxidative stress and mitochondrial problems.
- - The presence of HIV/SIV appears to accelerate fat tissue aging, potentially leading to altered fat cell functions and increased insulin resistance.
Monocytes and macrophages are cells of the innate immune system, existing in circulation and permeating every tissue of the human body. These cells represent the first responders to stress, and their inflammatory activation forms part of virtually every human disease. It is for these reasons that several approaches have been developed in order to phenotypically and functionally analyze these cells and their subpopulations.
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